Characterizing the Brazilian Term Structure of Interest Rates

This paper studies the Brazilian term structure of interest rates and characterizes how the term premia has changed over time. We employ a Kalman filter approach, which is extended to take into account regime switches and overlapping forecasts errors. Empirical evidence suggests that term premia depends on international global liquidity and domestic factors such as the composition of public debt and inflation volatility. These results provide guidance for the formulation of fiscal and monetary policies.

New modelling technique for aperiodic-sampling linear systems

A general input-output modelling technique for aperiodic-sampling linear systems has been developed. The procedure describes the dynamics of the system and includes the sequence of sampling periods among the variables to be handled. Some restrictive conditions on the sampling sequence are imposed in order to guarantee the validity of the model. The particularization to the periodic case represents an alternative to the classic methods of discretization of continuous systems without using the Z-transform. This kind of representation can be used largely for identification and control purposes.Comment: 19 pages, 0 figure

War-Gaming Applications for Achieving Optimum Acquisition of Future Space Systems

This chapter describes an innovative modeling and simulation approach using newly proposed Advanced Game-based Mathematical Framework (AGMF), Unified Game-based Acquisition Framework (UGAF) and a set of War-Gaming Engines (WGEs) to address future space systems acquisition challenges. Its objective is to assist the DoD Acquisition Authority (DAA) to understand the contractor’s perspective and to seek optimum Program-and-Technical-Baseline (PTB) solution and corresponding acquisition strategy under both the perspectives of the government and the contractors. The proposed approach calls for an interdisciplinary research that involves game theory, probability and statistics, and non-linear programming. The goal of this chapter is to apply the proposed war-gaming frameworks to develop and evaluate PTB solutions and associated acquisition strategies in the context of acquisition of future space systems. Our simulation results suggest that our optimization problem for the acquisition of future space systems meets the affordability and innovative requirements with minimum acquisition risk

Teleparallel Spin Connection

A new expression for the spin connection of teleparallel gravity is proposed, given by minus the contorsion tensor plus a zero connection. The corresponding minimal coupling is covariant under local Lorentz transformation, and equivalent to the minimal coupling prescription of general relativity. With this coupling prescription, therefore, teleparallel gravity turns out to be fully equivalent to general relativity, even in the presence of spinor fields.Comment: 2 pages, RevTeX, to appear in Phys. Rev D (Brief Report

Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts

β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. We have determined that this transitory arrest was dependent on the cell-cycle regulator protein Retinoblastoma. Moreover, dermal fibroblasts increase their migration capacities at 24 h after barley β-glucan addition. Also, we have described that barley β-glucan strongly reduced the ability of fibroblasts to attach and to spread on cell plates. Our data indicates that barley β-glucan signal induces an early response in HDF cells favoring migration versus proliferation. This feature is consistent with our observation that the topical addition of our barley β-glucan in vivo accelerates the wound closure in mouse skin

Inventario de mamíferos medianos y grandes en la reserva los Titíes de San Juan, Montes de María, Bolívar, Colombia

We report the inventory of medium and large mammals for the National Reserve of the Civil Society Los Titíes de San Juan in the Bolívar department. A total of eight orders were registered, 18 families and 22 species, two of them are in danger of extinction Saguinus oedipus and Ateles fusciceps. We highlight the presence and most recent photographic record of Galictis vittata. We stands out the importance of establishing protected areas that provide connectivity with forest fragments and protection of endangered species.Reportamos el inventario de mamíferos medianos y grandes para la Reserva Nacional de la Sociedad Civil Los Titíes de San Juan en el departamento de Bolívar. Se registraron un total de ocho ordenes, 18 familias y 22 especies, de los cuales dos se encuentran en peligro de extinción Saguinus oedipus y Ateles fusciceps. Resaltamos la presencia y más reciente registro fotográfico de Galictis vittata. Se destaca la importancia de establecer áreas protegidas que provean conectividad  con fragmentos de bosques y protección de especies amenazadas.   &nbsp

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

ω3-polyunsaturated free fatty acids (ω3-PUFAs), particularly docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), are thought to exert health promoting effects in metabolic and in inflammatory diseases. The molecular mechanisms of these beneficial effects are only partially understood. DHA and EPA activate Free Fatty Acid receptor 4 (GPR120/FFA4). Recently, the first orally available, synthetic ligand of FFA4, 3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid ("compound A"; cpd A) has been developed. Cpd A exhibits distinctly higher potency, efficiency, and selectivity at FFA4 than ω3-PUFAs and ameliorates insulin resistance and adipose tissue inflammation in the mouse. With GPR120/FFA4 activation believed to also attenuate tissue inflammation in autoimmune diseases, cpd A may also have a beneficial effect in these diseases. We have therefore addressed the therapeutic potential of cpd A in mouse models of three prototypical autoimmune diseases, specifically psoriasis, rheumatoid arthritis, and bullous pemphigoid. The effect of cpd A on the course of Aldara™-induced psoriasis-like dermatitis, K/BxN serum transfer arthritis, and antibody transfer pemphigoid disease-like dermatitis was scrutinized. Cpd A did not alter the course of Aldara-induced psoriasis-like dermatitis, K/BxN serum transfer arthritis, or antibody transfer pemphigoid disease-like dermatitis. Our results suggest that therapeutic regimens solely relying on FFA4 activation do not bear the potential to treat inflammatory diseases. With cpd A distinctly more potent in activating GPR120/FFA4 than ω3-PUFAs, this also suggests that GPR120/FFA4 activation by ω3-PUFAs does not significantly contribute to the health-promoting effects of ω3-PUFAs in autoimmune diseases

Influence of Market Type and Time of Purchase on Bacterial Counts and Salmonella and Listeria Prevalence in Whole Chickens in Vietnam

The objective of the current study was to determine the influence of market type and sampling time on Salmonella and Listeria prevalence and bacterial counts of 180 whole chicken carcasses collected from 6 supermarkets (SM), 6 indoor markets (IM), and 6 open markets (OM) in Vietnam, at opening (T0) and 4 h after the opening (T4). Salmonella and Listeria prevalence was at least 25.6% and 42.7%, respectively. Whole birds in IM had greater Salmonella prevalence than birds from both SM and OM by 28.4% and 23.0% (P = 0.006 and 0.022, respectively). Listeria prevalence was lower in whole chickens from SM, at 56.6%, than those in IM and OM (78.6% and 73.2%, P = 0.024 and 0.089, respectively). Whole chicken carcasses had more than 10.1, 7.5, and 9.4 log colony-forming units (CFU)/g of aerobic bacteria, Escherichia coli (E. coli), and coliforms, respectively. Both E. coli and coliform counts were greater in IM than in SM (P = 0.002 and 0.006). However, only E. coli counts differed between SM (7.7 log CFU/g) and OM (8.3 log CFU/g; P = 0.024). These results highlighted high levels of bacteria and high prevalence of Salmonella and Listeria in whole chickens in retail establishments in Vietnam, posing potential food safety and public health risks