Growth, profits and technological choice: The case of the Lancashire cotton textile industry

Using Lancashire textile industry company case studies and financial records, mainly from the period just before the First World War, the processes of growth and decline are re-examined. These are considered by reference to the nature of Lancashire entrepreneurship and the impact on technological choice. Capital accumulation, associated wealth distributions and the character of Lancashire business organisation were sybiotically linked to the success of the industry before 1914. However, the legacy of that accumulation in later decades, chronic overcapacity, formed a barrier to reconstruction and enhanced the preciptious decline of a once great industry

Non-perturbative QEG Corrections to the Yang-Mills Beta Function

We discuss the non-perturbative renormalization group evolution of the gauge coupling constant by using a truncated form of the functional flow equation for the effective average action of the Yang-Mills-gravity system. Our result is consistent with the conjecture that Quantum Einstein Gravity (QEG) is asymptotically safe and has a vanishing gauge coupling constant at the non-trivial fixed point.Comment: To appear in the proceedings of CORFU 200

The limits of market-based governance and accountability - PFI refinancing and the resurgence of the regulatory state

The refinancing of PFI (Private Finance Initiative) projects currently represents one of the most contentious aspects of Public Private Partnership in the UK. The negative publicity associated with UK PFI refinancing deals is associated with two main factors, namely evidence of massive private sector profit making in connection with past refinancing deals, and the ‘failure’ of private sector financiers to share refinancing profits with public sector organisations in line with government recommendations. This paper examines the ongoing ‘dance of non-regulation’ associated with PFI refinancing on the basis of traditional Marxist notions of ‘contradictions of capitalism’. Our analysis commences with the argument that PFI represents a prototypical case of an alliance between finance capital and the state, which has been created with the principal purpose of establishing a new source of profits for the private sector. A Marxist analysis of state-business relationships would predict such an alliance to show tendencies towards instability which could arise from a number of factors. These include, among others, the inherent lack of legitimacy of such an alliance vis a vis established policy goals and the stakeholders associated with them; a lack of a credible regulatory framework which, as a systemic prerequisite of private sector profit making, further exacerbates existing problems of legitimation; and, perhaps most importantly, the potentially self-defeating attempt by capital to maximise gains from the exploitation of the existing alliance without concern for the possibility of a political or regulatory backlash. Examining the recent history of PFI refinancing we find evidence of most of these destabilising tendencies which we expect to trigger calls for a greater regulation of PFI projects in the future

The limits of market-based governance and accountability - PFI refinancing and the resurgence of the regulatory state

The refinancing of PFI (Private Finance Initiative) projects currently represents one of the most contentious aspects of Public Private Partnership in the UK. The negative publicity associated with UK PFI refinancing deals is associated with two main factors, namely evidence of massive private sector profit making in connection with past refinancing deals, and the ‘failure’ of private sector financiers to share refinancing profits with public sector organisations in line with government recommendations. This paper examines the ongoing ‘dance of non-regulation’ associated with PFI refinancing on the basis of traditional Marxist notions of ‘contradictions of capitalism’. Our analysis commences with the argument that PFI represents a prototypical case of an alliance between finance capital and the state, which has been created with the principal purpose of establishing a new source of profits for the private sector. A Marxist analysis of state-business relationships would predict such an alliance to show tendencies towards instability which could arise from a number of factors. These include, among others, the inherent lack of legitimacy of such an alliance vis a vis established policy goals and the stakeholders associated with them; a lack of a credible regulatory framework which, as a systemic prerequisite of private sector profit making, further exacerbates existing problems of legitimation; and, perhaps most importantly, the potentially self-defeating attempt by capital to maximise gains from the exploitation of the existing alliance without concern for the possibility of a political or regulatory backlash. Examining the recent history of PFI refinancing we find evidence of most of these destabilising tendencies which we expect to trigger calls for a greater regulation of PFI projects in the future

Analytic continuation of the Hurwitz Zeta Function with physical application

A new formula relating the analytic continuation of the Hurwitz zeta function to the Euler gamma function and a polylogarithmic function is presented. In particular, the values of the first derivative of the real part of the analytic continuation of the Hurwitz zeta function for even negative integers and the imaginary one for odd negative integers are explicitly given. The result can be of interest both on mathematical and physical side, because we are able to apply our new formulas in the context of the Spectral Zeta Function regularization, computing the exact pair production rate per space-time unit of massive Dirac particles interacting with a purely electric background field.Comment: Replaced version, minor changes. 9 pages, to be published in J. Math. Phy

Quantum corrections to Higher-Dimensional Theories

This is a non-technical summary of the subtleties of quantum corrections on extra-dimensional theories: should one first renormalize and then mode expand, or first expand in four-dimensional modes and then renormalize?Comment: 9 pages, based on a talk at IRGAC 2006, Barcelon

Comparison theory and smooth minimal C*-dynamics

We prove that the C*-algebra of a minimal diffeomorphism satisfies Blackadar's Fundamental Comparability Property for positive elements. This leads to the classification, in terms of K-theory and traces, of the isomorphism classes of countably generated Hilbert modules over such algebras, and to a similar classification for the closures of unitary orbits of self-adjoint elements. We also obtain a structure theorem for the Cuntz semigroup in this setting, and prove a conjecture of Blackadar and Handelman: the lower semicontinuous dimension functions are weakly dense in the space of all dimension functions. These results continue to hold in the broader setting of unital simple ASH algebras with slow dimension growth and stable rank one. Our main tool is a sharp bound on the radius of comparison of a recursive subhomogeneous C*-algebra. This is also used to construct uncountably many non-Morita-equivalent simple separable amenable C*-algebras with the same K-theory and tracial state space, providing a C*-algebraic analogue of McDuff's uncountable family of II_1 factors. We prove in passing that the range of the radius of comparison is exhausted by simple C*-algebras.Comment: 30 pages, no figure

The Landscape of Non-Viral Gene Augmentation Strategies for Inherited Retinal Diseases

Inherited retinal diseases (IRDs) are a heterogeneous group of disorders causing progressive loss of vision, affecting approximately one in 1000 people worldwide. Gene augmentation therapy, which typically involves using adeno-associated viral vectors for delivery of healthy gene copies to affected tissues, has shown great promise as a strategy for the treatment of IRDs. However, the use of viruses is associated with several limitations, including harmful immune responses, genome integration, and limited gene carrying capacity. Here, we review the advances in non-viral gene augmentation strategies, such as the use of plasmids with minimal bacterial backbones and scaffold/matrix attachment region (S/MAR) sequences, that have the capability to overcome these weaknesses by accommodating genes of any size and maintaining episomal transgene expression with a lower risk of eliciting an immune response. Low retinal transfection rates remain a limitation, but various strategies, including coupling the DNA with different types of chemical vehicles (nanoparticles) and the use of electrical methods such as iontophoresis and electrotransfection to aid cell entry, have shown promise in preclinical studies. Non-viral gene therapy may offer a safer and effective option for future treatment of IRDs

Usher syndrome: clinical features, molecular genetics and advancing therapeutics

Usher syndrome has three subtypes, each being clinically and genetically heterogeneous characterised by sensorineural hearing loss and retinitis pigmentosa (RP), with or without vestibular dysfunction. It is the most common cause of deaf–blindness worldwide with a prevalence of between 4 and 17 in 100 000. To date, 10 causative genes have been identified for Usher syndrome, with MYO7A accounting for >50% of type 1 and USH2A contributing to approximately 80% of type 2 Usher syndrome. Variants in these genes can also cause non-syndromic RP and deafness. Genotype–phenotype correlations have been described for several of the Usher genes. Hearing loss is managed with hearing aids and cochlear implants, which has made a significant improvement in quality of life for patients. While there is currently no available approved treatment for the RP, various therapeutic strategies are in development or in clinical trials for Usher syndrome, including gene replacement, gene editing, antisense oligonucleotides and small molecule drugs