375 research outputs found
Large microwave generation from d.c. driven magnetic vortex oscillators in magnetic tunnel junctions
Spin polarized current can excite the magnetization of a ferromagnet through
the transfer of spin angular momentum to the local spin system. This pure
spin-related transport phenomena leads to alluring possibilities for the
achievement of a nanometer scale, CMOS compatible and tunable microwave
generator operating at low bias for future wireless communications. Microwave
emission generated by the persitent motion of magnetic vortices induced by spin
transfer effect seems to be a unique manner to reach appropriate spectral
linewidth. However, in metallic systems, where such vortex oscillations have
been observed, the resulting microwave power is much too small. Here we present
experimental evidences of spin-transfer induced core vortex precessions in
MgO-based magnetic tunnel junctions with similar good spectral quality but an
emitted power at least one order of magnitude stronger. More importantly,
unlike to others spin transfer excitations, the thorough comparison between
experimental results and models provide a clear textbook illustration of the
mechanisms of vortex precessions induced by spin transfer
Microwave neural processing and broadcasting with spintronic nano-oscillators
Can we build small neuromorphic chips capable of training deep networks with
billions of parameters? This challenge requires hardware neurons and synapses
with nanometric dimensions, which can be individually tuned, and densely
connected. While nanosynaptic devices have been pursued actively in recent
years, much less has been done on nanoscale artificial neurons. In this paper,
we show that spintronic nano-oscillators are promising to implement analog
hardware neurons that can be densely interconnected through electromagnetic
signals. We show how spintronic oscillators maps the requirements of artificial
neurons. We then show experimentally how an ensemble of four coupled
oscillators can learn to classify all twelve American vowels, realizing the
most complicated tasks performed by nanoscale neurons
Crossover from Kondo assisted suppression to co-tunneling enhancement of tunneling magnetoresistance via ferromagnetic nanodots in MgO tunnel barriers
Recently, it has been shown that magnetic tunnel junctions with thin MgO
tunnel barriers exhibit extraordinarily high tunneling magnetoresistance (TMR)
values at room temperature1, 2. However, the physics of spin dependent
tunneling through MgO barriers is only beginning to be unravelled. Using planar
magnetic tunnel junctions in which ultra-thin layers of magnetic metals are
deposited in the middle of a MgO tunnel barrier here we demonstrate that the
TMR is strongly modified when these layers are discontinuous and composed of
small pancake shaped nanodots. At low temperatures, in the Coulomb blockade
regime, for layers less than ~1 nm thick, the conductance of the junction is
increased at low bias consistent with Kondo assisted tunneling. In the same
regime we observe a suppression of the TMR. For slightly thicker layers, and
correspondingly larger nanodots, the TMR is enhanced at low bias, consistent
with co-tunneling.Comment: Nano Letters (in press
Proportion of intracerebral haemorrhage due to cerebral amyloid angiopathy in the East and West: Comparison between single hospital centres in Japan and the United Kingdom
PURPOSE: We investigated whether the proportion of intracerebral haemorrhage (ICH) due to cerebral amyloid angiopathy (CAA) differs between patients admitted to hospitals in the East and the West. METHODS: This international cross-sectional study included consecutive spontaneous ICH patients admitted to one stroke centre in the United Kingdom (Western centre origin) and one in Japan (Eastern centre origin) during the same period. We classified spontaneous ICH into "CAA-related" or "other" using the Edinburgh CT-based diagnostic criteria. We used multivariable logistic regression analyses to assess the relationship between CAA-related ICH and geographical location or ethnicity (White vs. East Asian or other ethnicities). Sensitivity analyses were performed using the modified Boston MRI-based diagnostic criteria for CAA-related ICH. RESULTS: Of 433 patients (median age, 72 years; Western centre origin, 55%), 15% were classified as CAA-related ICH. In the multivariable logistic regression model, Eastern centre and ethnicity had a lower proportion of CAA-related ICH (odds ratio [OR] vs Western centre origin 0.55, 95%CI 0.31-0.98; OR [vs. White] 0.47, 95%CI 0.25-0.87); these findings remained robust in sensitivity analyses. The estimated incidence of "other" (non-CAA) ICH (attributed to hypertensive arteriopathy) was 2.5-fold higher in East Asian populations. CONCLUSIONS: The proportion CAA-related ICH is lower in an Eastern compared to a Western hospital ICH population; this might be explained by a higher incidence of ICH related to hypertensive arteriopathy in East Asian populations, suggesting that optimal ICH prevention strategies might differ between the East and West
Spin Diode Based on Fe/MgO Double Tunnel Junction
We demonstrate a spin diode consisting of a semiconductor free nano-scale
Fe/MgO-based double tunnel junction. The device exhibits a near perfect
spin-valve effect combined with a strong diode effect. The mechanism consistent
with our data is resonant tunneling through discrete states in the middle
ferromagnetic layer sandwiched by tunnel barriers of different spin-dependent
transparency. The observed magneto-resistance is record high, ~4000%,
essentially making the structure an on/off spin-switch. This, combined with the
strong diode effect, ~100, offers a new device that should be promising for
such technologies as magnetic random access memory and re-programmable logic.Comment: 14 page
Spin torque resonant vortex core expulsion for an efficient radio-frequency detection scheme
Spin-polarised radio-frequency currents, whose frequency is equal to that of
the gyrotropic mode, will cause an excitation of the core of a magnetic vortex
confined in a magnetic tunnel junction. When the excitation radius of the
vortex core is greater than that of the junction radius, vortex core expulsion
is observed, leading to a large change in resistance, as the layer enters a
predominantly uniform magnetisation state. Unlike the conventional spin-torque
diode effect, this highly tunable resonant effect will generate a voltage which
does not decrease as a function of rf power, and has the potential to form the
basis of a new generation of tunable nanoscale radio-frequency detectors
Pseudomyxoma peritonei – two novel orthotopic mouse models portray the PMCA-I histopathologic subtype
<p>Abstract</p> <p>Background</p> <p>Pseudomyxoma peritonei (PMP) is a rare malignant disease, most commonly originating from appendiceal lesions and characterized by accumulation of mucinous tumor tissue in the peritoneal cavity. Since the disease is infrequent, the task of carrying out studies of treatment efficacy and disease biology in the clinical setting is challenging, warranting the development of relevant <it>in vitro </it>and <it>in vivo </it>PMP models.</p> <p>Methods</p> <p>Human tumor tissue was implanted in the peritoneal cavity of nude mice to establish two orthotopic models exhibiting noninvasive intraperitoneal growth without metastasis development.</p> <p>Results</p> <p>Xenograft tissues have retained essential properties of the original human tumors, such as macro- and microscopic growth patterns, mucin production as well as expression of carcinoembryonal antigen, cytokeratins 20 and 7 and the proliferation marker pKi67. Upon microscopic examination, the human tumors were categorized as the PMCA-I (peritoneal mucinous carcinomatosis of intermediate features) subtype, which was conserved through 14 examined passages in mice, for the first time modeling this particular histopathologic category.</p> <p>Conclusion</p> <p>In conclusion, two novel orthotopic models of human PMP have been established that consistently portray a distinct histopathologic subtype and reflect essential human tumor properties. Xenografts can easily and reproducibly be transferred to new generations of mice with acceptable passage periods, rendering the models as attractive tools for further studies of PMP biology and treatment.</p
Clinical analysis of Krukenberg tumours in patients with colorectal cancer—a review of 57 cases
An environment for relation mining over richly annotated corpora: the case of GENIA
BACKGROUND: The biomedical domain is witnessing a rapid growth of the amount of published scientific results, which makes it increasingly difficult to filter the core information. There is a real need for support tools that 'digest' the published results and extract the most important information. RESULTS: We describe and evaluate an environment supporting the extraction of domain-specific relations, such as protein-protein interactions, from a richly-annotated corpus. We use full, deep-linguistic parsing and manually created, versatile patterns, expressing a large set of syntactic alternations, plus semantic ontology information. CONCLUSION: The experiments show that our approach described is capable of delivering high-precision results, while maintaining sufficient levels of recall. The high level of abstraction of the rules used by the system, which are considerably more powerful and versatile than finite-state approaches, allows speedy interactive development and validation
- …