90 research outputs found

    Where Does the Alignment Score Distribution Shape Come from?

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    Alignment algorithms are powerful tools for searching for homologous proteins in databases, providing a score for each sequence present in the database. It has been well known for 20 years that the shape of the score distribution looks like an extreme value distribution. The extremely large number of times biologists face this class of distributions raises the question of the evolutionary origin of this probability law

    Margaret O. Dayhoff 1925-1983

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    Aligning DNA sequences using dynamic programming

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