Estudo histopatológico de lesões ateroscleróticas em suínos de raça Alentejana.

Neste trabalho experimental procedeu-se à medição da espessura e à caracterização histológica de lesões ateroscleróticas, em suínos de raça Alentejana, procurando-se estabelecer uma relação entre estas e os valores dos parâmetros sanguíneos associados ao desenvolvimento deste processo patológico. As concentrações plasmáticas de triacilgliceróis, fosfolípidos, colesterol total, colesterol livre, LDLc e HDLc foram determinadas por métodos enzimáticos. Foram também feitas análises histopatológicas a amostras da artéria coronária esquerda. Os animais foram divididos em 2 grupos de 6 indivíduos cada: Grupo I, com elevada colesterolémia (4,25 mmol/L) e Grupo II, com níveis normais (2,53 mmol/L). Os valores do ganho médio diário (GMD) dos dois grupos foram semelhantes. Os animais do Grupo apresentaram valores significativamente mais elevados (P≤0,001) para: colesterol total, colesterol livre, colesterol esterificado e LDLc. A área de lesão foi significativamente superior (P≤0,05) no Grupo I. Verificou-se uma relação linear entre a área de lesão (fases iniciais do tipo I e II) e os teores plasmáticos de colesterol total, de LDLc e de colesterol livre, o que sugere a influência destes parâmetros na dimensão da área de lesão. Os resultados deste trabalho sugerem que os suínos de raça Alentejana podem desenvolver lesões ateroscleróticas ao longo do seu ciclo de vida, tal como o observado em humanos e outras raças de suínos. Estas lesões estão associadas a hipercolesterolemia que poderão ser devidas a mutações genéticas em apolipoproteínas, sistemas enzimáticos ou receptores. São necessários estudos futuros, quer a nível histológico quer a nível de biologia molecular, para um maior aprofundamento do conhecimento das lesões ateroscleróticas em suínos de raça Alentejana. The present study aimed to assess the histopathological characterization of atherosclerotic lesions in Alentejano pigs, and to evaluate the relationship between several blood parameters and lesions development. Histomorphometric determinations of atherosclerotic lesions were performed on the left coronary artery and plasmatic levels of triacylglycerols, phospholipids, and of total, free, LDL and HDL cholesterol were measured by enzymatic methods. Pigs were assigned to two groups (n=6): Group I, with hypercholesterolemic pigs (4,25 mmol/L), and Group II, with normocholesterolemic ones (2,53 mmol/L). Average daily gain was similar in both groups. Plasmatic levels of total, free, esterified and LDL cholesterol were significantly higher (P≤0,001) in Group I. The atherosclerotic lesion area was significantly higher (P≤0,05) in the same group. Linear correlations between atherosclerotic lesion area (in initial Phases I and II) and plasmatic levels of total, free and LDL cholesterol were observed. The results of this study suggest that the Alentejano pig, like humans and other swine, may develop atherosclerotic lesions during its life cycle. Such lesions, associated with hypercholesterolemia, may be due to genetic mutations in apolipoproteins, lipid enzymes or receptor genes. Further studies on molecular genetics and on hysthopathology of this type of atherosclerostic lesion, in Alentejano pigs are required

Gamma irradiation preservation of chestnut fruits: effects on color and texture

Chestnuts are a seasonal fruit that must be postharvest treated to meet food safety regulations. In this study the effect of gamma irradiation on color and texture of chestnut fruits from a European variety (Castanea sativa Miller) was reported. The fruits were subjected to gamma irradiation doses of 0.5, 3 and 6 kGy, with color and texture properties analyzed along a typical commercial period for this fruit after postharvest treatment, at 0, 15 and 30 days of storage. For L and b color parameters, significant differences (p < 0.05) were observed with irradiation dose (ID) only for higher doses of 3 kGy and 6 kGy. Along storage time (ST) significant differences (p < 0.05) were observed for fruits interior (half-cutted) after 15 days of storage. Regarding texture, differences on fruits were only detected for chestnuts irradiated with 6 kGy. With this study we can identify the maximum acceptable dose for irradiation processing of these fruits, concluding that gamma irradiation could be a promising alternative technology for postharvest disinfestation of European chestnuts varieties, to meet food safety international trade regulations, not affecting significantly two important parameters for the consumer, the color and texture

Finite Temperature Systems of Brane-Antibrane on a Torus

In order to study the thermodynamic properties of brane-antibrane systems in the toroidal background, we compute the finite temperature effective potential of tachyon T in this system on the basis of boundary string field theory. We first consider the case that all the radii of the target space torus are about the string scale. If the Dp-antiDp pair is extended in all the non-compact directions, the sign of the coefficient of |T|^2 term of the potential changes slightly below the Hagedorn temperature. This means that a phase transition occurs near the Hagedorn temperature. On the other hand, if the Dp-antiDp pair is not extended in all the non-compact directions, the coefficient is kept negative, and thus a phase transition does not occur. Secondly, we consider the case that some of the radii of the target space torus are much larger than the string scale and investigate the behavior of the potential for each value of the radii and the total energy. If the Dp-antiDp pair is extended in all the non-compact directions, a phase transition occurs for large enough total energy.Comment: 23 pages, 3 figures, minor errors corrected, version to appear in JHE

Planck scale effects in neutrino physics

We study the phenomenology and cosmology of the Majoron (flavon) models of three active and one inert neutrino paying special attention to the possible (almost) conserved generalization of the Zeldovich-Konopinski-Mahmoud lepton charge. Using Planck scale physics effects which provide the breaking of the lepton charge, we show how in this picture one can incorporate the solutions to some of the central issues in neutrino physics such as the solar and atmospheric neutrino puzzles, dark matter and a 17 keV neutrino. These gravitational effects induce tiny Majorana mass terms for neutrinos and considerable masses for flavons. The cosmological demand for the sufficiently fast decay of flavons implies a lower limit on the electron neutrino mass in the range of 0.1-1 eV.Comment: 24 pages, 1 figure (not included but available upon request), LaTex, IC/92/196, SISSA-140/92/EP, LMU-09/9

Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Volume I. Introduction to DUNE

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology