Monitoring the emergence of antibiotic resistance using the technology ot the DebugIT platform in the HEGP context

International audiencepas de résum

A method for obtaining Darboux transformations

In this paper we give a method to obtain Darboux transformations (DTs) of integrable equations. As an example we give a DT of the dispersive water wave equation. Using the Miura map, we also obtain the DT of the Jaulent-Miodek equation. \end{abstract

Inverse spectral problems for energy-dependent Sturm-Liouville equations

We study the inverse spectral problem of reconstructing energy-dependent Sturm-Liouville equations from their Dirichlet spectra and sequences of the norming constants. For the class of problems under consideration, we give a complete description of the corresponding spectral data, suggest a reconstruction algorithm, and establish uniqueness of reconstruction. The approach is based on connection between spectral problems for energy-dependent Sturm-Liouville equations and for Dirac operators of special form.Comment: AMS-LaTeX, 28 page

Quantitative analysis of manual annotation of clinical text samples

International audienceBackground: Semantic interoperability of eHealth services within and across countries has been the main topic in several research projects. It is a key consideration for the European Commission to overcome the complexity of making different health information systems work together. This paper describes a study within the EU-funded project ASSESS CT, which focuses on assessing the potential of SNOMED CT as core reference terminology for semantic interoperability at European level.Objective: This paper presents a quantitative analysis of the results obtained in ASSESS CT to determine the fitness of SNOMED CT for semantic interoperability.Methods: The quantitative analysis consists of concept coverage, term coverage and inter-annotator agreement analysis of the annotation experiments related to six European languages (English, Swedish, French, Dutch, German and Finnish) and three scenarios: (i) ADOPT, where only SNOMED CT was used by the annotators; (ii) ALTERNATIVE, where a fixed set of terminologies from UMLS, excluding SNOMED CT, was used; and (iii) ABSTAIN, where any terminologies available in the current national infrastructure of the annotators' country were used. For each language and each scenario, we configured the different terminology settings of the annotation experiments.Results: There was a positive correlation between the number of concepts in each terminology setting and their concept and term coverage values. Inter-annotator agreement is low, irrespective of the terminology setting.Conclusions: No significant differences were found between the analyses for the three scenarios, but availability of SNOMED CT for the assessed language is associated with increased concept coverage. Terminology setting size and concept and term coverage correlate positively up to a limit where more concepts do not significantly impact the coverage values. The results did not confirm the hypothesis of an inverse correlation between concept coverage and IAA due to a lower amount of choices available. The overall low IAA results pose a challenge for interoperability and indicate the need for further research to assess whether consistent terminology implementation is possible across Europe, e.g., improving term coverage by adding localized versions of the selected terminologies, analysing causes of low inter-annotator agreement, and improving tooling and guidance for annotators. The much lower term coverage for the Swedish version of SNOMED CT compared to English together with the similarly high concept coverage obtained with English and Swedish SNOMED CT reflects its relevance as a hub to connect user interface terminologies and serving a variety of user needs

Gurevich-Zybin system

We present three different linearizable extensions of the Gurevich-Zybin system. Their general solutions are found by reciprocal transformations. In this paper we rewrite the Gurevich-Zybin system as a Monge-Ampere equation. By application of reciprocal transformation this equation is linearized. Infinitely many local Hamiltonian structures, local Lagrangian representations, local conservation laws and local commuting flows are found. Moreover, all commuting flows can be written as Monge-Ampere equations similar to the Gurevich-Zybin system. The Gurevich-Zybin system describes the formation of a large scale structures in the Universe. The second harmonic wave generation is known in nonlinear optics. In this paper we prove that the Gurevich-Zybin system is equivalent to a degenerate case of the second harmonic generation. Thus, the Gurevich-Zybin system is recognized as a degenerate first negative flow of two-component Harry Dym hierarchy up to two Miura type transformations. A reciprocal transformation between the Gurevich-Zybin system and degenerate case of the second harmonic generation system is found. A new solution for the second harmonic generation is presented in implicit form.Comment: Corrected typos and misprint

C3-Cloud personalised care plan development platform for addressing the needs of multi-morbidity and managing poly-pharmacy : protocol for a pilot technology trial

Background: There is an increasing need to organise the care around the patient and not the disease, as well as taking into account the complex realities of multiple physical, psycho-social conditions and polypharmacy. Integrated patient-centred care delivery platforms have been developed for both patients and clinicians. These platforms could provide a promising way to achieve a collaborative environment that improves the provision of integrated care for patients via enhanced ICT solutions. Objective: The C3-Cloud project has developed two collaborative computer platforms for patients and members of the Multi-Disciplinary Team and deployed these in three different European settings. The objective of this study is to pilot test the platforms and evaluate their impact on patients, informal caregivers, healthcare professionals and, in extend, healthcare systems. Methods: This paper describes the protocol for conducting an evaluation of the user-centred design, user experience, acceptability, and usefulness of the platforms. For this, four ‘testing and evaluation’ phases have been defined, involving multiple qualitative methods, and advanced impact modelling. Results: The technology trial in this 4-year funded project (2016-2020) is currently in its execution phase. The testing and evaluation phase 1 and 2 have been completed with satisfying results on system component tests, and promising results on application and usability tests. The pilot technology trial for evaluation phase 3 and 4 was launched in August 2019. Data collection for these phases is underway and results are forthcoming, approximately in April 2020. We believe that the phased, iterative approach taken is useful as it involves relevant stakeholders at crucial stages in the platform development and allows for a sound user acceptance assessment of the final product. Conclusions: Patients with multiple chronic conditions often experience shortcomings in the care they receive. It is hoped that personalised care plan platforms for patients and collaboration platforms for members of Multi-Disciplinary Teams can help to tackle the specific challenges of clinical guideline reconciliation for multimorbid patients and improved the management of poly-pharmacy. The initial evaluative phases have indicated promising results of platform usability. The phased methodology has shown useful results in the first two phases, while results of phase 3 and 4 are pending. Clinical Trial: https://www.clinicaltrials.gov/ct2/show/NCT0383420