WALNUT PEDUNCULAGIN A PROBABLE SERM FOR BREAST CANCER TREATMENT

Walnuts constituents have been actively used in nutrition in slowing cancer growth by its anti-proliferative and anti-angiogenic mechanisms. Pedunculagin, a natural chemical constituent of walnut were performed to check for its binding with Estrogen Receptor (ER) receptor using Insilco approach. Most of current approach towards breast cancer therapies is aimed at blocking ER signaling pathway using various estrogen antagonists like synthetic estrogen receptor modulators (SERMs) which down regulates the signaling cascade leading to tumor activity. This study is aimed to find the binding interactions between Pedunculagin and ER. Pedunculagin structure was extracted from CHEMSPIDER database and Estrogen Receptor (ER) 1QKN was selected, further ligand and receptor structures were minimized with steepest descent and conjugate gradient with minimized energy levels were found to be -14211.04235 Kcal/mol for ligand molecule and -12518.66882 Kcal/mol for ER. Six interacting binding sites were identified between ligand and ER and docking studies showed second active binding site of receptor showed strong affinity and interacting groups. Pedunculagin may act as SERM in modulating the ER signaling activity and may be a probable therapeutic molecule for treating breast cancer

Is emergency cesarean section more risky than elective cesarean section in women with previous cesarean section?

Background: Cesarean section is one of the most performed surgical procedures all over the world, but unfortunately cesarean sections are associated with a great deal of maternal morbidity and mortality. In the past the rate of cesarean section has increased for many avoidable and unavoidable indications both in developed and developing countries. The objective of this study was to compare maternal morbidity and mortality in elective repeat cesarean section (El-RCS) and emergency repeat cesarean section Em-RCS.Methods: Prospective data was recorded on management practices, associated complications and morbidity and mortality on 15664 consecutive cases of previous cesarean section reporting at 30 medical colleges/teaching hospitals for delivery.Results: Of the 15664 women with a previous cesarean section, 5399 (34.5%) women underwent elective repeat cesarean section, 7752 (49.5%) women who underwent emergency repeat cesarean section and 2513 (16.0%) had successful trial of labor (S-TOL). There was    failed trial of labor (F-TOL) in 1522 cases and requiring an emergency cesarean section for delivery of baby. Therefore, total no. of 7752 women had an emergency cesarean section. The overall maternal morbidity was 22.5%, 20.7% in Em-RCS and El-RCS respectively. Blood loss was more than 1000ml in 7.2% of Em-RCS where as in El-RCS it was 8.8%, blood transfusion was 7.5% in Em-RCS where as it was 6.5% in El-RCS, dehiscence of scar in Em-RCS was 4.7% as compared to 2.2% in El-RCS, uterine rupture was 1.2% in Em-RCS as compared to 0.7 % in El-RCS found statistically significant. Post-operative complication was 5.9% cases in Em-RCS where as in El-RCS was 5.8% (p=0.79 non-significant). Maternal mortality was reported in 12 (0.2%) cases of Em-RCS as compared to 5 (0.1%) cases in El-RCS (p=0.37) which was not statistically significant.  Conclusions: Maternal morbidity was found more in emergency repeat cesarean section than in elective repeat cesarean section. Complications and referral of women who are likely to undergo cesarean section should be diagnosed at an early stage so that the maternal   morbidity and mortality can be prevented.

Trail of labor versus elective repeat cesarean section: a comparison of morbidity and mortality at tertiary care teaching hospitals in India

Background: As cesarean birth rates continue to rise, more women are faced with the choice of planning a vaginal delivery or a repeat cesarean section after a previous cesarean section. The objective of this prospective study was to study the morbidities and mortality of women attempting a trial of labor after cesarean (TOLAC) versus elective repeat cesarean section (El-RCS).Methods: Prospective data was recorded on management practices, associated complications and morbidity & mortality for a period of 8 months on 15664 consecutive cases of previous cesarean section reporting at 30 medical colleges/ teaching hospitals for delivery.Results: A trial of labor was planned in 25.8% (4035) women and 34.5% (5399) women underwent elective repeat cesarean section and rest had emergency repeat cesarean section. Overall maternal morbidity due to any cause was 20.7% among El-RCS as compared to 14.2% in TOLAC which was statistically significant (OR: 1.57, CI: 1.41-1.76, P=0.00). Blood loss of more than 1000ml was around 8.0% among TOLAC where as in El-RCS it was 8.8% (OR: 0.89, CI: 0.77-1.94, p=0.14 not statistically significant). Blood transfusion was given in 3.7% in TOLAC where as in El-RCS it was given in 6.5% (OR: 0.56, CI: 0.45-0.68, p=0.00 highly significant).  Complication like dehiscence of scar was similar in both groups. Post-operative complication were seen in 2.8% cases in TOLAC where as in El-RCS it was 5.8% (OR: 0.47, CI: 0.38-0.59, p=0.00 highly significant). Uterine rupture was 0.3% in TOLAC where as in El-RCS it was 0.7% (OR: 0.43, CI: 0.21-0.87, p=0.009 statistically significant). Maternal mortality was reported in 0.2% cases of TOLAC as compared to 0.1% cases in El-RCS (p=0.17) which was not statistically significant.Conclusions: Maternal morbidity was found to be more in elective repeat cesarean section than trial of labor after cesarean section

Is emergency cesarean section more risky than elective cesarean section in women with previous cesarean section?

Background: Cesarean section is one of the most performed surgical procedures all over the world, but unfortunately cesarean sections are associated with a great deal of maternal morbidity and mortality. In the past the rate of cesarean section has increased for many avoidable and unavoidable indications both in developed and developing countries. The objective of this study was to compare maternal morbidity and mortality in elective repeat cesarean section (El-RCS) and emergency repeat cesarean section Em-RCS.Methods: Prospective data was recorded on management practices, associated complications and morbidity and mortality on 15664 consecutive cases of previous cesarean section reporting at 30 medical colleges/teaching hospitals for delivery.Results: Of the 15664 women with a previous cesarean section, 5399 (34.5%) women underwent elective repeat cesarean section, 7752 (49.5%) women who underwent emergency repeat cesarean section and 2513 (16.0%) had successful trial of labor (S-TOL). There was    failed trial of labor (F-TOL) in 1522 cases and requiring an emergency cesarean section for delivery of baby. Therefore, total no. of 7752 women had an emergency cesarean section. The overall maternal morbidity was 22.5%, 20.7% in Em-RCS and El-RCS respectively. Blood loss was more than 1000ml in 7.2% of Em-RCS where as in El-RCS it was 8.8%, blood transfusion was 7.5% in Em-RCS where as it was 6.5% in El-RCS, dehiscence of scar in Em-RCS was 4.7% as compared to 2.2% in El-RCS, uterine rupture was 1.2% in Em-RCS as compared to 0.7 % in El-RCS found statistically significant. Post-operative complication was 5.9% cases in Em-RCS where as in El-RCS was 5.8% (p=0.79 non-significant). Maternal mortality was reported in 12 (0.2%) cases of Em-RCS as compared to 5 (0.1%) cases in El-RCS (p=0.37) which was not statistically significant.  Conclusions: Maternal morbidity was found more in emergency repeat cesarean section than in elective repeat cesarean section. Complications and referral of women who are likely to undergo cesarean section should be diagnosed at an early stage so that the maternal   morbidity and mortality can be prevented.

INTERNATIONAL JOURNAL OF FOOD AND NUTRITIONAL SCIENCES IMPACT FACTOR ~ 1.021 Official Journal of IIFANS INTERNATIONAL JOURNAL OF FOOD AND NUTRITIONAL SCIENCES DIETARY EXPOSURE TO PESTICIDE RESIDUES BY VARIOUS PHYSIOLOGICAL GROUPS OF POPULATION IN ANDHRA P

ABSTRACT Dietary exposure assessment of fifteen pesticide residues was done in Andhra Pradesh. Twelve commonly consumed foods including water, which were representative of the diet, were collected, processed as table ready and analysed for the presence of various Organochlorines, organophosphates and synthetic pyrethroids. All the samples were contaminated with one or more of the 15 pesticide residues and all of them were within the MRLs. DDT and its isomers, Chlorpyriphos and Cypermethrin were frequently detected in many of the food samples. The mean concentration of the pesticide residues ranged from 0.02 µg kg -1 to 5.1 µg kg -1 (fresh weight) in the analysed foods. When exposure assessments was carried out for different age, sex and physiological groups it was found that the estimates of daily dietary intakes of the analysed pesticide residues in the present study are much lower than the volative levels in all age groups that were computed

Biochemical alterations of certain health parameters in cotton growing farmers exposed to organophosphorous and pyrethroid insecticides

A study was carried out on cotton growing farmers to assess the impact of organophosphorous pesticides on the biochemical parameters. Three hundred occupationally exposed farmers to pesticide application and equal number of unexposed subjects were selected from 24 randomly selected villages using stratified proportionate random sampling procedure. Multivariate logistic regression analysis was performed to assess the effect of pesticides on acetyl cholinesterase enzyme activity (AchE), in exposed and unexposed subjects. About 80% of exposed subjects used mixture of organophosphates and were exposed to pesticides for a period of 16.3 years at an average of 4 months / year. The severity of symptoms in the exposed subjects was higher in the second tertile (between 12 and 20 years) than in the third tertile (> 20 years). However, inhibition of AchE activity was significantly high (P < 0.05) in third tertile than the first (< 12 years) and second tertiles. Overall, there was a significant decrease in AchE activity and antioxidants with increased levels of lipid peroxidation (P < 0.01) in exposed subjects than unexposed subjects. The elevated levels of aspartate aminotransferase (AST) and creatinine in the exposed subjects were very marginal and just above the normal values.Key words: Chronic exposure, pesticides, AchE activity, lipid peroxidation

Assessment of effectiveness of targeted intervention program under national AIDS control program among injecting drug users across India

Background: High HIV prevalence among injecting drug users (IDUs) remains a cause of concern and are considered key drivers of concentrated epidemic in India. The present paper aims to assess the effectiveness of the targeted intervention (TI) program on the risk behaviors among IDUs across regions of India. Materials and Methods: This paper used the data from the integrated biological and behavioral surveillance 2014–2015 among the IDUs in India. Descriptive statistics and propensity score matching analysis was carried out to understand the effectiveness of the TI program on the new needle/syringe used and needle/syringe shared in the last injecting episode by accounting for the covariates. Results: The matched samples estimate, i.e., average treatment effect on treated of new needles/syringe used and shared in the last injecting episode by those who received needles/syringes from peer educator or outreach workers (PE/ORWs) and those who did not receive was 2.8% (confidence interval [CI]: 0.05–5.6) increase in the use of new needles/syringes and 6.5% (CI: −9.7–−3.3) decrease in the needles/syringes shared in last injecting episode indicating that IDUs who received new needles/syringes from PE/ORWs are more likely to use new needle/syringe and less likely to share needle/syringes to those who did not receive needles/syringes. The results vary across the different regions of India. Conclusion: TI program proves to be an effective initiative in the behavior change among IDUs as substantiated by use of new needles/syringes and decreased sharing of needles/syringes. TI program coverage varies from region to region and may further be expanded to accelerate the program services to prevent HIV/AIDS

Sample distribution of women with birth during five years preceding the survey, National Family Health Survey (NFHS) 2015–16, India.

Sample distribution of women with birth during five years preceding the survey, National Family Health Survey (NFHS) 2015–16, India.</p