23,060 research outputs found
Structure and equation of state of interaction site models for disc-shaped lamellar colloids
We apply RISM (Reference Interaction Site Model) and PRISM (polymer-RISM)
theories to calculate the site-site pair structure and the osmotic equation of
state of suspensions of circular or hexagonal platelets (lamellar colloids)
over a range of ratios of the particle diameter over thickness. Despite the
neglect of edge effects, the simpler PRISM theory yields results in good
agreement with the more elaborate RISM calculations, provided the correct form
factor, characterizing the intramolecular structure of the platelets, is used.
The RISM equation of state is sensitive to the number of sites used to model
the platelets, but saturates when the hard spheres, associated with the
interaction sites, nearly touch; the limiting equation of state agrees
reasonably well with available simulation data for all densities up to the
isotropic-nematic transition. When properly scaled with the second virial
coefficient, the equations of state of platelets with different aspect ratios
nearly collapse on a single master curve.Comment: 10 Pages, 11 Figures, Typesetted using RevTeX
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Generation of Lamprey Monoclonal Antibodies (Lampribodies) Using the Phage Display System.
The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes. The diversity of the molecules is generated by stepwise genomic rearrangements of LRR cassettes dispersed throughout the VLRB locus. Previously, target-specific monovalent VLRB antibodies were isolated from sea lamprey larvae after immunization with model antigens. Further, the cloned VLR cDNAs from activated lamprey leukocytes were transfected into human cell lines or yeast to select best binders. Here, we expand on the overall utility of the VLRB technology by introducing it into a filamentous phage display system. We first tested the efficacy of isolating phage into which known VLRB molecules were cloned after a series of dilutions. These experiments showed that targeted VLRB clones could easily be recovered even after extensive dilutions (1 to 109). We further utilized the system to isolate target-specific "lampribodies" from phage display libraries from immunized animals and observed an amplification of binders with relative high affinities by competitive binding. The lampribodies can be individually purified and ostensibly utilized for applications for which conventional monoclonal antibodies are employed
Heat Capacity of Protein Folding
We construct a Hamiltonian for a single domain protein where the contact
enthalpy and the chain entropy decrease linearly with the number of native
contacts. The hydration effect upon protein unfolding is included by modeling
water as ideal dipoles that are ordered around the unfolded surfaces, where the
influence of these surfaces, covered with an ``ice-like'' shell of water, is
represented by an effective field that directs the water dipoles. An
intermolecular pair interaction between water molecules is also introduced. The
heat capacity of the model exhibits the common feature of small globular
proteins, two peaks corresponding to cold and warm unfolding, respectively. By
introducing vibrational modes, we obtain quantitatively good accordance with
experiments.Comment: 14 pages, LaTex, 4 figure
Data distributed, parallel algorithm for ray-traced volume rendering
Journal ArticleThis paper presents a divide-and-conquer ray-traced volume rendering algorithm and a parallel image compositing method, along with their implementation and performance on the Connection Machine CM-5, and networked workstations. This algorithm distributes both the data and the computations to individual processing units to achieve fast, high-quality rendering of high-resolution data. The volume data, once distributed, is left intact. The processing nodes perform local raytracing of their subvolume concurrently. No communication between processing units is needed during this locally ray-tracing process. A subimage is generated by each processing unit and the nal image is obtained by compositing subimages in the proper order, which can be determined a priori. Test results on both the CM-5 and a group of networked workstations demonstrate the practicality of our rendering algorithm and compositing method
Data distributed, parallel algorithm for ray-traced volume rendering
Journal ArticleThis paper presents a divide-and-conquer ray-traced volume rendering algorithm and a parallel image compositing method, along with their implementation and performance on the connection Machine CM-5, and networked workstations. This algorithm distributes both the data and the computations to individual processing units to achieve fast, high-quality rendering of high-resolution data. The volume data, once distributed, is left intact. The processing nodes perform local raytracing of their sub volume concurrently. No communication between processing units is needed during this locally ray-tracing process. A subimage is generated by each processing unit and the final image is obtained by compositing subimages in the proper order, which can be determined a priori. Test results on the CM-5 and a group of networked workstations demonstrate the practicality of our rendering algorithm and compositing method
Parallel volume rendering using binary-swap compositing
Journal ArticleExisting volume rendering methods, though capable of very effective visualizations, are computationally intensive and therefore fail to achieve interactive rendering rates for large data sets. Although computing technology continues to advance, computer processing power never seems to catch up to the increases in data size
Patients With Disabilities as Teachers (P-DAT): Do Participants Retain What Is Taught and is it Relevant to Practice?
Evidence for compact cooperatively rearranging regions in a supercooled liquid
We examine structural relaxation in a supercooled glass-forming liquid
simulated by NVE molecular dynamics. Time correlations of the total kinetic
energy fluctuations are used as a comprehensive measure of the system's
approach to the ergodic equilibrium. We find that, under cooling, the total
structural relaxation becomes delayed as compared with the decay of the
component of the intermediate scattering function corresponding to the main
peak of the structure factor. This observation can be explained by collective
movements of particles preserving many-body structural correlations within
compact 3D cooperatively rearranging regions.Comment: 8 pages, 4 figure
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