19 research outputs found
Pulse Shape Analysis and Identification of Multipoint Events in a Large-Volume Proportional Counter in an Experimental Search for 2K Capture Kr-78
A pulse shape analysis algorithm and a method for suppressing the noise
component of signals from a large copper proportional counter in the experiment
aimed at searching for 2K capture of Kr-78 are described. These signals
correspond to a compound event with different numbers of charge clusters due to
from primary ionization is formed by these signals. A technique for separating
single- and multipoint events and determining the charge in individual clusters
is presented. Using the Daubechies wavelets in multiresolutional signal
analysis, it is possible to increase the sensitivity and the resolution in
extraction of multipoint events in the detector by a factor of 3-4.Comment: 10 pages, 8 figures. submitted to Instruments and Experimental
Techniques; ISSN 0020/441
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4ι P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4ι are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4ι-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4ι-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH
Reaction of 8-chloro-5,7-dinitroquinoline with β-dicarbonyl compounds
3-(5,7-Dinitroquinolin-8-yl)pentane-2,4-dione, 5-(5,7-dinitroquinolin-8-yl)pyrimidine-2,4,6-trione, and 5-(5,7-dinitroquinolin-8-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione cesium salts have been synthesized by a simple and efficient procedure via C-arylation of the corresponding β-dicarbonyl compounds with 8-chloro-5,7-dinitroquinoline. Š 2017, Pleiades Publishing, Ltd
Reaction of 8-chloro-5,7-dinitroquinoline with β-dicarbonyl compounds
3-(5,7-Dinitroquinolin-8-yl)pentane-2,4-dione, 5-(5,7-dinitroquinolin-8-yl)pyrimidine-2,4,6-trione, and 5-(5,7-dinitroquinolin-8-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione cesium salts have been synthesized by a simple and efficient procedure via C-arylation of the corresponding β-dicarbonyl compounds with 8-chloro-5,7-dinitroquinoline. Š 2017, Pleiades Publishing, Ltd