Study of limit strains for FCC and BCC sheet metal using polycrystal plasticity

AbstractIn this research, we analyze forming-limit strains of FCC and BCC materials using a viscoplastic self-consistent polycrystal model (VPSC) in conjunction with the Marciniak–Kuczynski (MK) approach. In particular, our work is focused on the theoretical analysis and comparison between FCC and BCC crystal structures made by Inal et al. [Inal, K., Neale, K.W., Aboutajeddine, A., 2005. Forming limit comparison for FCC and BCC sheets, International Journal of Plasticity, 21, 1255–1266]. These authors performed their simulations based on a generalized Taylor-type polycrystal model (MK-FC), finding a remarkably low forming-limit curve for the FCC material and an extremely high forming-limit curve for the BCC material, in the biaxial stretching range. We verified that our predictions are similar to Inal’s results for both FCC and BCC materials when the MK-FC model is used. However, MK-VPSC calculations do not give such extreme values, and we believe that this theory predicts much more reliable results for both FCC and BCC crystallographic assumptions. We also found that localized necking depends on texture evolution in the vicinity of equi-biaxial stretching, through the sharpness of the predicted yield surface. Finally, it is shown that the MK-VPSC’s predictions are in good agreement with experimental data for AA5182-O and a DQ-type steel-sheet metal

Usage of standardized antigen-presenting cells improves ELISpot performance for complex protein antigens

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Usage of standardized antigen-presenting cells improves ELISpot performance for complex protein antigens

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma

Idiotype vaccination for follicular lymphoma is primarily being developed as remission consolidation after chemotherapy. We investigated idiotype vaccination as primary intervention for treatment-naive indolent B-cell lymphoma and in a separate cohort as remission consolidation after chemotherapy to assess immunization-induced immune responses in relation to progression-free survival (German Clinical Trials Register, DRKS00000227). Twenty-one patients in each cohort received 6 intradermal injections of adjuvanted recombinant idiotype Fab fragment (Fab(Id)); 76% of patients in both groups developed anti-idiotype antibodies and/or cellular immunity as measured by enzyme-linked immunosorbent assay and interferon-gamma ELISpot. In treatment-naive patients, only cellular responses correlated with superior progression-free survival (P < .002) and durable objective remissions (P = .04). Immunization-induced T cells recognized hypermutated or complementarity-determining region 3 epitopes. After remission consolidation immunization, induction of anti-idiotype antibodies correlated with progression-free survival. Low B-cell counts after rituximab therapy predicted for failure to develop anti-idiotype antibodies. These results are similar to published trials showing an association of humoral immunity with control of residual lymphoma. In contrast, effective immunity against untreated lymphoma appears to be dependent on idiotype-specific T cells. Sustained remissions in patients with vaccination-induced cellular immunity suggest clinical benefit and warrant a randomized comparison of this vaccine with expectant management for asymptomatic follicular lymphoma. (Blood. 2011; 117(5): 1483-1491)Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Selection patterns of B-cell receptors and the natural history of follicular lymphoma

HematologyImmunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease