129 research outputs found

    Energy Flow in Interjet Radiation

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    We study the distribution of transverse energy, Q_Omega, radiated into an arbitrary interjet angular region, Omega, in high-p_T two-jet events. Using an approximation that emphasizes radiation directly from the partons that undergo the hard scattering, we find a distribution that can be extrapolated smoothly to Q_Omega=Lambda_QCD, where it vanishes. This method, which we apply numerically in a valence quark approximation, provides a class of predictions on transverse energy radiated between jets, as a function of jet energy and rapidity, and of the choice of the region Omega in which the energy is measured. We discuss the relation of our approximation to the radiation from unobserved partons of intermediate energy, whose importance was identified by Dasgupta and Salam.Comment: 26 pages, 8 eps figures. Revised to include a discussion of non-global logarithm

    Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

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    The activating natural killer (NK) cell receptor Ly49H recognizes the mouse cytomegalovirus (MCMV) m157 glycoprotein expressed on the surface of infected cells and is required for protection against MCMV. Although Ly49H has previously been shown to signal via DAP12, we now show that Ly49H must also associate with and signal via DAP10 for optimal function. In the absence of DAP12, DAP10 enables Ly49H-mediated killing of m157-bearing target cells, proliferation in response to MCMV infection, and partial protection against MCMV. DAP10-deficient Ly49H+ NK cells, expressing only Ly49H–DAP12 receptor complexes, are partially impaired in their ability to proliferate during MCMV infection, display diminished ERK1/2 activation, produce less IFN-γ upon Ly49H engagement, and demonstrate reduced control of MCMV infection. Deletion of both DAP10 and DAP12 completely abrogates Ly49H surface expression and control of MCMV infection. Thus, optimal NK cell–mediated immunity to MCMV depends on Ly49H signaling through both DAP10 and DAP12
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