Cancer patients’ experiences of living with venous thromboembolism: A systematic review and qualitative thematic synthesis

Background: Cancer-Associated thrombosis is common. Recommended treatment is daily injected low-molecular-weight heparin for 6months. Most studies focus on prophylaxis and treatment; few have explored patients’ experience. Aims To identify and synthesise the available literature concerning patients’ experience of cancer associated thrombosis. Design Systematic literature review and qualitative thematic synthesis. MethodsMEDLINE, Embase, CINAHL, PsychINFO (until 10/2016; limited to English) were searched. Eligible papers were qualitative studies of adult patients’ experience of cancer-associated thrombosis. Two researchers screened titles/abstracts/papers against inclusion criteria with recourse to a third for disagreements. Critical Appraisal Skills Programme qualitative checklist tool was used for quality appraisal. Results1397 articles were identified. Five qualitative studies (total n=92; age range 32 to 84 years) met the inclusion criteria. Participants had various cancer types. Most had advanced disease and were receiving palliative care. Four major themes emerged from the data: knowledge deficit (patients and clinicians); effects of cancer associated thrombosis (physical and psychological); effects of anticoagulation; coping strategies. ConclusionThe cancer journey is difficult in itself, but thrombosis was an additional, frightening and unexpected burden. Although the association between cancer and thromboembolism is well known, cancer patients are not educated routinely about the risk or warning symptoms/signs of thromboembolism which may otherwise be misattributed to the cancer by patient and clinician alike. This systematic review highlights the impact of cancer-associated thrombosis on the lives of cancer patients, and calls for education for patients and clinicians to be part of routine care, and further work to address this patient priority

Channel Impulse Response-based Distributed Physical Layer Authentication

In this preliminary work, we study the problem of {\it distributed} authentication in wireless networks. Specifically, we consider a system where multiple Bob (sensor) nodes listen to a channel and report their {\it correlated} measurements to a Fusion Center (FC) which makes the ultimate authentication decision. For the feature-based authentication at the FC, channel impulse response has been utilized as the device fingerprint. Additionally, the {\it correlated} measurements by the Bob nodes allow us to invoke Compressed sensing to significantly reduce the reporting overhead to the FC. Numerical results show that: i) the detection performance of the FC is superior to that of a single Bob-node, ii) compressed sensing leads to at least $20\%$ overhead reduction on the reporting channel at the expense of a small ($<1$ dB) SNR margin to achieve the same detection performance.Comment: 6 pages, 5 figures, accepted for presentation at IEEE VTC 2017 Sprin

Enhancing Physical Layer Security in AF Relay Assisted Multi-Carrier Wireless Transmission

In this paper, we study the physical layer security (PLS) problem in the dual hop orthogonal frequency division multiplexing (OFDM) based wireless communication system. First, we consider a single user single relay system and study a joint power optimization problem at the source and relay subject to individual power constraint at the two nodes. The aim is to maximize the end to end secrecy rate with optimal power allocation over different sub-carriers. Later, we consider a more general multi-user multi-relay scenario. Under high SNR approximation for end to end secrecy rate, an optimization problem is formulated to jointly optimize power allocation at the BS, the relay selection, sub-carrier assignment to users and the power loading at each of the relaying node. The target is to maximize the overall security of the system subject to independent power budget limits at each transmitting node and the OFDMA based exclusive sub-carrier allocation constraints. A joint optimization solution is obtained through duality theory. Dual decomposition allows to exploit convex optimization techniques to find the power loading at the source and relay nodes. Further, an optimization for power loading at relaying nodes along with relay selection and sub carrier assignment for the fixed power allocation at the BS is also studied. Lastly, a sub-optimal scheme that explores joint power allocation at all transmitting nodes for the fixed subcarrier allocation and relay assignment is investigated. Finally, simulation results are presented to validate the performance of the proposed schemes.Comment: 10 pages, 7 figures, accepted in Transactions on Emerging Telecommunications Technologies (ETT), formerly known as European Transactions on Telecommunications (ETT

The impact of peripheral arterial disease on patients with mechanical circulatory support.

Background: Left ventricular assist devices (LVAD) are indicated as bridging or destination therapy for patients with advanced (Stage D) heart failure and reduced ejection fraction (HFrEF). Due to the clustering of the mutual risk factors, HFrEF patients have a high prevalence of peripheral arterial disease (PAD). This, along with the fact that continuous flow LVAD influence shear stress on the vasculature, can further deteriorate the PAD. Methods: We queried the National Inpatient Sample (NIS) database (2002-2014) to identify the burden of pre-existing PAD cases, its association with LVAD, in-hospital mortality, and other complications of LVAD. The adjusted odds ratio (aOR) and 95% confidence interval (CI) were calculated using the Cochran-Mantel-Haenszel test. Results: A total of 20,817 LVAD patients, comprising of 1,625 (7.8%) PAD and 19,192 (91.2%) non-PAD patients were included in the study. The odds of in-hospital mortality in PAD patients were significantly higher compared to non-PAD group (OR 1.29, CI, 1.07-1.55, P = 0.007). The PAD group had significantly higher adjusted odds as compared to non-PAD group for acute myocardial infarction (aOR 1.29; 95% CI, 1.07-1.55, P = 0.007), major bleeding requiring transfusion (aOR, 1.286; 95% CI, 1.136-1.456, P \u3c 0.001), vascular complications (aOR, 2.360; 95% CI, 1.781-3.126, P \u3c 0.001), surgical wound infections (aOR, 1.50; 95% CI, 1.17-1.94, P = 0.002), thromboembolic complications (aOR, 1.69; 95% CI, 1.36-2.10, P \u3c 0.001), implant-related complications (aOR, 1.47; 95% CI, 1.19-1.80, P \u3c 0.001), and acute renal failure (aOR, 1.26; 95% CI, 1.12-1.43, P \u3c 0.001). Conclusion: PAD patients can have high LVAD associated mortality as compared to non-PAD

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles.

ObjectiveAlmonds are a rich source of fatty acids and antioxidants, and their supplementation is known to significantly modulate serum lipids. The effects of almond on the skin's lipid barrier and the appearance of wrinkles have not yet been elucidated. The aim of this study was to investigate the effects of almond consumption on facial sebum production and wrinkles.MethodsThis was a prospective, investigator-blinded, randomized controlled trial in which subjects consumed 20% of their daily energy consumption in either almonds or a calorie-matched snack for 16 weeks. This study was completed at the UC Davis Dermatology clinic. Participants were a volunteer sample of generally healthy postmenopausal females with Fitzpatrick skin types 1 and 2. A facial photograph and image analysis system was used to obtain standardized photographs and information on wrinkle width and severity at 0, 8, and 16 weeks. Measurements of transepidermal water loss and sebum production were also completed at 0, 8, and 16 weeks.ResultsFifty healthy postmenopausal females were recruited, 31 participants were enrolled, and 28 completed the study. Under photographic analysis, the almond group had significantly decreased wrinkle severity and width compared with the control group at 16 weeks (p &lt; .02). Changes in skin barrier function were nonsignificant, measured by the transepidermal water loss (p = .65) between the almond and control groups relative to baseline after 16 weeks. No adverse effects were reported.ConclusionOur study demonstrates that daily almond consumption may reduce wrinkle severity in postmenopausal females to potentially have natural antiaging benefits

Silicon-mediated mitigation of wounding stress acts by up-regulating the rice antioxidant system

Silicon (Si) is essential for normal growth and development in plants and is also beneficial for their responses to wounding. However, the mechanisms by which Si acts to mitigate the effects of wounding is not fully understood. This effect possibly occurs through a reduction in the oxidative stresses associated with wounding. Here, we tested this possibility by investigating the effects of applying different concentrations of Si (0,5 and 1,0 mM) to rice plants under wounding stress for a period of 6 and 12 h. We found that a higher uptake of Si was signifiacntly associated with an increase in leaf chlorophyll contet. In response to wounding induced oxidative stress, the extent of lipid bilayer peroxidation was reduced in a dose-dependent manner by Si application for 6 or 12 h. Activity of the catalase enzyme was initially lowered by Si treatment; however, at 1.0 mM Si, catalase activity increased significantly after 12h of wounding stress. A similar response was also observed for a peroxidase enzyme. Polyphenol oxidase showed a significant reduction in activity. We conclude that Si application does not only improve leaf chlorophyll content but can also overcome the oxidative stress due wounds or physical injuries