Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire

Chronic exposure to hypercortisolism has significant impact on patient's health and health-related quality of life (HRQoL), as demonstrated with generic questionnaires. We have developed a disease-generated questionnaire to evaluate HRQoL in patients with Cushing's syndrome (CS; CushingQoL). Objective: Validate the CushingQoL questionnaire in patients with CS in clinical practice conditions. Design: Observational, international, cross-sectional study. Methods: A total of 125 patients were recruited by 14 investigators from Spain, France, Germany. The Netherlands, and Italy over a 2-month period. Clinical and hormonal data were collected and correlated with results of the generic short form 3 6 (SF-36) questionnaire, a question on self-perceived general health status and the CushingQoL score. Results: A total of 107 patients were pituitary-dependent and 18 adrenal-dependent CS; 104 (83%) were females, mean age 45 years (range 20-73 years); 39 (31%) were currently hypercortisolemic; and 47 (38%) adrenal insufficient. In clinical practice, CushingQoL was feasible (117; 94% of patients fully responded to the questionnaire in a mean time of 4 min), reliable (Crohnbach's α=0.87), and valid (factorial analysis demonstrated unidimensionality and Rasch analysis lead to a final version with 12 items). A significant (P<0.001) correlation was observed between CushingQoL score and patients self-perceived general health status and dimensions of SF-36 (Pearson's correlation coefficient ≥0.597). Patients with current hypercortisolism scored worse (lower) than those without (44±22 vs 56±21, P=0.004). Linear regression analysis identified female gender and hypercortisolism as significant predictors for worse QoL. Conclusion: CushingQoL is useful to evaluate HRQoL in patients with CS and correlates with clinical parameters

Endogenous retroviral elements generate pathologic neutrophils in pulmonary arterial hypertension

Rationale: The role of neutrophils and their extracellular vesicles (EVs) in the pathogenesis of pulmonary arterial hypertension is unclear. Objectives: Relate functional abnormalities in pulmonary arterial hypertension neutrophils and their EVs to mechanisms uncovered by proteomic and transcriptomic profiling. Methods: Production of elastase, release of extracellular traps, adhesion and migration were assessed in neutrophils from pulmonary arterial hypertension patients and control subjects. Proteomic analyses were applied to explain functional perturbations, and transcriptomic data were used to find underlying mechanisms. CD66b-specific neutrophil EVs were isolated from plasma of patients with pulmonary arterial hypertension and we determined whether they produce pulmonary hypertension in mice. Measurements and Main Results: Neutrophils from pulmonary arterial hypertension patients produce and release increased neutrophil elastase, associated with enhanced extracellular traps. They exhibit reduced migration and increased adhesion attributed to elevated β1integrin and vinculin identified on proteomic analysis and previously linked to an antiviral response. This was substantiated by a transcriptomic interferon signature that we related to an increase in human endogenous retrovirus k envelope protein. Transfection of human endogenous retrovirus k envelope in a neutrophil cell line (HL-60) increases neutrophil elastase and interferon genes, whereas vinculin is increased by human endogenous retrovirus k dUTPase that is elevated in patient plasma. Neutrophil EVs from patient plasma contain increased neutrophil elastase and human endogenous retrovirus k envelope and induce pulmonary hypertension in mice, mitigated by elafin, an elastase inhibitor. Conclusions: Elevated human endogenous retroviral elements and elastase link a neutrophil innate immune response to pulmonary arterial hypertension

First measurement of antideuteron number fluctuations at energies available at the Large Hadron Collider

The first measurement of event-by-event antideuteron number fluctuations in high energy heavy-ion collisions is presented. The measurements are carried out at midrapidity (|\eta| |η|<0.8) as a function of collision centrality in Pb-Pb collisions at sNN=5.02  TeV using the ALICE detector. A significant negative correlation between the produced antiprotons and antideuterons is observed in all collision centralities. The results are compared with a state-of-the-art coalescence calculation. While it describes the ratio of higher order cumulants of the antideuteron multiplicity distribution, it fails to describe quantitatively the magnitude of the correlation between antiproton and antideuteron production. On the other hand, thermal-statistical model calculations describe all the measured observables within uncertainties only for correlation volumes that are different with respect to those describing proton yields and a similar measurement of net-proton number fluctuations.The first measurement of event-by-event antideuteron number fluctuations in high energy heavy-ion collisions is presented. The measurements are carried out at midrapidity (|\eta| < 0.8$) as a function of collision centrality in Pb$-$Pb collisions at$\sqrt{s_{\rm NN}} = 5.02$ TeV using the ALICE detector. A significant negative correlation between the produced antiprotons and antideuterons is observed in all collision centralities. The results are compared with a state-of-the-art coalescence calculation. While it describes the ratio of higher order cumulants of the antideuteron multiplicity distribution, it fails to describe quantitatively the magnitude of the correlation between antiproton and antideuteron production. On the other hand, thermal-statistical model calculations describe all the measured observables within uncertainties only for correlation volumes that are different with respect to those describing proton yields and a similar measurement of net-proton number fluctuations

Two-particle transverse momentum correlations in pp and p-Pb collisions at LHC energies

Two-particle transverse momentum differential correlators, recently measured in Pb-Pb collisions at LHC energies, provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb--Pb collisions. The longitudinal long-range correlations and the large azimuthal anisotropy measured at low transverse momenta in small collision systems, namely pp and p-Pb, at LHC energies resemble manifestations of collective behaviour. This suggests that locally equilibrated matter may be produced in these small collision systems, similar to what is observed in Pb-Pb collisions. In this work, the same two-particle transverse momentum differential correlators are exploited in pp and p-Pb collisions at $\sqrt{s} = 7$ TeV and $\sqrt{s_{\rm NN}} = 5.02$ TeV, respectively, to seek evidence for viscous effects. Specifically, the strength and shape of the correlators are studied as a function of the produced particle multiplicity to identify evidence for longitudinal broadening that might reveal the presence of viscous effects in these smaller systems. The measured correlators and their evolution from pp and p-Pb to Pb-Pb collisions are additionally compared to predictions from Monte Carlo event generators, and the potential presence of viscous effects is discussed.Two-particle transverse momentum differential correlators, recently measured in Pb--Pb collisions at energies available at the CERN Large Hadron Collider (LHC), provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb-Pb collisions. The longitudinal long-range correlations and the large azimuthal anisotropy measured at low transverse momenta in small collision systems, namely pp and p-Pb, at LHC energies resemble manifestations of collective behaviour. This suggests that locally equilibrated matter may be produced in these small collision systems, similar to what is observed in Pb-Pb collisions. In this work, the same two-particle transverse momentum differential correlators are exploited in pp and p-Pb collisions at $\sqrt{s} = 7$ TeV and $\sqrt{s_{\rm NN}} = 5.02$ TeV, respectively, to seek evidence for viscous effects. Specifically, the strength and shape of the correlators are studied as a function of the produced particle multiplicity to identify evidence for longitudinal broadening that might reveal the presence of viscous effects in these smaller systems. The measured correlators and their evolution from pp and p--Pb to Pb--Pb collisions are additionally compared to predictions from Monte Carlo event generators, and the potential presence of viscous effects is discussed.Two-particle transverse momentum differential correlators, recently measured in Pb-Pb collisions at energies available at the CERN Large Hadron Collider (LHC), provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb-Pb collisions. The longitudinal long-range correlations and the large azimuthal anisotropy measured at low transverse momenta in small collision systems, namely pp and p-Pb, at LHC energies resemble manifestations of collective behavior. This suggests that locally equilibrated matter may be produced in these small collision systems, similar to what is observed in Pb-Pb collisions. In this work, the same two-particle transverse momentum differential correlators are exploited in pp and p-Pb collisions at s=7TeV and sNN=5.02TeV, respectively, to seek evidence for viscous effects. Specifically, the strength and shape of the correlators are studied as a function of the produced particle multiplicity to identify evidence for longitudinal broadening that might reveal the presence of viscous effects in these smaller systems. The measured correlators and their evolution from pp and p-Pb to Pb-Pb collisions are additionally compared to predictions from Monte Carlo event generators, and the potential presence of viscous effects is discussed

First measurement of Λc+\Lambda_\mathrm{c}^{+} production down to pT=0p_\mathrm{T} = 0 in pp and p-Pb collisions at sNN=5.02\sqrt{s_\mathrm{NN}} = 5.02 TeV

The production of prompt ${\mathrm {\Lambda_{c}^{+}}}$ baryons has been measured at midrapidity in the transverse momentum interval 0 Λc+ baryons has been measured at midrapidity in the transverse momentum interval 0<pT<1 GeV/c for the first time, in pp and p–Pb collisions at a center-of-mass energy per nucleon-nucleon collision sNN=5.02TeV. The measurement was performed in the decay channel Λc+→pKS0 by applying new decay reconstruction techniques using a Kalman-Filter vertexing algorithm and adopting a machine-learning approach for the candidate selection. The pT-integrated Λc+ production cross sections in both collision systems were determined and used along with the measured yields in Pb–Pb collisions to compute the pT-integrated nuclear modification factors RpPb and RAA of Λc+ baryons, which are compared to model calculations that consider nuclear modification of the parton distribution functions. The Λc+/D0 baryon-to-meson yield ratio is reported for pp and p–Pb collisions. Comparisons with models that include modified hadronization processes are presented, and the implications of the results on the understanding of charm hadronization in hadronic collisions are discussed. A significant (3.7σ) modification of the mean transverse momentum of Λc+ baryons is seen in p–Pb collisions with respect to pp collisions, while the pT-integrated Λc+/D0 yield ratio was found to be consistent between the two collision systems within the uncertainties.The production of prompt \mathrm {\Lambda_{c}^{+}}$baryons has been measured at midrapidity in the transverse momentum interval$0<p_{\rm T}<1$GeV/$c$for the first time, in pp and p-Pb collisions at a centre-of-mass energy per nucleon-nucleon collision$\sqrt{s_\mathrm{NN}} = 5.02$TeV. The measurement was performed in the decay channel${\rm \Lambda_{c}^{+}\to p K^{0}_{S}}$by applying new decay reconstruction techniques using a Kalman-Filter vertexing algorithm and adopting a machine-learning approach for the candidate selection. The$p_{\rm T}$-integrated$\mathrm {\Lambda_{c}^{+}}$production cross sections in both collision systems were determined and used along with the measured yields in Pb-Pb collisions to compute the$p_{\rm T}$-integrated nuclear modification factors$R_{\rm pPb}$and$R_\mathrm{AA}$of$\mathrm{\Lambda_{c}^{+}}$baryons, which are compared to model calculations that consider nuclear modification of the parton distribution functions. The$\mathrm{\Lambda_{c}^{+}/D^0}$baryon-to-meson yield ratio is reported for pp and p-Pb collisions. Comparisons with models that include modified hadronisation processes are presented, and the implications of the results on the understanding of charm hadronisation in hadronic collisions are discussed. A significant ($3.7\sigma$) modification of the mean transverse momentum of$\mathrm {\Lambda_{c}^{+}}$baryons is seen in p-Pb collisions with respect to pp collisions, while the$p_{\rm T}$-integrated$\mathrm{\Lambda_{c}^{+}/D^0}$ yield ratio was found to be consistent between the two collision systems within the uncertainties

Measurements of the groomed jet radius and momentum splitting fraction with the soft drop and dynamical grooming algorithms in pp collisions at s \sqrt{s} = 5.02 TeV

This article presents measurements of the groomed jet radius and momentum splitting fraction in pp collisions at $\sqrt{s}=5.02$ TeV with the ALICE detector at the Large Hadron Collider. Inclusive charged-particle jets are reconstructed at midrapidity using the anti-$k_{\rm{T}}$ algorithm for transverse momentum $60< p_{\mathrm{T}}^{\rm{ch\; jet}}<80$ GeV/$c$. We report results using two different grooming algorithms: soft drop and, for the first time, dynamical grooming. For each grooming algorithm, a variety of grooming settings are used in order to explore the impact of collinear radiation on these jet substructure observables. These results are compared to perturbative calculations that include resummation of large logarithms at all orders in the strong coupling constant. We find good agreement of the theoretical predictions with the data for all grooming settings considered.This article presents measurements of the groomed jet radius and momentum splitting fraction in pp collisions at $\sqrt{s}$ = 5.02 TeV with the ALICE detector at the Large Hadron Collider. Inclusive charged-particle jets are reconstructed at midrapidity using the anti-k$_{T}$ algorithm for transverse momentum $60<{p}_{\textrm{T}}^{\textrm{ch}\;\textrm{jet}}<80$ GeV/c. We report results using two different grooming algorithms: soft drop and, for the first time, dynamical grooming. For each grooming algorithm, a variety of grooming settings are used in order to explore the impact of collinear radiation on these jet substructure observables. These results are compared to perturbative calculations that include resummation of large logarithms at all orders in the strong coupling constant. We find good agreement of the theoretical predictions with the data for all grooming settings considered.[graphic not available: see fulltext]This article presents measurements of the groomed jet radius and momentum splitting fraction in pp collisions at $\sqrt{s}=5.02$ TeV with the ALICE detector at the Large Hadron Collider. Inclusive charged-particle jets are reconstructed at midrapidity using the anti-$k_{\rm{T}}$ algorithm for transverse momentum $60< p_{\mathrm{T}}^{\rm{ch\; jet}}<80$ GeV/$c$. We report results using two different grooming algorithms: soft drop and, for the first time, dynamical grooming. For each grooming algorithm, a variety of grooming settings are used in order to explore the impact of collinear radiation on these jet substructure observables. These results are compared to perturbative calculations that include resummation of large logarithms at all orders in the strong coupling constant. We find good agreement of the theoretical predictions with the data for all grooming settings considered

Measurement of the angle between jet axes in pp collisions at s \sqrt{s} = 5.02 TeV

This article reports measurements of the angle between differently defined jet axes in pp collisions at $\sqrt{s} = 5.02$ TeV carried out by the ALICE Collaboration. Charged particles at midrapidity are clustered into jets with resolution parameters $R=0.2$ and 0.4. The jet axis, before and after Soft Drop grooming, is compared to the jet axis from the Winner-Takes-All (WTA) recombination scheme. The angle between these axes, $\Delta R_{\mathrm{axis}}$, probes a wide phase space of the jet formation and evolution, ranging from the initial high-momentum-transfer scattering to the hadronization process. The $\Delta R_{\mathrm{axis}}$ observable is presented for $20 < {p_{\mathrm{T}}^{\mathrm{ch\; jet}}}< 100$ GeV/$c$, and compared to predictions from the PYTHIA 8 and Herwig 7 event generators. The distributions can also be calculated analytically with a leading hadronization correction related to the non-perturbative component of the Collins$-$Soper$-$Sterman (CSS) evolution kernel. Comparisons to analytical predictions at next-to-leading-logarithmic accuracy with leading hadronization correction implemented from experimental extractions of the CSS kernel in Drell$-$Yan measurements are presented. The analytical predictions describe the measured data within 20% in the perturbative regime, with surprising agreement in the non-perturbative regime as well. These results are compatible with the universality of the CSS kernel in the context of jet substructure.This article reports measurements of the angle between differently defined jet axes in pp collisions at $\sqrt{s}$ = 5.02 TeV carried out by the ALICE Collaboration. Charged particles at midrapidity are clustered into jets with resolution parameters R = 0.2 and 0.4. The jet axis, before and after Soft Drop grooming, is compared to the jet axis from the Winner-Takes-All (WTA) recombination scheme. The angle between these axes, ∆R$_{axis}$, probes a wide phase space of the jet formation and evolution, ranging from the initial high-momentum-transfer scattering to the hadronization process. The ∆R$_{axis}$ observable is presented for 20 <${p}_{\textrm{T}}^{\textrm{ch}\ \textrm{jet}}$< 100 GeV/c, and compared to predictions from the PYTHIA 8 and Herwig 7 event generators. The distributions can also be calculated analytically with a leading hadronization correction related to the non-perturbative component of the Collins-Soper-Sterman (CSS) evolution kernel. Comparisons to analytical predictions at next-to-leading-logarithmic accuracy with leading hadronization correction implemented from experimental extractions of the CSS kernel in Drell-Yan measurements are presented. The analytical predictions describe the measured data within 20% in the perturbative regime, with surprising agreement in the non-perturbative regime as well. These results are compatible with the universality of the CSS kernel in the context of jet substructure.[graphic not available: see fulltext]This article reports measurements of the angle between differently defined jet axes in pp collisions at $\sqrt{s} = 5.02$ TeV carried out by the ALICE Collaboration. Charged particles at midrapidity are clustered into jets with resolution parameters $R=0.2$ and 0.4. The jet axis, before and after Soft Drop grooming, is compared to the jet axis from the Winner-Takes-All (WTA) recombination scheme. The angle between these axes, $\Delta R_{\mathrm{axis}}$, probes a wide phase space of the jet formation and evolution, ranging from the initial high-momentum-transfer scattering to the hadronization process. The $\Delta R_{\mathrm{axis}}$ observable is presented for $20 < {p_{\mathrm{T}}^{\mathrm{ch\; jet}}}< 100$ GeV/$c$, and compared to predictions from the PYTHIA 8 and Herwig 7 event generators. The distributions can also be calculated analytically with a leading hadronization correction related to the non-perturbative component of the Collins$-$Soper$-$Sterman (CSS) evolution kernel. Comparisons to analytical predictions at next-to-leading-logarithmic accuracy with leading hadronization correction implemented from experimental extractions of the CSS kernel in Drell$-$Yan measurements are presented. The analytical predictions describe the measured data within 20% in the perturbative regime, with surprising agreement in the non-perturbative regime as well. These results are compatible with the universality of the CSS kernel in the context of jet substructure

Investigation of <math><mrow><msup><mi>K</mi><mo>+</mo></msup><msup><mi>K</mi><mo>−</mo></msup></mrow></math> interactions via femtoscopy in Pb-Pb collisions at <math><mrow><msqrt><msub><mi>s</mi><mrow><mi>N</mi><mi>N</mi></mrow></msub></msqrt><mo>=</mo><mn>2.76</mn></mrow></math> TeV at the CERN Large Hadron Collider

Femtoscopic correlations of nonidentical charged kaons (K+K−) are studied in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision sNN=2.76 TeV by ALICE at the CERN Large Hadron Collider. One-dimensional K+K− correlation functions are analyzed in three centrality classes and eight intervals of particle-pair transverse momentum. The Lednický and Luboshitz interaction model used in the K+K− analysis includes the final-state Coulomb interactions between kaons and the final-state interaction through a0(980) and f0(980) resonances. The mass of f0(980) and coupling were extracted from the fit to K+K− correlation functions using the femtoscopic technique. The measured mass and width of the f0(980) resonance are consistent with other published measurements. The height of the ϕ(1020) meson peak present in the K+K− correlation function rapidly decreases with increasing source radius, qualitatively in agreement with an inverse volume dependence. A phenomenological fit to this trend suggests that the ϕ(1020) meson yield is dominated by particles produced directly from the hadronization of the system. The small fraction subsequently produced by final-state interactions could not be precisely quantified with data presented in this paper and will be assessed in future work.Femtoscopic correlations of non-identical charged kaons ($\rm K^+ K^-$) are studied in Pb$-$Pb collisions at a center-of-mass energy per nucleon$-$nucleon collision $\sqrt{s_{\mathrm{NN}}} =2.76$ TeV by ALICE at the LHC. One-dimensional $\rm K^+ K^-$ correlation functions are analyzed in three centrality classes and eight intervals of particle-pair transverse momentum. The Lednický and Luboshitz interaction model used in the $\rm K^+ K^-$ analysis includes the final-state Coulomb interactions between kaons and the final-state interaction through $a_{0}$(980) and $f_{0}$(980) resonances. The mass of $f_{0}$(980) and coupling were extracted from the fit to $\rm K^+ K^-$ correlation functions using the femtoscopic technique. The measured mass and width of the $f_{0}$(980) resonance are consistent with other published measurements. The height of the $\phi$(1020) meson peak present in the $\rm K^+ K^-$ correlation function rapidly decreases with increasing source radius, qualitatively in agreement with an inverse volume dependence. A phenomenological fit to this trend suggests that the $\phi$(1020) meson yield is dominated by particles produced directly from the hadronization of the system. The small fraction subsequently produced by final-state interactions could not be precisely quantified with data presented in this paper and will be assessed in future work