198 research outputs found
Micro Membrane Filters for Passive Plasma Extraction From Whole Human Blood Using Silicon Nitride-based Microfilters and Plama Collection Using Agarose Gels
AbstractThe novelty of this study resides in the fabrication of a passive, operating on capillary force, penetration-flow microfluidic device for plasma separation, based on both silicon nitride combination (SiN-SiO-SiN)-based microfilters and agarose gels, and its characterization for plasma separation from whole human blood. The fabrication processes are compatible with IC process protocols, with merits of mass productions and precise size control. The fabrication process for silicon nitride membrane was reported at Lab Chip [1], and quantification its applications to affinity-based protein separation on the silicon nitride was reported at MicroTAS’07 [2]. Our method differs from that of group Yobas [3] in the specific separation method and materials, and of group Pizziconi [4] in the geometry of the filter, and fluidic components with the structure
Analysis of Newtonian heating and higher-order chemical reaction on a Maxwell nanofluid in a rotating frame with gyrotactic microorganisms and variable heat source/sink
The goal of this study is to investigate the rotating Maxwell nanoliquid flow incorporating gyrotactic microbes with Newtonian heating and irregular heat source sink. The motion of the flow is induced due to linearly unidirectional elongated surface. The uniqueness of the flow is enhanced by the inclusion of additional phenomenon of higher order chemical reaction incorporated with Darcy Forchheimer flow, Fourier and Fick law. Numerical solution of the formulated problem is developed via bvp4c function in MATLAB. The influence of the embroiled parameters on the flow distribution is demonstrated through various graphs and tables. It is noticed that fluid velocity declines on incrementing the rotation parameter. An upsurge in thermal field is portrayed on augmenting the Newtonian heating. Comparative analysis of the results of the proposed model with previous published research is included which confirms the validity of the current model
4EHP and GIGYF1/2 mediate translation-coupled messenger RNA decay
Current models of mRNA turnover indicate that cytoplasmic degradation is coupled with translation. However, our understanding of the molecular events that coordinate ribosome transit with the mRNA decay machinery is still limited. Here, we show that 4EHP-GIGYF1/2 complexes trigger co-translational mRNA decay. Human cells lacking these proteins accumulate mRNAs with prominent ribosome pausing. They include, among others, transcripts encoding secretory and membrane-bound proteins or tubulin subunits. In addition, 4EHP-GIGYF1/2 complexes fail to reduce mRNA levels in the absence of ribosome stalling or upon disruption of their interaction with the cap structure, DDX6, and ZNF598. We further find that co-translational binding of GIGYF1/2 to the mRNA marks transcripts with perturbed elongation to decay. Our studies reveal how a repressor complex linked to neurological disorders minimizes the protein output of a subset of mRNAs
Synchronization and resonance in a driven system of coupled oscillators
We study the noise effects in a driven system of globally coupled
oscillators, with particular attention to the interplay between driving and
noise. The self-consistency equation for the order parameter, which measures
the collective synchronization of the system, is derived; it is found that the
total order parameter decreases monotonically with noise, indicating overall
suppression of synchronization. Still, for large coupling strengths, there
exists an optimal noise level at which the periodic (ac) component of the order
parameter reaches its maximum. The response of the phase velocity is also
examined and found to display resonance behavior.Comment: 17 pages, 3 figure
Phase synchronization and noise-induced resonance in systems of coupled oscillators
We study synchronization and noise-induced resonance phenomena in systems of
globally coupled oscillators, each possessing finite inertia. The behavior of
the order parameter, which measures collective synchronization of the system,
is investigated as the noise level and the coupling strength are varied, and
hysteretic behavior is manifested. The power spectrum of the phase velocity is
also examined and the quality factor as well as the response function is
obtained to reveal noise-induced resonance behavior.Comment: to be published in Phys. Rev.
SuperWIMP Dark Matter Signals from the Early Universe
Cold dark matter may be made of superweakly-interacting massive particles,
superWIMPs, that naturally inherit the desired relic density from late decays
of metastable WIMPs. Well-motivated examples are weak-scale gravitinos in
supergravity and Kaluza-Klein gravitons from extra dimensions. These particles
are impossible to detect in all dark matter experiments. We find, however, that
superWIMP dark matter may be discovered through cosmological signatures from
the early universe. In particular, superWIMP dark matter has observable
consequences for Big Bang nucleosynthesis and the cosmic microwave background
(CMB), and may explain the observed underabundance of 7Li without upsetting the
concordance between deuterium and CMB baryometers. We discuss implications for
future probes of CMB black body distortions and collider searches for new
particles. In the course of this study, we also present a model-independent
analysis of entropy production from late-decaying particles in light of WMAP
data.Comment: 19 pages, 5 figures, typos correcte
Complementarity of the CERN Large Hadron Collider and the International Linear Collider
The next-generation high-energy facilities, the CERN Large Hadron Collider
(LHC) and the prospective International Linear Collider (ILC), are
expected to unravel new structures of matter and forces from the electroweak
scale to the TeV scale. In this report we review the complementary role of LHC
and ILC in drawing a comprehensive and high-precision picture of the mechanism
breaking the electroweak symmetries and generating mass, and the unification of
forces in the frame of supersymmetry.Comment: 14 pages, 17 figures, to be published in "Supersymmetry on the Eve of
the LHC", a special volume of European Physical Journal C, Particles and
Fields (EPJC) in memory of Julius Wes
Continuous cropping of endangered therapeutic plants via electron beam soil treatment and neutron tomography
Various medicinal plants are threatened with extinction owing to their over exploitation and the prevalence of soil borne pathogens. In this study, soils infected with root rot pathogens, which prevent continuous cropping, were treated with an electron beam. The level of soil borne fungus was reduced to amp; 8804;0.01 by soil electron beam treatment without appreciable effects on the levels of antagonistic microorganism or on the physicochemical properties of the soil. The survival rate of 4 year old plant was higher in electron beam treated soil 81.0 than in fumigated 62.5 , virgin 78 , or untreatedreplanting soil 0 . Additionally, under various soils conditions, neutron tomography permitted the monitoring of plant health and the detection of root pathological changes over a period of 4 6 years by quantitatively measuring root water content in situ. These methods allow continual cropping on the same soil without pesticide treatment. This is a major step toward the environmentally friendly production of endangered therapeutic herb
The New Look pMSSM with Neutralino and Gravitino LSPs
The pMSSM provides a broad perspective on SUSY phenomenology. In this paper
we generate two new, very large, sets of pMSSM models with sparticle masses
extending up to 4 TeV, where the lightest supersymmetric particle (LSP) is
either a neutralino or gravitino. The existence of a gravitino LSP necessitates
a detailed study of its cosmological effects and we find that Big Bang
Nucleosynthesis places strong constraints on this scenario. Both sets are
subjected to a global set of theoretical, observational and experimental
constraints resulting in a sample of \sim 225k viable models for each LSP type.
The characteristics of these two model sets are briefly compared. We confront
the neutralino LSP model set with searches for SUSY at the 7 TeV LHC using both
the missing (MET) and non-missing ET ATLAS analyses. In the MET case, we employ
Monte Carlo estimates of the ratios of the SM backgrounds at 7 and 8 TeV to
rescale the 7 TeV data-driven ATLAS backgrounds to 8 TeV. This allows us to
determine the pMSSM parameter space coverage for this collision energy. We find
that an integrated luminosity of \sim 5-20 fb^{-1} at 8 TeV would yield a
substantial increase in this coverage compared to that at 7 TeV and can probe
roughly half of the model set. If the pMSSM is not discovered during the 8 TeV
run, then our model set will be essentially void of gluinos and lightest first
and second generation squarks that are \lesssim 700-800 GeV, which is much less
than the analogous mSUGRA bound. Finally, we demonstrate that non-MET SUSY
searches continue to play an important role in exploring the pMSSM parameter
space. These two pMSSM model sets can be used as the basis for investigations
for years to come.Comment: 54 pages, 22 figures; typos fixed, references adde
Quantum dots coordinated with conjugated organic ligands: new nanomaterials with novel photophysics
CdSe quantum dots functionalized with oligo-(phenylene vinylene) (OPV) ligands (CdSe-OPV nanostructures) represent a new class of composite nanomaterials with significantly modified photophysics relative to bulk blends or isolated components. Single-molecule spectroscopy on these species have revealed novel photophysics such as enhanced energy transfer, spectral stability, and strongly modified excited state lifetimes and blinking statistics. Here, we review the role of ligands in quantum dot applications and summarize some of our recent efforts probing energy and charge transfer in hybrid CdSe-OPV composite nanostructures
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