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Expansion of the half retinal projection to the tectum in goldfish: An electrophysiological and Anatomical study
The topographical retino-tectal projection of goldfish was electrophysiologically mapped at various intervals after surgical removal of the nasal half of the retina and pigment epithelium. The remaining projection was initially restricted to the appropriate rostral half of the tectum, even if the nerve was crushed and allowed to regenerate. But later, after 137 days or more, it showed a progressive expansion onto the foreign caudal half of the tectum. The magnification factor, the number of micrometers of tectum per degree in the visual field, doubled in the rostro-caudal but not in the medio-lateral direction. Analysis of the sequence of the expansion showed that a few fibers originally projecting nearest the denervated area were the first to spread over it. Then, progressively more fibers moved caudally until a nearly uniform representation of the half retina was established on the tectum. Radioautography also demonstrated that retinal fiber terminals had invaded the caudal tectum. The retinae of these fish were also examined histologically. The density of ganglion cells had not increased, but they consistently showed the axonal reaction. This was not found to be associated with any initial surgical trauma, but rather with the movement of their fiber terminals within the tectum. Frozen sections, through half retinal and normal eyes, were cut and photographed for comparison of ocular geometry. Operated eyes were normal except for a slight but consistent loss of ocular volume. Analysis of the optical geometry showed that recording with fish in air produced two effects: Myopia (10° blur circle, or less) and enlargement of the visual field by 15% to 20%.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50003/1/901770206_ftp.pd
One-laser interferometric broadband coherent anti-Stokes Raman scattering
We introduce an interferometric technique for eliminating the non-resonant background of broadband coherent anti-Stokes Raman scattering (CARS) microscopy. CARS microscopy has been used for imaging a number of biological samples and processes, but the studies are mostly limited to detecting lipids in biological systems by probing the C-H stretch. Non-resonant background and incoherent noise sources can easily overwhelm less intense signals from other molecular vibrations. In this study, we demonstrate a one-laser broadband interferometric technique that separates the spontaneous Raman scattering-related component of the CARS signal from the non-resonant background using liquid benzonitrile as a model system.Tak W. Kee, Hongxia Zhao, and Marcus T. Ciceron
Heterogeneous Diffusion in Highly Supercooled Liquids
The diffusivity of tagged particles is demonstrated to be very heterogeneous
on time scales comparable to or shorter than the relaxation time
( the stress relaxation time) in a highly supercooled
liquid via 3D molecular dynamics simulation. The particle motions in the
relatively active regions dominantly contribute to the mean square
displacement, giving rise to a diffusion constant systematically larger than
the Einstein-Stokes value. The van Hove self-correlation function is
shown to have a long distance tail which can be scaled in terms of
for t \ls 3\tau_{\alpha}. Its presence indicates heterogeneous diffusion in
the active regions. However, the diffusion process eventually becomes
homogeneous on time scales longer than the life time of the heterogeneity
structure ().Comment: 4 pages, 5 figure
Dynamical heterogeneities in a supercooled Lennard-Jones liquid
We present the results of a large scale molecular dynamics computer
simulation study in which we investigate whether a supercooled Lennard-Jones
liquid exhibits dynamical heterogeneities. We evaluate the non-Gaussian
parameter for the self part of the van Hove correlation function and use it to
identify ``mobile'' particles. We find that these particles form clusters whose
size grows with decreasing temperature. We also find that the relaxation time
of the mobile particles is significantly shorter than that of the bulk, and
that this difference increases with decreasing temperature.Comment: 8 pages of RevTex, 4 ps figure
Anisotropic Local Stress and Particle Hopping in a Deeply Supercooled Liquid
The origin of the microscopic motions that lead to stress relaxation in
deeply supercooled liquid remains unclear. We show that in such a liquid the
stress relaxation is locally anisotropic which can serve as the driving force
for the hopping of the system on its free energy surface. However, not all
hopping are equally effective in relaxing the local stress, suggesting that
diffusion can decouple from viscosity even at local level. On the other hand,
orientational relaxation is found to be always coupled to stress relaxation.Comment: 4 pages, 3 figure
Structural Relaxation, Self Diffusion and Kinetic Heterogeneity in the Two Dimensional Lattice Coulomb Gas
We present Monte Carlo simulation results on the equilibrium relaxation
dynamics in the two dimensional lattice Coulomb gas, where finite fraction
of the lattice sites are occupied by positive charges. In the case of high
order rational values of close to the irrational number
( is the golden mean), we find that the system
exhibits, for wide range of temperatures above the first-order transition, a
glassy behavior resembling the primary relaxation of supercooled liquids.
Single particle diffusion and structural relaxation show that there exists a
breakdown of proportionality between the time scale of diffusion and that of
structural relaxation analogous to the violation of the Stokes-Einstein
relation in supercooled liquids. Suitably defined dynamic cooperativity is
calculated to exhibit the characteristic nature of dynamic heterogeneity
present in the system.Comment: 12 pages, 20 figure
String-like Clusters and Cooperative Motion in a Model Glass-Forming Liquid
A large-scale molecular dynamics simulation is performed on a glass-forming
Lennard-Jones mixture to determine the nature of dynamical heterogeneities
which arise in this model fragile liquid. We observe that the most mobile
particles exhibit a cooperative motion in the form of string-like paths
(``strings'') whose mean length and radius of gyration increase as the liquid
is cooled. The length distribution of the strings is found to be similar to
that expected for the equilibrium polymerization of linear polymer chains.Comment: 6 pages of RevTex, 6 postscript figures, uses epsf.st
Hole-burning experiments within solvable glassy models
We reproduce the results of non-resonant spectral hole-burning experiments
with fully-connected (equivalently infinite-dimensional) glassy models that are
generalizations of the mode-coupling approach to nonequilibrium situations. We
show that an ac-field modifies the integrated linear response and the
correlation function in a way that depends on the amplitude and frequency of
the pumping field. We study the effect of the waiting and recovery-times and
the number of oscillations applied. This calculation will help descriminating
which results can and which cannot be attributed to dynamic heterogeneities in
real systems.Comment: 4 pages, 8 figures, RevTe
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