13 research outputs found
Precursor synthesis, radiosynthesis and in vivo evaluation in mice of [I-123]-(4-fluorophenyl) {1-[2-(2-iodophenyl)ethyl]piperidin-4-yl}-methanone and -methanol, as potential SPECT tracers for the 5-HT2A-receptor
No full textSynthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography.
No full textAcetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clearance of the tracer from the blood and a uniform distribution in the different brain regions. Unfortunately, the poor passage through the blood brain barrier makes the tracer not suitable for PET studies
Synthesis and in vivo evaluation of [123I]-pyrimidine-Org 13063 as potential SPECT radioligand for the 5-HT1A receptor
No full textHigh performance liquid chromatographic determination of 123-I labeled tamoxifen metabolites in human plasma.
No full textSynthesis and Preliminary in vivo Evaluation of 4-[123I]iodo-N-{2-[4-(6-trifluoromethylpyridin- 2-yl)-piperazin-1-yl]ethyl}benzamide, a potential SPECT radioligand for the 5- HT1a receptor.
No full textTitle: Synthesis, biodistribution and blocking studies in mice of a new 123I-labeled dopamine D3 antagonist Dierckx RA, Slegers G
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FANC-survey of administered activity and determination of Belgian diagnostic reference levels for radiopharmaceuticals in daily practice
No full textIn vivo evaluation of 4-[I-123]iodo-N-{2-[4-(6-trifluoromethyl-2-pyridinyl)-1-piperazinyl]ethyl}benzamide, a potential SPECT radioligand for the 5-HT1A receptor.
No full text125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution
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