Electromotive forces and the Meissner effect puzzle

In a voltaic cell, positive (negative) ions flow from the low (high) potential electrode to the high (low) potential electrode, driven by an `electromotive force' which points in opposite direction and overcomes the electric force. Similarly in a superconductor charge flows in direction opposite to that dictated by the Faraday electric field as the magnetic field is expelled in the Meissner effect. The puzzle is the same in both cases: what drives electric charges against electromagnetic forces? I propose that the answer is also the same in both cases: kinetic energy lowering, or `quantum pressure'

Optical Sum Rule anomalies in the High-Tc Cuprates

We provide a brief summary of the observed sum rule anomalies in the high-T$_c$ cuprate materials. A recent issue has been the impact of a non-infinite frequency cutoff in the experiment. In the normal state, the observed anomalously high temperature dependence can be explained as a `cutoff effect'. The anomalous rise in the optical spectral weight below the superconducting transition, however, remains as a solid experimental observation, even with the use of a cutoff frequency.Comment: 4 pages, 2 figures, very brief review of optical sum rule anomal

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid‐beta peptide levels in vivo

J Lipid Res. 2007 Apr;48(4):914-23. Epub 2007 Jan 18. Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. Hirsch-Reinshagen V, Chan JY, Wilkinson A, Tanaka T, Fan J, Ou G, Maia LF, Singaraja RR, Hayden MR, Wellington CL. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. Abstract ABCA1-deficient mice have low levels of poorly lipidated apolipoprotein E (apoE) and exhibit increased amyloid load. To test whether excess ABCA1 protects from amyloid deposition, we crossed APP/PS1 mice to ABCA1 bacterial artificial chromosome (BAC) transgenic mice. Compared with wild-type animals, the ABCA1 BAC led to a 50% increase in cortical ABCA1 protein and a 15% increase in apoE abundance, demonstrating that this BAC supports modest ABCA1 overexpression in brain. However, this was observed only in animals that do not deposit amyloid. Comparison of ABCA1/APP/PS1 mice with APP/PS1 controls revealed no differences in levels of brain ABCA1 protein, amyloid, Abeta, or apoE, despite clear retention of ABCA1 overexpression in the livers of these animals. To further investigate ABCA1 expression in the amyloid-containing brain, we then compared ABCA1 mRNA and protein levels in young and aged cortex and cerebellum of APP/PS1 and ABCA1/APP/PS1 animals. Compared with APP/PS1 controls, aged ABCA1/APP/PS1 mice exhibited increased ABCA1 mRNA, but not protein, selectively in cortex. Additionally, ABCA1 mRNA levels were not increased before amyloid deposition but were induced only in the presence of extensive Abeta and amyloid levels. These data suggest that an induction of ABCA1 expression may be associated with late-stage Alzheimer's neuropathology. PMID: 17235115 [PubMed - indexed for MEDLINE

Locally continuously perfect groups of homeomorphisms

The notion of a locally continuously perfect group is introduced and studied. This notion generalizes locally smoothly perfect groups introduced by Haller and Teichmann. Next, we prove that the path connected identity component of the group of all homeomorphisms of a manifold is locally continuously perfect. The case of equivariant homeomorphism group and other examples are also considered.Comment: 14 page

Sum rules and energy scales in the high-temperature superconductor YBa2Cu3O6+x

The Ferrell-Glover-Tinkham (FGT) sum rule has been applied to the temperature dependence of the in-plane optical conductivity of optimally-doped YBa_2Cu_3O_{6.95} and underdoped YBa_2Cu_3O_{6.60}. Within the accuracy of the experiment, the sum rule is obeyed in both materials. However, the energy scale \omega_c required to recover the full strength of the superfluid \rho_s in the two materials is dramatically different; \omega_c \simeq 800 cm^{-1} in the optimally doped system (close to twice the maximum of the superconducting gap, 2\Delta_0), but \omega_c \gtrsim 5000 cm^{-1} in the underdoped system. In both materials, the normal-state scattering rate close to the critical temperature is small, \Gamma < 2\Delta_0, so that the materials are not in the dirty limit and the relevant energy scale for \rho_s in a BCS material should be twice the energy gap. The FGT sum rule in the optimally-doped material suggests that the majority of the spectral weight of the condensate comes from energies below 2\Delta_0, which is consistent with a BCS material in which the condensate originates from a Fermi liquid normal state. In the underdoped material the larger energy scale may be a result of the non-Fermi liquid nature of the normal state. The dramatically different energy scales suggest that the nature of the normal state creates specific conditions for observing the different aspects of what is presumably a central mechanism for superconductivity in these materials.Comment: RevTeX 4 file, 9 pages with 7 embedded eps figure

Surface Effects in Magnetic Microtraps

We have investigated Bose-Einstein condensates and ultra cold atoms in the vicinity of a surface of a magnetic microtrap. The atoms are prepared along copper conductors at distances to the surface between 300 um and 20 um. In this range, the lifetime decreases from 20 s to 0.7 s showing a linear dependence on the distance to the surface. The atoms manifest a weak thermal coupling to the surface, with measured heating rates remaining below 500 nK/s. In addition, we observe a periodic fragmentation of the condensate and thermal clouds when the surface is approached.Comment: 4 pages, 4 figures; v2: corrected references; v3: final versio

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada. Abstract ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be required to maintain normal apoE levels and lipidation in the central nervous system. In addition, ABCA1 has been reported to modulate beta-amyloid (Abeta) production in vitro. These observations raise the possibility that ABCA1 may play a role in the pathogenesis of Alzheimer disease. Here we report that the deficiency of ABCA1 does not affect soluble or guanidine-extractable Abeta levels in Tg-SwDI/B or amyloid precursor protein/presenilin 1 (APP/PS1) mice, but rather is associated with a dramatic reduction in soluble apoE levels in brain. Although this reduction in apoE was expected to reduce the amyloid burden in vivo, we observed that the parenchymal and vascular amyloid load was increased in Tg-SwDI/B animals and was not diminished in APP/PS1 mice. Furthermore, we observed an increase in the proportion of apoE retained in the insoluble fraction, particularly in the APP/PS1 model. These data suggested that ABCA1-mediated effects on apoE levels and lipidation influenced amyloidogenesis in vivo. PMID: 16207707 [PubMed - indexed for MEDLINE

DDW Order and its Role in the Phase Diagram of Extended Hubbard Models

We show in a mean-field calculation that phase diagrams remarkably similar to those recently proposed for the cuprates arise in simple microscopic models of interacting electrons near half-filling. The models are extended Hubbard models with nearest neighbor interaction and correlated hopping. The underdoped region of the phase diagram features $d_{{x^2}-{y^2}}$ density-wave (DDW) order. In a certain regime of temperature and doping, DDW order coexists with antiferromagnetic (AF) order. For larger doping, it coexists with $d_{{x^2}-{y^2}}$ superconductivity (DSC). While phase diagrams of this form are robust, they are not inevitable. For other reasonable values of the coupling constants, drastically different phase diagrams are obtained. We comment on implications for the cuprates.Comment: 7 pages, 3 figure

Gapless Assembly of Maize Chromosomes Using Long-Read Technologies

Creating gapless telomere-to-telomere assemblies of complex genomes is one of the ultimate challenges in genomics. We use two independent assemblies and an optical map-based merging pipeline to produce a maize genome (B73-Ab10) composed of 63 contigs and a contig N50 of 162 Mb. This genome includes gapless assemblies of chromosome 3 (236 Mb) and chromosome 9 (162 Mb), and 53 Mb of the Ab10 meiotic drive haplotype. The data also reveal the internal structure of seven centromeres and five heterochromatic knobs, showing that the major tandem repeat arrays (CentC, knob180, and TR-1) are discontinuous and frequently interspersed with retroelements