Fibrosarcoma Originating In The Mandible

Fibrosarcoma is a malignant mesenchymal neoplasm of fibroblasts that rarely affects the oral cavity and can cause local recurrences or metastasis. In this article we describe a case of primary fibrosarcoma in the mandible in a 16-year-old girl. Microscopically the tumor showed an intense proliferation of spindle-shaped cells, varying little in size and shape and arranged in parallel bands, partly crossing each other, the mitotic activity was increased and there was nuclear pleomorphism. Immunohistochemically the cells only showed immunoreactivity for vimentin and negativity for S-100 protein, CD 68, cytokeratin cocktail, HMB-45, CD34, pan actin HHF 35, desmin, smooth muscle actin and epithelial membrane antigen (EMA). Based on clinical, radiological, histological and immunohistochemical findings the final diagnosis was high-grade intra-osseous fibrosarcoma. The treatment choice was radical surgery with mandibular reconstruction. After one year and nine months of the treatment the patient displayed multiple metastases. Radiation therapy and chemotherapy were used as adjuvant treatment. Unfortunately, the girl died two years after the initial diagnosis. © Medicina Oral S. L. C.I.F. B 96689336.113191194Lo Muzio, L., Mignogna, M.D., Pannone, G., Staibano, S., Testa, N.F., A rare case of fibrosarcoma of the jaws in a 4-year-old male (1998) Oral Oncol, 34, pp. 383-386Richardson, J.F., Fine, M.A., Goldman, H.M., Fibrosarcoma of the mandible: A clinicopathologic controversy: Report of a case (1972) J Oral Surg, 30, pp. 664-668Mark, R.J., Sercarz, J.A., Tran, L., Selch, M., Calcaterra, T.C., Fibrosarcoma of the Head and Neck. The UCLA experience (1991) Arch Otolaryngol Head Neck Surg, 117, pp. 396-401McKenna, W.G., Barnes, M.M., Kinsella, T.J., Rosenberg, S.A., Lack, E.E., Glatstein, E., Combined modality treatment of adult soft tissue sarcomas of the head and neck (1987) Int J Radiat Oncol Biol Phys, 13, pp. 1127-1133Van Blarcom, C.W., Masson, J.K., Dahlin, D.C., Fibrosarcoma of the mandible. A clinicopathologic study (1971) Oral Surg Oral Med Oral Pathol, 32, pp. 428-439Sadoff, R.S., Rubin, M.M., Fibrosarcoma of the mandible: A case report (1990) J Am Dent Assoc, 121, pp. 247-248Handlers, J.P., Abrams, A.M., Melrose, R.J., Milder, J., Fibrosarcoma of the mandible presenting as a periodontal problem (1985) J Oral Pathol, 14, pp. 351-356Pereira, C.M., Jorge Junior, J., Di Hipólito, O., Kowalski, L.P., Lopes, M.A., Primary intraosseous fibrosarcoma of jaw (2005) Int J Oral Maxillofac Surg, 34, pp. 579-581Antonescu, C.R., Erlandson, R.A., Huvos, A.G., Primary fibrosarcoma and malignant fibrous histiocytoma of bone - A comparitive ultrastructural study: Ecidence of a spectrum of fibroblastic differentiation (2000) Ultrastruct Pathol, 24, pp. 83-91Mosqueda-Taylor, A., Meneses-García, A., Ruíz-Godoyrivera Lm Suárez-Roa, M.I., Luna-Ortiz, K., Malignant odontogenic tumors. A retrospective and collaborative study of seven cases (2003) Med Oral, 8, pp. 110-121Huguet, P., Castellvi, J., Avila, M., Alejo, M., Autonell, F., Basas, C., Ameloblastic fibrosarcoma: Report of a case. Immunohistochemical study and review of the literature (2001) Med Oral, 6, pp. 173-179Yamaguchi, S., Nagasawa, H., Suzuki, T., Fujii, E., Iwaki, H., Takagi, M., Sarcomas of the oral and maxillofacial region: A review of 32 cases in 25 years (2004) Clin Oral Invest, 8, pp. 52-55Lukinmaa, P.L., Hietanen, J., Swan, H., Ylipaavalniemi, P., Perkki, K., Maxillary fibrosarcoma with extracellular immuno-characterization (1988) Br J Oral Maxillofac Surg, 26, pp. 36-4

Nonlinear coupled Alfv\'{e}n and gravitational waves

In this paper we consider nonlinear interaction between gravitational and electromagnetic waves in a strongly magnetized plasma. More specifically, we investigate the propagation of gravitational waves with the direction of propagation perpendicular to a background magnetic field, and the coupling to compressional Alfv\'{e}n waves. The gravitational waves are considered in the high frequency limit and the plasma is modelled by a multifluid description. We make a self-consistent, weakly nonlinear analysis of the Einstein-Maxwell system and derive a wave equation for the coupled gravitational and electromagnetic wave modes. A WKB-approximation is then applied and as a result we obtain the nonlinear Schr\"{o}dinger equation for the slowly varying wave amplitudes. The analysis is extended to 3D wave pulses, and we discuss the applications to radiation generated from pulsar binary mergers. It turns out that the electromagnetic radiation from a binary merger should experience a focusing effect, that in principle could be detected.Comment: 20 pages, revtex4, accepted in PR