ГЕНЕРАЛИЗОВАННЫЙ ЭРИТЕМАТОЗНО-УРТИКАРНЫЙ ДЕРМАТИТ И ПОРАЖЕНИЕ РЕСПИРАТОРНОГО ТРАКТА КАК ПРОЯВЛЕНИЕ СОЧЕТАННОЙ ПАРВОВИРУСНОЙ В19 И МИКОПЛАЗМЕННОЙ ИНФЕКЦИИ У РЕБЕНКА 2 ЛЕТ

The article describes the clinical case of combined skin lesions in the form of generalized erythematous-urticarial dermatitis and the respiratory tract in the form of rhinoadenopharyngitis, simple bronchitis, in a child of 2 years. Caused by parvovirus B19 and Мycoplasma pneumoniae. The problems of diagnosis, treatment, variety of clinical manifestations of parvovirus B19 infection and Мycoplasma pneumoniae are discussed.В статье представлено описание клинического случая сочетанного поражения кожных покровов в виде генерализованного эритематозно-уртикарного дерматита и респираторного тракта в виде риноаденофарингита, бронхита, вызванного парвовирусом В19 и микоплазмой (Mycoplasma pneumoniaе) у ребенка 2 лет. Обсуждаются вопросы диагностики, лечения, многообразия клинических проявлений инфицирования парвовирусом В19 и Mycoplasma pneumoniaе

Vitamin D status in children aged 0 to 3 years living in Moscow. Treatment and prevention of vitamin D deficiency

The aim of this paper was to assess vitamin D status in infants and young children in Moscow. 211 children aged 0 to 3 years were examined, of which 103 (48.8%) were under the age of 12 months, 64 (30.3%) children were 2 years old, 44 (20.9%) were 3 years old. The number of boys and girls was almost equal (52.6 and 47.4%). In the examined group of children, only 38.4% had the serum calcidiol level within the normal range (> 30 ng/ml). In other cases (61.6%), the children were diagnosed with one or another degree of vitamin D deficiency: severe deficiency in 2.4%; deficiency in 27.5%; insufficiency in 31.8% of patients. The frequency of registration of vitamin D insufficiency or deficiency increases significantly with the increase of years (R = -0.22, p = 0.0018). When comparing the obtained data with the results of study RODNICHOK, it was found that the vitamin D deficiency value in Moscow children was significantly lower than that in the regions located to the south (Kazan 65.0%; p <0.01; Stavropol 45 , 8%; p <0.05), and the Far East (Blagoveshchensk 42.6%; p <0.05; Khabarovsk 42.9%; p <0.05; Vladivostok 72.7%; p < 0.01). The absolute majority of the examined children (84.8%) received a prophylactic dose of vitamin D of 500 to 1500 IU/day. The 500 IU/day dose is insufficient, because 71.2% of patients in this subgroup had a low vitamin D status. A similar effect was obtained in patients taking vitamin D at a dose of 1000 and 1500 IU/day: the absolute values of cholecalciferol reliably increased by 1.8 and 1.9 times, the number of patients with normal vitamin values increased by 2.7 and 2.2 times as compared with intake of vitamin D at a dose of 500 IU; the deficiency level reduced by more than 8 times as compared to the control group and more than 2 times as compared to the patients receiving 500 IU. The seasonal factor does not have a significant effect on the serum calcidiol level (r = 0.06 at p = 0.3), which may be due to the peculiarities of the specific prevention of hypovitaminosis: a bit more than a third of children take vitamin D in summer (39.2%), whereas absolute majority (83.3%) take it in winter

Can the physiological process of teething in babies be abnormal?

The article discusses the problem of teething in babies, the related mechanisms and factors. The research findings demonstrate the importance of different clinical symptoms of teething in infants, the relationship of the process with the baby's body type. Questions of the current therapy of pathological teething are considered

GENERALIZED ERYTHEMATOUS-URTICARIAL DERMATITIS AND RESPIRATORY INFECTIONAS A MANIFESTATION OF COMBINED PARVOVIRUS B19 AND MYCOPLASMA PNEUMONIAE INFECTION IN A 2-YEAR-OLD CHILD

The article describes the clinical case of combined skin lesions in the form of generalized erythematous-urticarial dermatitis and the respiratory tract in the form of rhinoadenopharyngitis, simple bronchitis, in a child of 2 years. Caused by parvovirus B19 and Мycoplasma pneumoniae. The problems of diagnosis, treatment, variety of clinical manifestations of parvovirus B19 infection and Мycoplasma pneumoniae are discussed

EFFICIENCY OF PREVENTION AND MANAGEMENT OF VITAMIN D DEFICIENCY IN YOUNG CHILDREN IN RUSSIA DEPENDING ON THE REGION OF RESIDENCE (BASED ON THE RESULTS OF RODNICHOK-2 STUDY)

Medical examination of 360 children from four regions of Russia (Moscow, Astrakhan, Stavropol, Kazan) showed significant regional differences in the sufficiency and compensation of vitamin D deficiency at the baseline (Day 0) and established factors associated with vitamin D sufficiency on Day 0. The established interregional differences in vitamin D levels were not due to insolation, but primarily to adequate vitamin D supplementation received at the baseline. Vitamin D supplementation (an average of 894 ± 632.6 IU/day) significantly reduced the risk of vitamin D deficiency (RR 0.15, 95% CI 0.09–0.26, P = 5.7 x 10–14). The study included the analysis of factors associated with the increase in 25(OH)D levels during the administration of Aquadetrim, identification of predictors of patient’s response and the analysis of identified predictors. The most important factor determining the patient’s response was the dose of vitamin D taken by the patient: 25(OH)D levels increased by 1 ng/ml with an increase in the dose of vitamin D by 90 IU per day. As can be seen from the above, the study results indicate that the vitamin D deficiency requires a long-term preventive therapy (for at least several months) with adequate doses of vitamin D (1000–2000 IU/day)

ГЕНЕРАЛИЗОВАННЫЙ ЭРИТЕМАТОЗНО-УРТИКАРНЫЙ ДЕРМАТИТ И ПОРАЖЕНИЕ РЕСПИРАТОРНОГО ТРАКТА КАК ПРОЯВЛЕНИЕ СОЧЕТАННОЙ ПАРВОВИРУСНОЙ В19 И МИКОПЛАЗМЕННОЙ ИНФЕКЦИИ У РЕБЕНКА 2 ЛЕТ

The article describes the clinical case of combined skin lesions in the form of generalized erythematous-urticarial dermatitis and the respiratory tract in the form of rhinoadenopharyngitis, simple bronchitis, in a child of 2 years. Caused by parvovirus B19 and Мycoplasma pneumoniae. The problems of diagnosis, treatment, variety of clinical manifestations of parvovirus B19 infection and Мycoplasma pneumoniae are discussed.В статье представлено описание клинического случая сочетанного поражения кожных покровов в виде генерализованного эритематозно-уртикарного дерматита и респираторного тракта в виде риноаденофарингита, бронхита, вызванного парвовирусом В19 и микоплазмой (Mycoplasma pneumoniaе) у ребенка 2 лет. Обсуждаются вопросы диагностики, лечения, многообразия клинических проявлений инфицирования парвовирусом В19 и Mycoplasma pneumoniaе.</p