On D0-branes in Gepner models

We show why and when D0-branes at the Gepner point of Calabi-Yau manifolds given as Fermat hypersurfaces exist.Comment: 22 pages, substantial improvements in sections 2 and 3, references added, version to be publishe

Structure and structure relaxation

A discrete--dynamics model, which is specified solely in terms of the system's equilibrium structure, is defined for the density correlators of a simple fluid. This model yields results for the evolution of glassy dynamics which are identical with the ones obtained from the mode-coupling theory for ideal liquid--glass transitions. The decay of density fluctuations outside the transient regime is shown to be given by a superposition of Debye processes. The concept of structural relaxation is given a precise meaning. It is proven that the long-time part of the mode-coupling-theory solutions is structural relaxation, while the transient motion merely determines an overall time scale for the glassy dynamics

Orientifolds of Gepner Models

We systematically construct and study Type II Orientifolds based on Gepner models which have N=1 supersymmetry in 3+1 dimensions. We classify the parity symmetries and construct the crosscap states. We write down the conditions that a configuration of rational branes must satisfy for consistency (tadpole cancellation and rank constraints) and spacetime supersymmetry. For certain cases, including Type IIB orientifolds of the quintic and a two parameter model, one can find all solutions in this class. Depending on the parity, the number of vacua can be large, of the order of 10^{10}-10^{13}. For other models, it is hard to find all solutions but special solutions can be found -- some of them are chiral. We also make comparison with the large volume regime and obtain a perfect match. Through this study, we find a number of new features of Type II orientifolds, including the structure of moduli space and the change in the type of O-planes under navigation through non-geometric phases.Comment: 142 page

Fractional Branes in Non-compact Type IIA Orientifolds

We study fractional D-branes in the Type-IIA theory on a non-compact orientifold of the orbifold C^3/Z_3 in the boundary state formalism. We find that the fractional D0-branes of the orbifold theory become unstable due to the presence of a tachyon, while there is a stable D-instanton whose tachyon gets projected out. We propose that the D-instanton is obtained after tachyon condensation. We evidence this by calculating the Whitehead group of the Abelian category of objects corresponding to the boundary states as being isomorphic to Z_2.Comment: 29 pages, Latex2e minor corrections. references updated. Version accepted in JHE

The BPS Spectrum of N=2 SU(N) SYM and Parton Branes

We apply ideas that have appeared in the study of D-branes on Calabi-Yau compactifications to the derivation of the BPS spectrum of field theories. In particular, we identify an orbifold point whose fractional branes can be thought of as ``partons'' of the BPS spectrum of N=2 pure SU(N) SYM. We derive the BPS spectrum and lines of marginal stability branes near that orbifold, and compare our results with the spectrum of the field theories.Comment: 29 pages, 4 figures, includes package diagrams.tex by Paul Taylo

Linear Sigma Models for Open Strings

We formulate and study a class of massive N=2 supersymmetric gauge field theories coupled to boundary degrees of freedom on the strip. For some values of the parameters, the infrared limits of these theories can be interpreted as open string sigma models describing D-branes in large-radius Calabi-Yau compactifications. For other values of the parameters, these theories flow to CFTs describing branes in more exotic, non-geometric phases of the Calabi-Yau moduli space such as the Landau-Ginzburg orbifold phase. Some simple properties of the branes (like large radius monodromies and spectra of worldvolume excitations) can be computed in our model. We also provide simple worldsheet models of the transitions which occur at loci of marginal stability, and of Higgs-Coulomb transitions.Comment: 51 pages, 2 figures; very minor corrections, refs adde

Dibaryons from Exceptional Collections

We discuss aspects of the dictionary between brane configurations in del Pezzo geometries and dibaryons in the dual superconformal quiver gauge theories. The basis of fractional branes defining the quiver theory at the singularity has a K-theoretic dual exceptional collection of bundles which can be used to read off the spectrum of dibaryons in the weakly curved dual geometry. Our prescription identifies the R-charge R and all baryonic U(1) charges Q_I with divisors in the del Pezzo surface without any Weyl group ambiguity. As one application of the correspondence, we identify the cubic anomaly tr R Q_I Q_J as an intersection product for dibaryon charges in large-N superconformal gauge theories. Examples can be given for all del Pezzo surfaces using three- and four-block exceptional collections. Markov-type equations enforce consistency among anomaly equations for three-block collections.Comment: 47 pages, 11 figures, corrected ref

Fractional two-branes, toric orbifolds and the quantum McKay correspondence

We systematically study and obtain the large-volume analogues of fractional two-branes on resolutions of orbifolds C^3/Z_n. We study a generalisation of the McKay correspondence proposed in hep-th/0504164 called the quantum McKay correspondence by constructing duals to the fractional two-branes. Details are explicitly worked out for two examples -- the crepant resolutions of C^3/Z_3 and C^3/Z_5.Comment: 34 pages, 2 figures, LaTeX (JHEP3 style); (v2) typos corrected; (v3) sec 3 reorganise

A proteomics-based assessment of inflammation signatures in endotoxemia

We have previously shown that multimers of plasma pentraxin-3 (PTX3) were predictive of survival in patients with sepsis. To characterize the release kinetics and cellular source of plasma protein changes in sepsis, serial samples were obtained from healthy volunteers (n = 10; three time points) injected with low-dose endotoxin (lipopolysaccharide [LPS]) and analyzed using data-independent acquisition MS. The human plasma proteome response was compared with an LPS-induced endotoxemia model in mice. Proteomic analysis of human plasma revealed a rapid neutrophil degranulation signature, followed by a rise in acute phase proteins. Changes in circulating PTX3 correlated with increases in neutrophil-derived proteins following LPS injection. Time course analysis of the plasma proteome in mice showed a time-dependent increase in multimeric PTX3, alongside increases in neutrophil-derived myeloperoxidase (MPO) upon LPS treatment. The mechanisms of oxidation-induced multimerization of PTX3 were explored in two genetic mouse models: MPO global knock-out (KO) mice and LysM Cre Nox2 KO mice, in which NADPH oxidase 2 (Nox2) is only deficient in myeloid cells. Nox2 is the enzyme responsible for the oxidative burst in neutrophils. Increases in plasma multimeric PTX3 were not significantly different between wildtype and MPO or LysM Cre Nox2 KO mice. Thus, PTX3 may already be stored and released in a multimeric form. Through in vivo neutrophil depletion and multiplexed vascular proteomics, PTX3 multimer deposition within the aorta was confirmed to be neutrophil dependent. Proteomic analysis of aortas from LPS-injected mice returned PTX3 as the most upregulated protein, where multimeric PTX3 was deposited as early as 2 h post-LPS along with other neutrophil-derived proteins. In conclusion, the rise in multimeric PTX3 upon LPS injection correlates with neutrophil-related protein changes in plasma and aortas. MPO and myeloid Nox2 are not required for the multimerization of PTX3; instead, neutrophil extravasation is responsible for the LPS-induced deposition of multimeric PTX3 in the aorta

Open-closed string correspondence: D-brane decay in curved space

This paper analyzes the effect of curved closed string backgrounds on the stability of D-branes within boundary string field theory. We identify the non-local open string background that implements shifts in the closed string background and analyze the tachyonic sector off-shell. The renormalization group flow reveals some characteristic properties, which are expected for a curved background, like the absence of a stable space-filling brane. In 3-dimensions we describe tachyon condensation processes to lower-dimensional branes, including a curved 2-dimensional brane. We argue that this 2-brane is perturbatively stable. This is in agreement with the known maximally symmetric WZW-branes and provides further support to the bulk-boundary factorization approach to open-closed string correspondence.Comment: 23 pages, harvma