382 research outputs found
Lagrangian temperature, velocity and local heat flux measurement in Rayleigh-Benard convection
We have developed a small, neutrally buoyant, wireless temperature sensor.
Using a camera for optical tracking, we obtain simultaneous measurements of
position and temperature of the sensor as it is carried along by the flow in
Rayleigh-B\'enard convection, at . We report on statistics of
temperature, velocity, and heat transport in turbulent thermal convection. The
motion of the sensor particle exhibits dynamics close to that of Lagrangian
tracers in hydrodynamic turbulence. We also quantify heat transport in plumes,
revealing self-similarity and extreme variations from plume to plume.Comment: 4 page
Predicting criticality and dynamic range in complex networks: effects of topology
The collective dynamics of a network of coupled excitable systems in response
to an external stimulus depends on the topology of the connections in the
network. Here we develop a general theoretical approach to study the effects of
network topology on dynamic range, which quantifies the range of stimulus
intensities resulting in distinguishable network responses. We find that the
largest eigenvalue of the weighted network adjacency matrix governs the network
dynamic range. Specifically, a largest eigenvalue equal to one corresponds to a
critical regime with maximum dynamic range. We gain deeper insight on the
effects of network topology using a nonlinear analysis in terms of additional
spectral properties of the adjacency matrix. We find that homogeneous networks
can reach a higher dynamic range than those with heterogeneous topology. Our
analysis, confirmed by numerical simulations, generalizes previous studies in
terms of the largest eigenvalue of the adjacency matrix.Comment: 4 pages, 3 figure
Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing.
Recent efforts to comprehensively characterize great ape genetic diversity using short-read sequencing and single-nucleotide variants have led to important discoveries related to selection within species, demographic history, and lineage-specific traits. Structural variants (SVs), including deletions and inversions, comprise a larger proportion of genetic differences between and within species, making them an important yet understudied source of trait divergence. Here, we used a combination of long-read and -range sequencing approaches to characterize the structural variant landscape of two additional Pan troglodytes verus individuals, one of whom carries 13% admixture from Pan troglodytes troglodytes. We performed optical mapping of both individuals followed by nanopore sequencing of one individual. Filtering for larger variants (>10 kbp) and combined with genotyping of SVs using short-read data from the Great Ape Genome Project, we identified 425 deletions and 59 inversions, of which 88 and 36, respectively, were novel. Compared with gene expression in humans, we found a significant enrichment of chimpanzee genes with differential expression in lymphoblastoid cell lines and induced pluripotent stem cells, both within deletions and near inversion breakpoints. We examined chromatin-conformation maps from human and chimpanzee using these same cell types and observed alterations in genomic interactions at SV breakpoints. Finally, we focused on 56 genes impacted by SVs in >90% of chimpanzees and absent in humans and gorillas, which may contribute to chimpanzee-specific features. Sequencing a greater set of individuals from diverse subspecies will be critical to establish the complete landscape of genetic variation in chimpanzees
Effects of network topology, transmission delays, and refractoriness on the response of coupled excitable systems to a stochastic stimulus
We study the effects of network topology on the response of networks of
coupled discrete excitable systems to an external stochastic stimulus. We
extend recent results that characterize the response in terms of spectral
properties of the adjacency matrix by allowing distributions in the
transmission delays and in the number of refractory states, and by developing a
nonperturbative approximation to the steady state network response. We confirm
our theoretical results with numerical simulations. We find that the steady
state response amplitude is inversely proportional to the duration of
refractoriness, which reduces the maximum attainable dynamic range. We also
find that transmission delays alter the time required to reach steady state.
Importantly, neither delays nor refractoriness impact the general prediction
that criticality and maximum dynamic range occur when the largest eigenvalue of
the adjacency matrix is unity
A Classic Question Revisited in Red-winged Blackbirds: Disentangling Confounding Hypotheses Surrounding Parental Investment Theory and Nest Defense Intensity
The pattern of increased nest-defense effort over the course of a nesting season could result from 3 distinct (albeit non-exclusive) mechanisms: increased value of offspring to parents with progression towards independence (parental-investment theory), decreased opportunity for renesting (renesting-potential hypothesis), or decreased perceived costs of defense after repeated encounters with human observers (positive-reinforcement hypothesis). To gauge relative empirical support for each of these mechanisms, we disentangle these 3 often-confounded hypotheses using multi-model inference with mixed-model ordinal regression applied to an extensive red-winged blackbird (Agelaius phoeniceus) nesting data set (4,518 monitoring visits to 1,330 nests). Parent aggression was rated on an ordinal scale (0-4) during repeated monitoring visits. Additionally, we assessed clutch/brood size, nest density, time of day, and nest concealment effects on aggression. In a preliminary analysis, including all 3 major hypotheses, male and female nest defense was most strongly explained by parental investment (nest age). Positive-reinforcement (visit number) and renesting potential (Julian date), were also well-supported predictors in males. The interactions of decomposed nest age (within- and between individual centered) with Julian date were particularly important in the top male model. Additional factors, such as clutch/brood size, nest density, and nest concealment appeared to have larger predictive roles in explaining female aggression relative to males. These patterns are likely explained by different sexual reproductive roles within a polygynous mating system. Our study highlights the importance of interacting mechanisms involving parental investment theory and the use of within-individual standardization to help disentangle competing, and empirically confounded hypotheses
Avalanches in self-organized critical neural networks: A minimal model for the neural SOC universality class
The brain keeps its overall dynamics in a corridor of intermediate activity
and it has been a long standing question what possible mechanism could achieve
this task. Mechanisms from the field of statistical physics have long been
suggesting that this homeostasis of brain activity could occur even without a
central regulator, via self-organization on the level of neurons and their
interactions, alone. Such physical mechanisms from the class of self-organized
criticality exhibit characteristic dynamical signatures, similar to seismic
activity related to earthquakes. Measurements of cortex rest activity showed
first signs of dynamical signatures potentially pointing to self-organized
critical dynamics in the brain. Indeed, recent more accurate measurements
allowed for a detailed comparison with scaling theory of non-equilibrium
critical phenomena, proving the existence of criticality in cortex dynamics. We
here compare this new evaluation of cortex activity data to the predictions of
the earliest physics spin model of self-organized critical neural networks. We
find that the model matches with the recent experimental data and its
interpretation in terms of dynamical signatures for criticality in the brain.
The combination of signatures for criticality, power law distributions of
avalanche sizes and durations, as well as a specific scaling relationship
between anomalous exponents, defines a universality class characteristic of the
particular critical phenomenon observed in the neural experiments. The spin
model is a candidate for a minimal model of a self-organized critical adaptive
network for the universality class of neural criticality. As a prototype model,
it provides the background for models that include more biological details, yet
share the same universality class characteristic of the homeostasis of activity
in the brain.Comment: 17 pages, 5 figure
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Genomic structural variation: A complex but important driver of human evolution
Structural variants (SVs)-including duplications, deletions, and inversions of DNA-can have significant genomic and functional impacts but are technically difficult to identify and assay compared with single-nucleotide variants. With the aid of new genomic technologies, it has become clear that SVs account for significant differences across and within species. This phenomenon is particularly well-documented for humans and other primates due to the wealth of sequence data available. In great apes, SVs affect a larger number of nucleotides than single-nucleotide variants, with many identified SVs exhibiting population and species specificity. In this review, we highlight the importance of SVs in human evolution by (1) how they have shaped great ape genomes resulting in sensitized regions associated with traits and diseases, (2) their impact on gene functions and regulation, which subsequently has played a role in natural selection, and (3) the role of gene duplications in human brain evolution. We further discuss how to incorporate SVs in research, including the strengths and limitations of various genomic approaches. Finally, we propose future considerations in integrating existing data and biospecimens with the ever-expanding SV compendium propelled by biotechnology advancements
Superficial femoral popliteal vein: An anatomic study
AbstractObjective : The superficial femoral popliteal vein (SFPV) has been used as an alternative conduit for both arterial and venous reconstructive surgery. Its popularity continues to grow, despite concern about the potential for venous morbidity after harvest. The purpose of this study was to determine an anatomic “safe” length of SFPV for harvest, assuming that the preservation of at least one valve and one significant collateral vein in the remaining popliteal vein (PV) segment can minimize venous morbidity. Methods : Forty-four SFPVs were harvested from 39 cadaveric specimens. The length of both the superficial femoral vein (SFV) and PV was measured, and the number and location of valves and significant side branches (more than 2 mm in diameter) of the PV were measured. The Student two-tailed t test was used as a means of comparing vein lengths between the sexes. Correlation coefficients were determined for the effect of patient height on vein length, stratified by means of sex. Results : Vein length (SFV mean, 24.4 ± 4 cm; PV mean, 18.8 ± 4 cm) varied with sex (male SFV mean, 28.1 ± 5 cm; male PV mean, 21.5 ± 3 cm; female SFV mean, 22.6 ± 4 cm; female PV mean, 18.4 ± 3 cm; P =.01). Valve number (mean, 1.8 ± 0.5) and location and collateral vein number (mean, 5 ± 1.8) and location were variable and independent of height or sex. Conclusion : An anatomic “safe” length of SFPV for harvest to minimize venous morbidity would include all the SFV and 12 cm of PV in 95% of women and 15 cm of PV in 95% of men. We found that the male sex was a significant determinant for a longer safe length of vein that can be harvested. (J Vasc Surg 2000;31:450-5.
Cascades and Cognitive State: Focused Attention Incurs Subcritical Dynamics
The analysis of neuronal avalanches supports the hypothesis that the human cortex operates with critical neural dynamics. Here, we investigate the relationship between cascades of activity in electroencephalogram data, cognitive state, and reaction time in humans using a multimodal approach. We recruited 18 healthy volunteers for the acquisition of simultaneous electroencephalogram and functional magnetic resonance imaging during both rest and during a visuomotor cognitive task. We compared distributions of electroencephalogram-derived cascades to reference power laws for task and rest conditions. We then explored the large-scale spatial correspondence of these cascades in the simultaneously acquired functional magnetic resonance imaging data. Furthermore, we investigated whether individual variability in reaction times is associated with the amount of deviation from power law form. We found that while resting state cascades are associated with approximate power law form, the task state is associated with subcritical dynamics. Furthermore, we found that electroencephalogram cascades are related to blood oxygen level-dependent activation, predominantly in sensorimotor brain regions. Finally, we found that decreased reaction times during the task condition are associated with increased proximity to power law form of cascade distributions. These findings suggest that the resting state is associated with near-critical dynamics, in which a high dynamic range and a large repertoire of brain states may be advantageous. In contrast, a focused cognitive task induces subcritical dynamics, which is associated with a lower dynamic range, which in turn may reduce elements of interference affecting task performance
Effects of Host Resistance on Germination of Cercospora arachidicola on Peanut Leaf Surfaces
Conidial germination by a North Carolina field-isolate of Cercospora arachidicola Hori was studied on leaf surfaces of two highly resistant and two susceptible peanut (Arachis hypogaea L.) genotypes under 5 day/night temperature regimes. Conidia germinated at all temperature regimes, but a greater percentage germinated at the coolest temperature regimes of 26 C day/20 C night and constant 24 C than in warmer temperature regimes. Percentage germination differed significantly with respect to time and genotype in each temperature regime. Fewer conidia germinated on resistant compared to susceptible genotypes, with lowest germination on the resistant genotype 91 PA 150 (a Virginia type derived from a cross of A. hypogaea and A. cardenasii Krapov. and W. C. Gregory). Conidia germinated more quickly and more conidia germinated overall on the susceptible NC 7 than on the other genotypes teste
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