10 research outputs found
Two kinesin-related proteins associated with the cold-stable cytoskeleton of carrot cells: characterization of a novel kinesin, DcKRP120-2
Immunohistochemical detection of DNA topoisomerase I in formalin fixed, paraffin wax embedded normal tissues and in ovarian carcinomas.
Anti-topoisomerase drugs as potent inducers of chromosomal aberrations
DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs. Anti-topoisomerase drugs can be divided into two main classes: "cleavable complex" poisons and catalytic inhibitors. The "cleavable complex" poisons are very effective as anticancer drugs but are also potent inducers of chromosome aberrations so they can cause secondary malignancies. Catalytic inhibitors are cytotoxic but they do not induce chromosome aberrations. Knowledge about the mechanism of action of topoisomerase inhibitors is important to determine the best anti-topoisomerase combinations, with a reduced risk of induction of secondary malignancies.<br>As topoisomerases de DNA catalisam alterações topolĂłgicas no DNA que sĂŁo essenciais para a progressĂŁo do ciclo celular normal e, portanto, sĂŁo um alvo preferencial para o desenvolvimento de drogas anticâncer. Drogas anti-topoisomerases podem ser divididas em duas classes principais: drogas anti-"complexos cliváveis" e inibidores catalĂticos. As drogas anti-"complexos cliváveis" sĂŁo muito eficazes como drogas anticancerĂgenas, mas sĂŁo tambĂ©m potentes indutores de aberrações cromossĂ´micas, podendo causar neoplasias malignas secundárias. Inibidores catalĂticos sĂŁo citotĂłxicos mas nĂŁo induzem aberrações cromossĂ´micas. Conhecimento a respeito do mecanismo de ação de inibidores de topoisomerases Ă© importante para determinar as melhores combinações anti-topoisomerases, com um reduzido risco de indução de neoplasias malignas secundárias