VisIVOWeb: A WWW Environment for Large-Scale Astrophysical Visualization

This article presents a newly developed Web portal called VisIVOWeb that aims to provide the astrophysical community with powerful visualization tools for large-scale data sets in the context of Web 2.0. VisIVOWeb can effectively handle modern numerical simulations and real-world observations. Our open-source software is based on established visualization toolkits offering high-quality rendering algorithms. The underlying data management is discussed with the supported visualization interfaces and movie-making functionality. We introduce VisIVOWeb Network, a robust network of customized Web portals for visual discovery, and VisIVOWeb Connect, a lightweight and efficient solution for seamlessly connecting to existing astrophysical archives. A significant effort has been devoted for ensuring interoperability with existing tools by adhering to IVOA standards. We conclude with a summary of our work and a discussion on future developments

A Systematic Search for High Surface Brightness Giant Arcs in a Sloan Digital Sky Survey Cluster Sample

We present the results of a search for gravitationally-lensed giant arcs conducted on a sample of 825 SDSS galaxy clusters. Both a visual inspection of the images and an automated search were performed and no arcs were found. This result is used to set an upper limit on the arc probability per cluster. We present selection functions for our survey, in the form of arc detection efficiency curves plotted as functions of arc parameters, both for the visual inspection and the automated search. The selection function is such that we are sensitive only to long, high surface brightness arcs with g-band surface brightness mu_g 10. Our upper limits on the arc probability are compatible with previous arc searches. Lastly, we report on a serendipitous discovery of a giant arc in the SDSS data, known inside the SDSS Collaboration as Hall's arc.Comment: 34 pages,8 Fig. Accepted ApJ:Jan-200

Freeze-Dried Ham Promotes Azoxymethane-Induced Mucin-Depleted Foci and Aberrant Crypt Foci in Rat Colon

Processed and red meat consumption is associated with the risk of colorectal cancer. Meta-analyses have suggested that the risk associated with processed meat is higher. Most processed meats are cured and cooked, which leads to formation of free nitrosyl heme. We speculated that free nitrosyl heme is more toxic than native myoglobin. The promoting effect of a freeze-dried, cooked, cured ham diet was looked for in a 100-day study. Colon carcinogenesis endpoints were aberrant crypt foci and mucin depleted foci (MDF). A second study (14 days) was designed 1) to compare the effect of ham, hemoglobin, and hemin; and 2) to test the effect of sodium chloride, nitrite, and phosphate in diet on early biomarkers associated with heme-induced promotion. In the 100-day study, control and ham-fed rats had 3.5 and 8.5 MDF/colon, respectively (P < 0.0001). Promotion was associated with cytotoxicity and lipid peroxidation. In the short-term study, cytotoxicity and lipid peroxidation of fecal water, and the urinary marker of lipid peroxidation, increased dramatically in ham- and hemin-fed rat. In contrast, the hemoglobin diet, sodium chloride, nitrite, phosphate diet had no effect. Freeze-dried cooked ham can promote colon carcinogenesis in a rodent model. Hemin, but not hemoglobin, mimicked ham effect on early biochemical markers associated with carcinogenesis

Measurement of a reaction-diffusion crossover in exciton-exciton recombination inside carbon nanotubes using femtosecond optical absorption

Exciton-exciton recombination in isolated semiconducting single-walled carbon nanotubes was studied using femtosecond transient absorption. Under sufficient excitation to saturate the optical absorption, we observed an abrupt transition between reaction- and diffusion- limited kinetics, arising from reactions between incoherent localized excitons with a finite probability of ~ 0.2 per encounter. This represents the first experimental observation of a crossover between classical and critical kinetics in a 1D coalescing random walk, which is a paradigm for the study of non- equilibrium systems.Comment: Accepted for Physical Review Letters. Title changed, and "exciton fusion" replaced by "exciton-exciton recombination". Present address of Prof Tom Brown added. 12 pages plus 3 figure

A Magellan-IMACS-IFU Search for Dynamical Drivers of Nuclear Activity. I. Reduction Pipeline and Galaxy Catalog

Using the Inamori Magellan Areal Camera and Spectrograph (IMACS) integral-field unit (IFU) on the 6.5m Magellan telescope, we have designed the first statistically significant investigation of the two-dimensional distribution and kinematics of ionized gas and stars in the central kiloparsec regions of a well-matched sample of Seyfert and inactive control galaxies selected from the Sloan Digital Sky Survey. The goals of the project are to use the fine spatial sampling (0.2 arcsec/pixel) and large wavelength coverage (4000-7000A) of the IMACS-IFU to search for dynamical triggers of nuclear activity in the central region where active galactic nucleus (AGN) activity and dynamical timescales become comparable, to identify and assess the impact of AGN-driven outflows on the host galaxy and to provide a definitive sample of local galaxy kinematics for comparison with future three-dimensional kinematic studies of high-redshift systems. In this paper, we provide the first detailed description of the procedure to reduce and calibrate data from the IMACS-IFU in `long mode' to obtain two-dimensional maps of the distribution and kinematics of ionized gas and stars. The sample selection criteria are presented, observing strategy described and resulting maps of the sample galaxies presented along with a description of the observed properties of each galaxy and the overall observed properties of the sample.Comment: 62 pages. 41 figures. 5 tables. Accepted for publication in ApJS. High-resolution version available at: http://www.astro.ljmu.ac.uk/~pbw/IMACS-IFU/IMACS-1-highRes.pd

High temperature drives topoisomerase mediated chromosomal break repair pathway choice

Cancer-causing mutations often arise from inappropriate DNA repair, yet acute exposure to DNA damage is widely used to treat cancer. The challenge remains in how to specifically induce excessive DNA damage in cancer cells while minimizing the undesirable effects of genomic instability in noncancerous cells. One approach is the acute exposure to hyperthermia, which suppresses DNA repair and synergizes with radiotherapy and chemotherapy. An exception, however, is the protective effect of hyperthermia on topoisomerase targeting therapeutics. The molecular explanation for this conundrum remains unclear. Here, we show that hyperthermia suppresses the level of topoisomerase mediated single- and double-strand breaks induced by exposure to topoisomerase poisons. We further uncover that, hyperthermia suppresses hallmarks of genomic instability induced by topoisomerase targeting therapeutics by inhibiting nuclease activities, thereby channeling repair to error-free pathways driven by tyrosyl-DNA phosphodiesterases. These findings provide an explanation for the protective effect of hyperthermia from topoisomerase-induced DNA damage and may help to explain the inverse relationship between cancer incidence and temperature. They also pave the way for the use of controlled heat as a therapeutic adjunct to topoisomerase targeting therapeutics

High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice.

YesCancer-causing mutations often arise from inappropriate DNA repair, yet acute exposure to DNA damage is widely used to treat cancer. The challenge remains in how to specifically induce excessive DNA damage in cancer cells while minimizing the undesirable effects of genomic instability in noncancerous cells. One approach is the acute exposure to hyperthermia, which suppresses DNA repair and synergizes with radiotherapy and chemotherapy. An exception, however, is the protective effect of hyperthermia on topoisomerase targeting therapeutics. The molecular explanation for this conundrum remains unclear. Here, we show that hyperthermia suppresses the level of topoisomerase mediated single- and double-strand breaks induced by exposure to topoisomerase poisons. We further uncover that, hyperthermia suppresses hallmarks of genomic instability induced by topoisomerase targeting therapeutics by inhibiting nuclease activities, thereby channeling repair to error-free pathways driven by tyrosyl-DNA phosphodiesterases. These findings provide an explanation for the protective effect of hyperthermia from topoisomerase-induced DNA damage and may help to explain the inverse relationship between cancer incidence and temperature. They also pave the way for the use of controlled heat as a therapeutic adjunct to topoisomerase targeting therapeutics

Merging Galaxies in the SDSS EDR

We present a new catalog of merging galaxies obtained through an automated systematic search routine. The 1479 new pairs of merging galaxies were found in approximately 462 sq deg of the Sloan Digital Sky Survey Early Data Release (SDSS EDR; Stoughton et al. 2002) photometric data, and the pair catalog is complete for galaxies in the magnitude range 16.0 <= g* <= 20. The selection algorithm, implementing a variation on the original Karachentsev (1972) criteria, proved to be very efficient and fast. Merging galaxies were selected such that the inter-galaxy separations were less than the sum of the component galaxies' radii. We discuss the characteristics of the sample in terms of completeness, pair separation, and the Holmberg effect. We also present an online atlas of images for the SDSS EDR pairs obtained using the corrected frames from the SDSS EDR database. The atlas images also include the relevant data for each pair member. This catalog will be useful for conducting studies of the general characteristics of merging galaxies, their environments, and their component galaxies. The redshifts for a subset of the interacting and merging galaxies and the distribution of angular sizes for these systems indicate the SDSS provides a much deeper sample than almost any other wide-area catalog to date.Comment: 58 pages, which includes 15 figures and 6 tables. Figures 2, 8, 9, 10, 11, 13, and 14 are provided as JPEG files. For online atlas, see http://home.fnal.gov/~sallam/MergePair/ . Accepted for publication in A

LBT and Spitzer Spectroscopy of Star-Forming Galaxies at 1 < z < 3: Extinction and Star Formation Rate Indicators

We present spectroscopic observations in the rest-frame optical and near- to mid-infrared wavelengths of four gravitationally lensed infrared (IR) luminous star-forming galaxies at redshift 1 < z < 3 from the LUCIFER instrument on the Large Binocular Telescope and the Infrared Spectrograph on Spitzer. The sample was selected to represent pure, actively star-forming systems, absent of active galactic nuclei. The large lensing magnifications result in high signal-to-noise spectra that can probe faint IR recombination lines, including Pa-alpha and Br-alpha at high redshifts. The sample was augmented by three lensed galaxies with similar suites of unpublished data and observations from the literature, resulting in the final sample of seven galaxies. We use the IR recombination lines in conjunction with H-alpha observations to probe the extinction, Av, of these systems, as well as testing star formation rate (SFR) indicators against the SFR measured by fitting spectral energy distributions to far-IR photometry. Our galaxies occupy a range of Av from ~0 to 5.9 mag, larger than previously known for a similar range of IR luminosities at these redshifts. Thus, estimates of SFR even at z ~ 2 must take careful count of extinction in the most IR luminous galaxies. We also measure extinction by comparing SFR estimates from optical emission lines with those from far-IR measurements. The comparison of results from these two independent methods indicates a large variety of dust distribution scenarios at 1 < z < 3. Without correcting for dust extinction, the H-alpha SFR indicator underestimates the SFR; the size of the necessary correction depends on the IR luminosity and dust distribution scenario. Individual SFR estimates based on the 6.2 micron PAH emission line luminosity do not show a systematic discrepancy with extinction, although a considerable, ~0.2 dex scatter is observed.Comment: Accepted for publication in The Astrophysical Journal; 14 pages, 8 figure

Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population

In the current model of early Solar System evolution, the stable members of the Jovian and Neptunian Trojan populations were captured into resonance from the leftover reservoir of planetesimals during the outward migration of the giant planets. As a result, both Jovian and Neptunian Trojans share a common origin with the primordial disk population, whose other surviving members constitute today's trans-Neptunian object (TNO) populations. The cold classical TNOs are ultra-red, while the dynamically excited "hot" population of TNOs contains a mixture of ultra-red and blue objects. In contrast, Jovian and Neptunian Trojans are observed to be blue. While the absence of ultra-red Jovian Trojans can be readily explained by the sublimation of volatile material from their surfaces due to the high flux of solar radiation at 5AU, the lack of ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation models. In this work we report the discovery by the Dark Energy Survey (DES) of two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both with inclinations i >30 degrees, making them the highest-inclination known stable Neptunian Trojans. We have measured the colors of these and three other dynamically stable Neptunian Trojans previously observed by DES, and find that 2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such, 2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using a simulation of the DES TNO detection efficiency, we find that there are 162 +/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based on this result, we discuss the possible origin of the ultra-red Neptunian Trojan population and its implications for the formation history of Neptunian Trojans