507 research outputs found
The one-component plasma: a conceptual approach
The one-component plasma (OCP) represents the simplest statistical mechanical
model of a Coulomb system. For this reason, it has been extensively studied
over the last forty years. The advent of the integral equations has resulted in
a dramatic improvement in our ability to carry out numerical calculations, but
came at the expense of a physical insight gained in a simpler analytic theory.
In this paper we present an extension of the Debye-Hueckel (DH) theory to the
OCP. The theory allows for analytic calculations of all the thermodynamic
functions, as well as the structure factor. The theory explicitly satisfies the
Stillinger-Lovett and, for small couplings, the compressibility sum rules,
implying its internal self consistency.Comment: 28 pages, 5 Postscript figures, uses elsart.sty, accepted for
publication in Physica
Density-functional theory for attraction between like-charged plates
We study the interactions between two negatively charged macroscopic surfaces
confining positive counterions. A density-functional approach is introduced
which, besides the usual mean-field interactions, takes into account the
correlations in the positions of counterions. The excess free energy is derived
in the framework of the Debye-H{\"u}ckel theory of the one-component plasma,
with the homogeneous density replaced by a weighted density. The minimization
of the total free energy yields the density profile of the microions. The
pressure is calculated and compared with the simulations and the results
derived from integral equations theories. We find that the interaction between
the two plates becomes attractive when their separation distance is
sufficiently small and the surface charge density is larger than a threshold
value.Comment: 7 pages, 4 Postscript figures, uses multicol.st
Thermodynamics of Electrolytes on Anisotropic Lattices
The phase behavior of ionic fluids on simple cubic and tetragonal
(anisotropic) lattices has been studied by grand canonical Monte Carlo
simulations. Systems with both the true lattice Coulombic potential and
continuous-space electrostatic interactions have been investigated. At
all degrees of anisotropy, only coexistence between a disordered low-density
phase and an ordered high-density phase with the structure similar to ionic
crystal was found, in contrast to recent theoretical predictions. Tricritical
parameters were determined to be monotonously increasing functions of
anisotropy parameters which is consistent with theoretical calculations based
on the Debye-H\"uckel approach. At large anisotropies a two-dimensional-like
behavior is observed, from which we estimated the dimensionless tricritical
temperature and density for the two-dimensional square lattice electrolyte to
be and .Comment: submitted to PR
Monte Carlo simulation of a two-dimensional continuum Coulomb gas
We study the classical two-dimensional Coulomb gas model for thermal vortex
fluctuations in thin superconducting/superfluid films by Monte Carlo simulation
of a grand canonical vortex ensemble defined on a continuum. The
Kosterlitz-Thouless transition is well understood at low vortex density, but at
high vortex density the nature of the phase diagram and of the vortex phase
transition is less clear. From our Monte Carlo data we construct phase diagrams
for the 2D Coulomb gas without any restrictions on the vortex density. For
negative vortex chemical potential (positive vortex core energy) we always find
a Kosterlitz-Thouless transition. Only if the Coulomb interaction is
supplemented with a short-distance repulsion, a first order transition line is
found, above some positive value of the vortex chemical potential.Comment: 10 pages RevTeX, 7 postscript figures included using eps
The Persistence Length of a Strongly Charged, Rod-like, Polyelectrolyte in the Presence of Salt
The persistence length of a single, intrinsically rigid polyelectrolyte
chain, above the Manning condensation threshold is investigated theoretically
in presence of added salt. Using a loop expansion method, the partition
function is consistently calculated, taking into account corrections to
mean-field theory. Within a mean-field approximation, the well-known results of
Odijk, Skolnick and Fixman are reproduced. Beyond mean-field, it is found that
density correlations between counterions and thermal fluctuations reduce the
stiffness of the chain, indicating an effective attraction between monomers for
highly charged chains and multivalent counterions. This attraction results in a
possible mechanical instability (collapse), alluding to the phenomenon of DNA
condensation. In addition, we find that more counterions condense on slightly
bent conformations of the chain than predicted by the Manning model for the
case of an infinite cylinder. Finally, our results are compared with previous
models and experiments.Comment: 13 pages, 2 ps figure
High-throughput Proteomics Identifies THEMIS2 as Independent Biomarker of Treatment-free Survival in Untreated CLL
It remains challenging in chronic lymphocytic leukemia (CLL) to distinguish between patients with favorable and unfavorable time-to-first treatment (TTFT). Additionally, the downstream protein correlates of well-known molecular features of CLL are not always clear. To address this, we selected 40 CLL patients with TTFT ≤24 months and compared their B cell intracellular protein expression with 40 age- and sex-matched CLL patients with TTFT >24 months using mass spectrometry. In total, 3268 proteins were quantified in the cohort. Immunoglobulin heavy-chain variable (IGHV) mutational status and trisomy 12 were most impactful on the CLL proteome. Comparing cases to controls, 5 proteins were significantly upregulated, whereas 3 proteins were significantly downregulated. Of these, only THEMIS2, a signaling protein acting downstream of the B cell receptor, was significantly associated with TTFT, independently of IGHV and TP53 mutational status (hazard ratio, 2.49 [95% confidence interval, 1.62-3.84]; P < 0.001). This association was validated on the mRNA and protein level by quantitative polymerase chain reaction and ELISA, respectively. Analysis of 2 independently generated RNA sequencing and mass spectrometry datasets confirmed the association between THEMIS2 expression and clinical outcome. In conclusion, we present a comprehensive characterization of the proteome of untreated CLL and identify THEMIS2 expression as a putative biomarker of TTFT.</p
Measurement of the residual energy of muons in the Gran Sasso underground Laboratories
The MACRO detector was located in the Hall B of the Gran Sasso underground
Laboratories under an average rock overburden of 3700 hg/cm^2. A transition
radiation detector composed of three identical modules, covering a total
horizontal area of 36 m^2, was installed inside the empty upper part of the
detector in order to measure the residual energy of muons. This paper presents
the measurement of the residual energy of single and double muons crossing the
apparatus. Our data show that double muons are more energetic than single ones.
This measurement is performed over a standard rock depth range from 3000 to
6500 hg/cm^2.Comment: 28 pages, 9 figure
Muon Energy Estimate Through Multiple Scattering with the Macro Detector
Muon energy measurement represents an important issue for any experiment
addressing neutrino induced upgoing muon studies. Since the neutrino
oscillation probability depends on the neutrino energy, a measurement of the
muon energy adds an important piece of information concerning the neutrino
system. We show in this paper how the MACRO limited streamer tube system can be
operated in drift mode by using the TDC's included in the QTPs, an electronics
designed for magnetic monopole search. An improvement of the space resolution
is obtained, through an analysis of the multiple scattering of muon tracks as
they pass through our detector. This information can be used further to obtain
an estimate of the energy of muons crossing the detector. Here we present the
results of two dedicated tests, performed at CERN PS-T9 and SPS-X7 beam lines,
to provide a full check of the electronics and to exploit the feasibility of
such a multiple scattering analysis. We show that by using a neural network
approach, we are able to reconstruct the muon energy for 40 GeV. The
test beam data provide an absolute energy calibration, which allows us to apply
this method to MACRO data.Comment: 25 pages, 11 figures, Submitted to Nucl. Instr. & Meth.
Measurement of the atmospheric neutrino-induced upgoing muon flux using MACRO
We present a measurement of the flux of neutrino-induced upgoing muons
(~100 GeV) using the MACRO detector. The ratio of the number of observed
to expected events integrated over all zenith angles is 0.74 +/- 0.036 (stat)
+/- 0.046(systematic) +/- 0.13 (theoretical). The observed zenith distribution
for -1.0 < cos(theta) < -0.1 does not fit well with the no oscillation
expectation, giving a maximum probability for chi^2 of 0.1%. The acceptance of
the detector has been extensively studied using downgoing muons, independent
analyses and Monte-Carlo simulations. The other systematic uncertainties cannot
be the source of the discrepancies between the data and expectations. We have
investigated whether the observed number of events and the shape of the zenith
distribution can be explained by a neutrino oscillation hypothesis. Fitting
either the flux or zenith distribution independently yields mixing parameters
of sin^2 (2theta)=1.0 and delta m^2 of a few times 10^-3 eV^2. However, the
observed zenith distribution does not fit well with any expectations giving a
maximum probability for chi^2 of 5% for the best oscillation hypothesis, and
the combined probability for the shape and number of events is 17%. We conclude
that these data favor a neutrino oscillation hypothesis, but with unexplained
structure in the zenith distribution not easily explained by either the
statistics or systematics of the experiment.Comment: 7 pages (two-column) with 4 figure
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