Historical Review of Ethnopharmacology in Karelia (1850s–2020s): Herbs and healers

Ethnopharmacological relevance: The traditional medicine of various peoples populating Russia is strongly underrepresented in the international anthropological literature. In addition, it has a multicomponent structure, a long history of relations with official medicine, and is still a living system with many people using folk remedies and visiting ritual specialists. Aim of the study: The article is a review of folk medicine in Karelia (north-west part of Russia) providing a short description of the history of medicine in this region and a comparison of folk medicine among Karelians and Russians. Materials and methods: The review analyzes and systematizes published and unpublished sources related to the main remedies used by the local populations – plants, animal products, minerals, etc. – from the 1850s–2000s, tracking the main tendencies in publications about the folk medicine of Karelians and Russians of Karelia. Results: A total of 104 medicinal plants belonging to 46 families were mentioned as medicinal. In total, they represented 386 uses which demonstrate the leading role of plant remedies in the folk medicine of Karelia. The plant species with the most uses were Betula sp., Plantago sp., Rubus idaeus, Viburnum opulus, Vaccinium vitis-idaea, and Daphne mezereum. Medicinal uses of other origins had more modest numbers: animal remedies included 146 uses, and mineral ones 43 uses. Among animal-based remedies, physiological discharges of the human body were the most popular; fish oil and bear body parts were the most used from the wild, while from the household various components of cows, horses, and dogs were used. Animal remedies were mostly used for healing furuncles, scrofula, frostbite, hernia, and lanugo. The most diversely used mineral remedy was salt. Conclusions: Karelians and Russians are very disproportionally represented in the literature due to the lack of interest in the folk medicine of Russians in Karelia, in contrast to that of Karelians. The disparity does not allow adequate comparison, but nonetheless the available data demonstrate that the remedies shared by both ethnic groups are quite few. The review also contributes to research on the relationship of folk medicine and various state institutions in Russia/the Soviet Union

JUSTIFICATION OF THE DIRECTIONS OF DEVELOPMENT OF THE ORGANIZATIONAL AND ECONOMIC MECHANISM OF BUSINESS MANAGEMENT OF MECHANICAL ENGINEERING

The concept and the main directions of methodology of development of the organizational and economic mechanism of business management of mechanical engineering on the basis of reserve and factorial approach is proved. Teoretiko-methodological approaches to ensuring effective functioning and a sustainable development of the enterprise are specified

JUSTIFICATION OF THE DIRECTIONS OF DEVELOPMENT OF THE ORGANIZATIONAL AND ECONOMIC MECHANISM OF BUSINESS MANAGEMENT OF MECHANICAL ENGINEERING

The concept and the main directions of methodology of development of the organizational and economic mechanism of business management of mechanical engineering on the basis of reserve and factorial approach is proved. Teoretiko-methodological approaches to ensuring effective functioning and a sustainable development of the enterprise are specified

Desarrollo de la alfabetización intercultural de los docentes en el sistema de educación vocacional adicional

The general trends of contemporary education include the desire to integrate and universalize social relations. This study aims to explain that the process leads to the intensification of intercultural interaction between representatives of different cultural communities. The expansion of intercultural contacts in the modern world emphasizes the importance of achieving mutual understanding between people of different cultures. The study concludes that multicultural education should become an inseparable part of general education, including additional professional education, since interpersonal relationships take place in a multiethnic and multicultural environment.Las tendencias generales de la educación contemporánea incluyen el deseo de integrar y universalizar las relaciones sociales. Este estudio pretende explicar que el proceso conduce a la intensificación de la interacción intercultural entre representantes de diferentes comunidades culturales. La expansión de los contactos interculturales en el mundo moderno enfatiza la importancia de lograr el entendimiento mutuo entre personas de diferentes culturas. El estudio concluye que la educación multicultural debería convertirse en una parte inseparable de la educación general, incluida la e ucación profesional adicional, ya que las relaciones interpersonales tienen lugar en un entorno multiétnico y multicultural

Coercion, violation of privacy and everyday difficulties as the cause of patient refusal treatment in psychiatric hospitals in Russia

Treatment in a psychiatric hospital is accompanied by a restriction of independence, violation of privacy, coercion, which causes displeasure of patients. The aim of the study was to verify the scale of everyday problems, violations of privacy and coercion in a psychiatric hospital to develop recommendations for the organization of a therapeutic environment. The study included 191 patients in a psychiatric hospital. Anonymous questionnaire was used. Statistical processing of the database was carried out by nonparametric method

Child’s heart development and contractility from prenatal to postnatal period

This literature review analyzes current data on the main stages of child’s heart contractility development from prenatal to postnatal period. The presented information will expand the conventional ideas on the age-related cardiovascular physiology in children, supplementing with relevant knowledge about the patterns of left ventricular mechanics, and the mechanisms affecting child’s heart morphology. In addition, we consider the evolutionary feasibility of the simultaneous existence of various left ventricular mechanics models, which ensure the effective cardiac function in the postnatal period. This is very important for the work of neonatologists, pediatricians, pediatric cardiologists and therapists

Cytokine profile in hospitalized patients with COVID-19 of different severity

Analysis of cytokine profile markers in conjunction with the clinical manifestations of coronavirus disease 2019 (COVID-19) can provide valuable information about the pathogenetic manifestations of the disease, and therefore, in the future, determine drugs that affect the cytokine storm and have an anti-inflammatory effect.Aim. To identify correlations between the parameters of the developed cytokine profile and the clinical course in hospitalized patients with COVID-19 of different severity.Material and methods. The study included 70 hospitalized patients with a confirmed diagnosis of COVID-19, with a mean age of 58 [50;69] years, including 40 men (57%) and 30 women (43%). The average lung involvement according to computed tomography (CT) at admission was CT-2 [1;3]. Peripheral venous blood was taken at admission, which averaged 7 [6; 8] days from the symptom onset. Standard biochemical parameters were studied, as well as 47 cytokines and chemokines using the Multiplex system (Merck KGaA, Darmstadt, Germany).Results. Correlations was found between the lung involvement degree and the level of IL-8 (r=0,31, p<0,05), IL-15 (r=0,35, p<0,05), IL-18 (r=0,31, p<0,05), MCP-1 (r=0,36, p<0,05), MIG (r=0,50, p<0,05), TNF-α (r=0,41, p<0,05). An inverse correlation was also found in the level of blood oxygen saturation with the same indicators as follows: IL-8 (r=-0,27, p<0,05), IL-15 (r=-0,34, p<0,05), IL-18 (r=-0,31, p<0,05), MCP-1 (r=-0,40, p<0,05), MIG (r=-0,56, p<0,05), TNF-α (r=-0,45, p<0,05). IL-6 levels were significantly elevated in patients with severe COVID-19 (CT3, CT4), while no increase in IL-6 was observed in patients with moderate disease (CT1, CT2). It is noteworthy that in patients with diabetes, the highest values of IL-12, IL-9 were recorded.Conclusion. Hyperinflammatory syndrome in severe COVID-19 is manifested by high levels of IL-6, MIG, MDC, MCP-1, M-CSF, TNF-α, β, IL-8, IL-18, IL-15. With the CT-1 and CT-2, an increase in only the level of IL-18, IL-8 is noted. The identified patterns prove and make it possible to explain a number of systemic inflammatory changes that occur with COVID-19

Prevalence and dynamics of depression and anxiety in local and foreign medical students for a 6-year training period

The academic load in medical institutes is 2 times higher than in other universities, and the training itself is emotionally stressful, which affects the students’ health. A continuous sample of 1045 medical students from 1 to 6 year of education was examined: 724 local (Russian) and 321 foreign students (India). Depression was more common among Russian (28.7%) than foreign students (17.8%

Prevalence and dynamics of depression and anxiety in local and foreign medical students for a 6-year training period

The academic load in medical institutes is 2 times higher than in other universities, and the training itself is emotionally stressful, which affects the students' health. A continuous sample of 1045 medical students from 1 to 6 year of education was examine