Impact of Plasmodium Falciparum Parasitaemia on packed cell volume among Children (6-59 months) attending bulumkutu comprehensive health center maiduguri, Borno State – Nigeria

 This study was conducted to assess the influence of Plasmodium falciparum parasitaemia on PCV Packed Cell Volume in (children) (6-59), at Bulumkutu Comprehensive Health Center Maiduguri, Borno State, between August to December, 2019. A total of 210 children were enrolled in the study which consisted of 88 (41.9%) patients with positive P. falciparum malaria and 122 (58.10%) negative malaria. Hematological parameters were analyzed using sysmexhaematology auto-analyser (2011), while the Giemsa stained slides thick and thin blood films were prepared from the stock solution, and tested for Plasmodium falciparummalaria and count of malaria parasite density. The result shows that a mean parked cell volume. countswere significantly lower compared to malaria negative individual. A negative and significant orre1a1ion was observed between the parasite densities parked cell volumes index of anaemia of subject. (r2 0.508, p 0.005) and also in male subject.(r2 0.680, p 0.005) while the parked cell volume and count female subjects (r2 0.537, p 0.005) respectively

Granunolocytic responses to Parasitaemia of Plasmodium Falciparum Species in children (6-59 months) attending bulumktu comprehensive health center, Maiduguri, Borno State – Nigeria

This study was conducted to assess the influence of Plasmodium falciparum parasitaemia on eosinophil and neutrophil in children (6-59months), at BulumkutuComprehensive Health Centre, Maiduguri, Bono State, between August to December 2018. A total of 210 children were enrolled in the study which consisted of 88 (41.90%) patients with positive P. falciparum malaria and 122 (58.10%) negative malaria. Hematological parameters were analyzed using sysmexhaematology auto-analyzer (2011), while the Giemsa stained slides thick and thin blood films were prepared from the stock solution, and tested for Plasmodium falciparum malaria and count of malaria parasite density. This study indicated that there was a positive correlation between parasite densities and granulocytes (neutrophil and eosinophil) of the malaria-infected subjects, as well as malaria infected males and females subjects respectively. (r2 = 0.63 5, p = 0.005), (r2 = 0.5 10, p = 0.005), (r2 = 0.602, p = 0.005), (r2 = 0.504, p 0.005), and (r2 = 0.890, p = 0.001), (r2 = 0.623, p = 0.005)

In Vitro Assessment of anti plasmodial activity of Albizia chevalieri extracts against Plasmodium falciparum

Medicinal plants play a key role in malaria control in Africa, especially in remote areas where health facilities are limited. This study was carried out with the aim to investigate the anti plasmodial activity of Albizia chevalieri against Plasmodium falciparum. The three aerial parts of Albizia chevalieri were extracted using methanol via maceration process. Anti plasmodial assay was carried out in duplicate in the 96-well microtitre plate. The anti Plasmodial activity of A. chevalieri methanolic extracts observed in this study may be attributed to the presence of some bioactive compounds. The effect of A. chevalieri methanolic extracts and reference drugs showed a decrease in percentage parasitaemia with increasing concentration. With regard to concentrations administered, a dose-dependent antimalarial activity was clearly shown for crude extract, isolates and the reference drugs. Artemether, the root isolate and leaf isolate exhibited a remarkable antiplasmodial activity. Root, leaf extracts and the pure isolates when compared with the standard drug that has the highest percentage inhibition shows no significance difference at (P>0.05). However, when compared with the other drugs such as Chloroquine, Quinine shows a significance percentage inhibition difference at (P>0.05). Considering the inhibitory effect of A. chevalieri methanol extracts on the growth of P. falciparum as reported in this study, it is concluded that the anti plasmodial activity of the plant on P. falciparum suggests its potency in the treatment of malaria infection. Further study on this plant is on-going to isolate, identify and characterize the bioactive compounds from this plant responsible for this bioactivity, and also to carry- out the drug synthesis