Presence of macrovolt T wave alternans and short coupled PVC simultaneously in a patient with long QT syndrome

This report presents a patient with macrovolt T wave alternans, PVC with R on T or a long-short sequence followed by torsades de pointes

First report of Dinocampus coccinellae (Hym.: Braconidae) from Iran

در نمونه‌برداری‌هایی که طی شهریور تا آبان ماه 1389 در مزرعه تحقیقاتی دانشگاه بوعلی سینا در دستجرد همدان جهت بررسی میزان پارازیتیسم کفشدوزک Hippodamia variegata (Goeze) (Col.: Coccinellidae) انجام شد، زنبور پارازیتوئید Dinocampus coccinellae (Schrank) جمع‌آوری گردید. این زنبور برای اولین‌بار از ایران گزارش می‌شود

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression

BackgroundDespite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.MethodsIn this study the upregulation of TF release upon activation of various cancer cell lines, and the correlation with TF and PAR2 expression and/or activity was examined. Microvesicle release was induced by PAR2 activation in seventeen cell lines and released microvesicle density, microvesicle-associated TF activity, and phoshpatidylserine-mediated activity were measured. The time-course for TF release was monitored over 90 min in each cell line. In addition, TF mRNA expression, cellular TF protein and cell-surface TF activities were quantified. Moreover, the relative expression of PAR2 mRNA and cellular protein were analysed. Any correlations between the above parameters were examined by determining the Pearson’s correlation coefficients.ResultsTF release as microvesicles peaked between 30–60 min post-activation in the majority of cell lines tested. The magnitude of the maximal TF release positively correlated with TF mRNA (c = 0.717; p

Overexpression of orphan receptor tyrosine kinase Ror1 as a putative tumor-associated antigen in Iranian patients with acute lymphoblastic leukemia

Receptor tyrosine kinases (RTKs) are a group of enzymes involved in a variety of physiological and pathological processes. The human Ror1 is a member of the RTK family with unknown ligand and biological function. Overexpression of Ror1 has recently been reported in B-cell chronic lymphocytic leukemia. The aim of this study was to explore the expression profile of Ror1 in acute lymphoblastic leukemia (ALL) cells. Therefore, leukemic cells were isolated from the bone marrow and/or peripheral blood (PB) of 57 ALL patients. Immunophenotyping was performed by flow cytometry and mRNA expression was detected by RT-PCR. Overexpression of Ror1 mRNA was detected in 23 of 57 (40) ALL patients. A similar expression pattern was observed in ALL cell lines, with 4 of 12 (33) being positive. Stimulation of normal PB mononuclear cells with pokeweed mitogen and phorbol myristate acetate induced substantially higher Ror1 mRNA expression compared to unstimulated cultured cells. There has been neither a significant association between Ror1 expression and the immunophenotypic profile of the leukemic cells, nor with other clinical or hematological features of the patients. In conclusion, our findings propose Ror1 as a new tumor-associated antigen and a potential tool for targeted immunotherapy and monitoring of minimal residual disease in ALL. Copyright © 2008 S. Karger AG

AIDS knowledge and attitudes in a Turkish population: an epidemiological study

BACKGROUND: The aim of this study was to investigate and present some pertinent comments concerning Acquired Immunodeficiency Syndrome (AIDS) knowledge, attitudes and misconceptions among the general population in a city of west Turkey. This study was deemed important and relevant due to the increasing importance of AIDS in Turkey and the other countries. METHODS: Using a multistage area sampling method, a random sample of individuals aged 11–83 years, living in 65 different quarters in the city of Eskisehir, Turkey during September, October and November 2004 were interviewed. RESULTS: In all, 1048 respondents completed the survey. In most items, respondents displayed a fairly good to excellent degree of knowledge about HIV/AIDS. Individuals with higher degrees of education indicated more correct responses in all items relating to knowledge of HIV/AIDS. In general, the respondents' attitudes towards AIDS and people with AIDS were found to be tolerant and positive, with one answer choice showing that the majority of the respondents agreed with the statement that those with HIV/AIDS must be supported, treated and helped (90.7%). Moreover, the proportions of the respondents' misconceptions were found to be significantly low for all the items. However, nearly one fourth of the respondents agreed with the misconceptions 'AIDS is a punishment by God' and 'One is not infected with HIV/AIDS if engaged in sport and well nourished'. CONCLUSION: In general HIV/AIDS related knowledge was high and people showed positive attitudes. However, people continue to hold misconceptions about AIDS and these need to be addressed by health education programs targeting those at higher risk

Interpretation of Fracture Toughness and R-Curve Behavior by Direct Observation of Microfracture Process in Ti-Based Dendrite-Containing Amorphous Alloys

Fracture properties of Ti-based amorphous alloys containing ductile beta dendrites were explained by directly observing microfracture processes. Three Ti-based amorphous alloys were fabricated by adding Ti, Zr, V, Ni, Al, and Be into a Ti-6Al-4V alloy by a vacuum arc melting method. The effective sizes of dendrites varied from 63 to 104 mu m, while their volume fractions were almost constant within the range from 74 to 76 pct. The observation of the microfracture of the alloy containing coarse dendrites revealed that a microcrack initiated at the amorphous matrix of the notch tip and propagated along the amorphous matrix. In the alloy containing fine dendrites, the crack propagation was frequently blocked by dendrites, and many deformation bands were formed near or in front of the propagating crack, thereby resulting in a zig-zag fracture path. Crack initiation toughness was almost the same at 35 to 36 MPaaem within error ranges in the three alloys because it was heavily affected by the stress applied to the specimen at the time of crack initiation at the crack tip as well as strength levels of the alloys. According to the R-curve behavior, however, the best overall fracture properties in the alloy containing fine dendrites were explained by mechanisms of blocking of the crack growth and crack blunting and deformation band formation at dendrites. (C) The Minerals, Metals & Materials Society and ASM International 2015ope

THE KINETIC AND MECHANISM OF CRYSTALLIZATION OF MGGEO3 IN 65GEO2-15PBO-10MGF2-10MGO GLASS SYSTEM

In this study, the crystallization behavior of a 65GeO2-15PbO-10MgF2-10MgO glass (prepared by the conventional melt quenching technique) has been investigated. The microstructure and crystallization behaviors of this glass were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), non-isothermal differential thermal analysis (DTA) and Fourier transform infrared spectroscopy (FTIR). The results demonstrated that a fully glassy phase can successfully be prepared by the conventional melt quenching technique exhibiting one-stage crystallization on heating, i.e., the glassy phase transforms into crystalline MgGeO3 and Pb5GeO7 phases. The activation energy for the crystallization, evaluated from the Kissinger equation, was approximately 202±5 kJ/mole using the peak temperature of the exothermic reaction. The Avrami exponent or reaction order, n, indicates the nucleation rate in this glass to increase with time and the crystallization to be governed by a three-dimensional interface-controlled growth

Fabrication and precipitation hardening characterization of nanostructure A17075 alloy

30-34<span style="font-size: 9.0pt;mso-bidi-font-size:10.0pt" lang="EN-US">In this paper the fabrication and precipitation hardening behavior of bulk nanostructure A17075 alloy is investigated. In order to produce this alloy, the elemental powder based on the nominal composition of conventional A17075 alloy is milled up to 15 h and then hot pressed. The milled and hot pressed samples are characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and differential thermal analysis (DTA). The results show that after 15 h of milling, the alloying elements are dissolved in Al matrix and a supersaturated solid solution with average crystallite size of about 30±5 nm is obtained. Hot pressing the powder samples at 500°C under 400 MPa led to the fully dense bulk nanostructure A17075 alloy. The consolidated sample has a hardness value of 165 HV which increases to 240 HV after appropriation hardening. </span

<span style="font-size:15.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:FA">Fabrication and characterization of amorphous-nanocrystalline <span style="font-size:15.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">Al₈₀Fe₁₀Ti₅M₃B₂ (M=Cr, Ni and Nb) <span style="font-size:15.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:FA">alloys</span></span></span>

307-312In this study, the formation and characterization of amorphous-nanocrystalline phases in Al80Fe10Ti5M3B2 (M=Cr, Ni and Nb) powder mixtures by the means of mechanical alloying (MA) have been investigated. The milled samples are characterized using X-ray diffraction (XRD), differential scanning calorimetry (DSC) and transmission electron microscopy (TEM). Mechanical alloying of these alloying systems shows that amorphous phase can be formed only in Al80Fe10Ti5Ni3B2 powder mixture and the final products in other systems are combination of amorphous and nanocrystalline phases. The produced amorphous phase in different alloying systems, exhibits one-stage crystallization on on heating (atat temperature up than temperature higher than 800oC) and the crystallization’s activation energy is more than 240±20 kJ/mol. The crystallization products (Al13Fe4) and mechanism (polymorphism) of amorphous phase in these three systems are the same.</span