Process Control in IC Manufacturing with Thermal Waves

In today’s semiconductor market, manufacturers face a daunting challenge. Product concepts evolve rapidly in response to rapidly changing markets while design rules, i.e., device geometries, become increasingly smaller and wafers become larger. Devices must run faster, reliability must improve and the resultant increasing complexity in IC design and fabrication technology intensifies the need for tighter controls of process variables. To compete effectively in this market, manufacturers must improve both product development and product manufacturing processes

Response of Laser-Induced Thermal Lens Effect at Solid Surface

Recently Kuo et al. [1,2] and Satio et al.[3] presented the surface-thermal lens (STL) technique, this novel photothermal deformation technique has attracted great attention because it is a highly sensitive, noncontact and nondestructive measurement[4–6]. In this technique, a modulated pump beam is focused on the sample surface to produce the surface deformation and a cw probe beam is incident at the deformation region. Differing from the conventional photothermal deformation techniques, the spot size of the probe beam at the sample surface is much larger than the pump beam one. Then the probe beam reflected from the surface produces a diffraction pattern at the detection plane. More recently, STL technique has been successfully applied to study the temperature dependence of the thermal conductivity of semiconductor materials[5], weak absorption of optical thin films[6] and characterization of the solid materials[7,8]. However, the mechanism of STL phenomena has not been completely understood. Most theoretical models took no account of the influence of the air-thermal lens (ATL), although some experiment showed that the air significantly affected the detected diffraction pattern[2]. In addition, it is necessary to characterize frequency responses of signals because the response is used to determine the thermal property of the solid materials[5]

RNA expression of TLR10 in normal equine tissues

Background: Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. Results: This paper describes the genetic structure of the Equine TLR10 gene and its RNA expression in a range of horse tissues. It describes the phylogenetic analysis of the Equine TLR1,6,10,2 annotations in the horse genome, firmly identifying them in their corresponding gene clades compared to other species and firmly placing the horse gene with other TLR10 genes from odd-toed ungulates. Additional 3’ transcript extensions to that annotated for TLR10 in the horse genome have been identified by analysis of RNAseq data. RNA expression of the equine TLR10 gene was highest in peripheral blood mononucleocytes and lymphoid tissue (lymph nodes and spleen), however some expression was detected in all tissues tested (jejunum, caudal mesenteric lymph nodes, bronchial lymph node, spleen, lung, colon, kidney and liver). Additional data on RNAseq expression of all equine TLR genes (1–4 and 6–10) demonstrate higher expression of TLR4 than other equine TLRs in all tissues. Conclusion: The equine TLR10 gene displays significant homology to other mammalian TLR10 genes and could be reasonably assumed to have similar fuctions. Its RNA level expression is higher in resting state PBMCs in horses than in other tissues

Changing trends in mastitis

<p>Abstract</p> <p>The global dairy industry, the predominant pathogens causing mastitis, our understanding of mastitis pathogens and the host response to intramammary infection are changing rapidly. This paper aims to discuss changes in each of these aspects. Globalisation, energy demands, human population growth and climate change all affect the dairy industry. In many western countries, control programs for contagious mastitis have been in place for decades, resulting in a decrease in occurrence of <it>Streptococcus agalactiae </it>and <it>Staphylococcus aureus </it>mastitis and an increase in the relative impact of <it>Streptococcus uberis </it>and <it>Escherichia coli </it>mastitis. In some countries, <it>Klebsiella </it>spp. or <it>Streptococcus dysgalactiae </it>are appearing as important causes of mastitis. Differences between countries in legislation, veterinary and laboratory services and farmers' management practices affect the distribution and impact of mastitis pathogens. For pathogens that have traditionally been categorised as contagious, strain adaptation to human and bovine hosts has been recognised. For pathogens that are often categorised as environmental, strains causing transient and chronic infections are distinguished. The genetic basis underlying host adaptation and mechanisms of infection is being unravelled. Genomic information on pathogens and their hosts and improved knowledge of the host's innate and acquired immune responses to intramammary infections provide opportunities to expand our understanding of bovine mastitis. These developments will undoubtedly contribute to novel approaches to mastitis diagnostics and control.</p

LINGO-1 Exerts neuroprotection in a rat glaucoma model

Purpose: Axon regeneration in the central nervous system (CNS) is hindered by the presence of myelin inhibitory molecules. LINGO–1 is a new member of the myelin receptor complex besides NogoR1 and p75. This study was conducted to investigate the effect of LINGO–1 Fc fusion protein in the survival of retinal ganglion cells (RGCs) in a rat glaucoma model. Methods:Experimental glaucoma was induced in the right eye of each animal by elevating the intraocular pressure (IOP), and the left eye was used as control. Laser photocoagulation was applied twice to the episcleral and limbal veins at 7days interval. LINGO–1 Fc fusion protein was injected into the vitreous of the right eye after the first laser application. The loss of RGCs labeled by Fluoro–Gold was determined from flat–mounted retina 14 days later. Results:There was a significant loss of RGCs (13.2%) following the induction of elevated IOP in the PBS injection group. There was also a 10.6% RGCs loss in the human IgG injection group. A single intravitreal injection of LINGO–1 Fc fusion protein showed significant neuroprotective effect in enhancing the survival of RGCs (RGC death of –0.3%). Conclusions: These results provide evidence that LINGO–1 Fc fusion protein exerts neuroprotective activity to damaged RGCs in hypertensive eyes. It suggests that modulation of the interaction of myelin inhibitory proteins with their receptors has therapeutic application for CNS injury

Academic achievement in the Chinese context: The role of goals, strategies, and effort

Previous studies have suggested that Western constructs of academic motivation may operate in different ways in Asian contexts due to differences in the cultural environment. In the present study, the integrative effects of achievement goals, strategy orientations, and effort expenditure on achievement outcomes were examined among 1950 seventh-grade Chinese students in Hong Kong. Participants completed separate questionnaires for mathematics and English. Results for the two subjects were largely similar. There were significant positive relationships between mastery and performance goals, between cooperative and competitive orientations, as well as between understanding and memorizing strategies. Regression analyses further revealed that goals and strategies were highly predictive of effort expenditure, but only goals and effort significantly predicted achievement outcome, with strategies being barely significant. The need to further investigate how Chinese students reconcile the apparently antithetical orientations in learning as well as the effective strategies contributing to their learning is indicated. © 2008 International Union of Psychological Science.link_to_subscribed_fulltex

The design and performance of an ion trap storage--reflectron time-of-flight mass spectrometer

The design and performance of an ion trap storage--reflectron time-of-flight mass spectrometer (IT--RETOF MS) combination have been explored for detection of ions generated from both internal and external ionization sources. Ions were generated inside the trap using laser-induced resonance enhanced multiphoton ionization at 266 nm, while ions were generated external to the trap using eighter an atmospheric pressure or low pressure d.c. plasma souce or an electrospray ionization source. It is demonstrated herein that the ion trap provides an effective means of storing ions from 10 [mu]s up to 10 s prior to mass analysis via pulsed d.c. extraction into the RETOF MS device. In addition, it is shown that the storage capabilities of the device provide enhanced resolution and sensitivity as the storage time is increased. A resolution of nearly 2100 at m/z 93 is demonstrated using external injection from the atmospheric pressure d.c. plasma source when a storage time of 9 s is used before ejection. Further, a resolution of [approximate]3300 at m/z 1000 is demonstrated using external injection from an electrospray ionization source into the trap with a storage time of 931 ms. The IT--RETOF storage capabilities are shown to provide the potential for nearly 100% duty cycle in converting a continuous ion beam into a pulsed source of TOF. The detection limit of the device is demonstrated with liquid injection techniques for a typical sample and found to be in the low femtomole range. In addition, the r.f. voltage was shown to be an effective means of eliminating low mass background ions from the trap and, thus, from the TOF mass spectra obtained.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31765/1/0000706.pd