In-Situ Particle Acceleration in Extragalactic Radio Hot Spots: Observations Meet Expectations

We discuss, in terms of particle acceleration, the results from optical VLT observations of hot spots associated with radio galaxies. On the basis of observational and theoretical grounds, it is shown that: 1. relatively low radio-radio power hot spots are the optimum candidates for being detected at optical waves. This is supported by an unprecedented optical detection rate of 70% out of a sample of low radio power hot spots. 2. the shape of the synchrotron spectrum of hot spots is mainly determined by the strength of the magnetic field in the region. In particular, the break frequency, related to the age of the oldest electrons in the hot spots, is found to increase with decreasing synchrotron power and magnetic field strength. Both observational results are in agreement with an in-situ particle acceleration scenario.Comment: 5 pages, TeX (or Latex, etc), 4 figures, to appear in MNRAS Letter, Updated reference

Bad moon on the rise? Lunar cycles and incidents of crime

Popular cultures in Western societies have long espoused the notion that phases of the moon influence human behavior. In particular, there is a common belief the full moon increases incidents of aberrant, deviant, and criminal behavior. Using police, astronomical, and weather data from a major southwestern American city, this study assessed whether lunar cycles related with rates of reported crime. The findings fail to support popular lore, which has suggested that lunar phase influenced the volume of crime reported to the police. Future research directions examining qualitative rather than quantitative aspects of this problem may yield further inform the understanding of whether lunar cycles appreciably influence demands for policing services

A Tale of Three Cities: Crime and Displacement after Hurricane Katrina

When Hurricane Katrina struck New Orleans in August 2005, it greatly disrupted both the physical and social structures of that community. One consequence of the hurricane was the displacement of large numbers of New Orleans residents to other cities, including Houston, San Antonio, and Phoenix. There has been media speculation that such a grand-scale population displacement led to increased crime in communities that were recipient of large numbers of displaced New Orleans residents. This study was a case study of three cities with somewhat different experiences with Katrina\u27s diaspora. Time series analysis was used to examine the pre- and post-Katrina trends in six Part I offenses (murder, robbery, aggravated assault, rape, burglary, and auto theft) to assess any impact of such large-scale population shifts on crime in host communities. Contrary to much popular speculation, only modest effects were found on crime. Social disorganization theory was used to frame both the analysis and the interpretation of these result

Diabetic retinopathy, diabetic macular edema, and cardiovascular risk: the importance of a long-term perspective and a multidisciplinary approach to optimal intravitreal therapy

Diabetic retinopathy (DR), diabetic macular edema (DME), and cardiovascular disease (CVD) resulting from vascular damage from persistently elevated blood glucose levels are among the serious secondary pathologies associated with long-standing diabetes mellitus. The established link between DR and CVD suggests the need for appropriate and early management of patients with diabetes to minimize CV risk. This is of particular importance in patients with recent, or a history of, major CV events. Early management of DR is a complex task that requires comprehensive evaluation and a multidisciplinary approach to manage complications, risk factors, and interactions between different aspects of the disease. Anti-vascular endothelial growth factor (VEGF) agents have become an important therapeutic modality in ophthalmology. However, their use is contraindicated in patients with DR and/or DME with a CV event in the previous 3 months. In patients with DME, corticosteroids target the multifaceted inflammatory pathways involved in the pathogenesis of DR, with a broader spectrum of action than anti-VEGF agents. In this context, recent guidelines suggest the use of corticosteroids, and in particular dexamethasone intravitreal implant, as a well-tolerated and efficacious first-line treatment in patients with high CV risk, such as a history of or recent major CV events. This review focuses on the subset of diabetic patients with a prior CV event, DR, and DME and discusses the need for a holistic approach in evaluating the optimal therapeutic choice for the care of the individual patient, supported by real-world clinical experience on long-term dexamethasone intravitreal implant therapy

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment

microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression. MiRNAs are involved in the control of a multiplicity of biological processes, and their absence or altered expression has been associated with a variety of human diseases, including cancer. Recently, extracellular miRNAs (ECmiRNAs) have been described as mediators of intercellular communication in multiple contexts, including tumor microenvironment. Cancer cells cooperate with stromal cells and elements of the extracellular matrix (ECM) to establish a comfortable niche to grow, to evade the immune system, and to expand. Within the tumor microenvironment, cells release ECmiRNAs and other factors in order to influence and hijack the physiological processes of surrounding cells, fostering tumor progression. Here, we discuss the role of miRNAs in the pathogenesis of multicomplex diseases, such as Alzheimer's disease, obesity, and cancer, focusing on the contribution of both intracellular miRNAs, and of released ECmiRNAs in the establishment and development of cancer niche. We also review growing evidence suggesting the use of miRNAs as novel targets or potential tools for therapeutic applications

Chandra detection of the radio and optical double hot spot of 3C 351

In this letter we report a Chandra X-ray detection of the double northern hot spot of the radio quasar 3C 351. The hot spot has also been observed in the optical with the Hubble Space Telescope (R-band) and with the 3.5m. Telescopio Nazionale Galileo (B-band). The radio-to-optical and X-ray spectra are interpreted as the results of the synchrotron and synchrotron-self-Compton (SSC) mechanisms, respectively, with hot-spot magnetic field strengths ~3 times smaller than the equipartition values. In the framework of shock acceleration theory, we show that the requirement for such a relatively small field strength is in agreement with the fitted synchrotron spectral models and with the sizes of the hot spots. Finally, we show that the combination of a lower magnetic field strength with the high frequencies of the synchrotron cut-off in the fitted synchrotron spectra provides strong evidence for electron acceleration in the hot spots.Comment: 16 pag. + 2 .PS figures (fig.2 color), ApJ Letter in pres

Development of the opto-mechanical design for ICE-T

ICE-T (International Concordia Explorer Telescope) is a double 60 cm f/1.1 photometric robotic telescope, on a parallactic mount, which will operate at Dome C, in the long Antarctic night, aiming to investigate exoplanets and activity of the hosting stars. Antarctic Plateau site is well known to be one of the best in the world for observations because of sky transparency in all wavelengths and low scintillation noise. Due to the extremely harsh environmental conditions (the lowest average temperature is -80$^\circ$C) the criteria adopted for an optimal design are really challenging. Here we present the strategies we have adopted so far to fulfill the mechanical and optical requirements.Comment: 7 pages, 2 figures, contributed talk at 'An astronomical Observatory at Concordia (Dome C, Antarctica) for the next decade', 11-15 May, Rome (Italy

Speech-driven facial animations improve speech-in-noise comprehension of humans

Understanding speech becomes a demanding task when the environment is noisy. Comprehension of speech in noise can be substantially improved by looking at the speaker’s face, and this audiovisual benefit is even more pronounced in people with hearing impairment. Recent advances in AI have allowed to synthesize photorealistic talking faces from a speech recording and a still image of a person’s face in an end-to-end manner. However, it has remained unknown whether such facial animations improve speech-in-noise comprehension. Here we consider facial animations produced by a recently introduced generative adversarial network (GAN), and show that humans cannot distinguish between the synthesized and the natural videos. Importantly, we then show that the end-to-end synthesized videos significantly aid humans in understanding speech in noise, although the natural facial motions yield a yet higher audiovisual benefit. We further find that an audiovisual speech recognizer (AVSR) benefits from the synthesized facial animations as well. Our results suggest that synthesizing facial motions from speech can be used to aid speech comprehension in difficult listening environments