Seizure semiology of anti‐LGI1 antibody encephalitis

Limbic encephalitis associated with anti‐LGI1 antibody (LGI1 encephalitis) presents with a variety of features, the most prominent of which include seizures and progressive disturbance of memory and behaviour. Although varied in semiology, recognition of the pattern of seizures in LGI1 encephalitis is important, as early diagnosis and definitive treatment may prevent subsequent development of cognitive impairment. We present a patient with LGI1 encephalitis and “faciobrachial dystonic seizures‐plus”, which began as classic faciobrachial dystonic seizures and progressed to focal seizures with impaired awareness, dacrystic/gelastic‐like outbursts, ictal speech, manual automatisms, and autonomic signs (tachycardia). Recognition of the broad range of seizure types associated with LGI1 encephalitis is crucial for early diagnosis and definitive treatment. [Published with video sequence on www.epilepticdisorders.com]Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142082/1/epd212047.pd

Identification of different types of kink modes in coronal loops: principles and application to TRACE results

We explore the possible observational signatures of different types of kink modes (horizontal and vertical oscillations in their fundamental mode and second harmonic) that may arise in coronal loops, with the aim of determining how well the individual modes can be uniquely identified from time series of images. A simple, purely geometrical model is constructed to describe the different types of kink-mode oscillations. These are then `observed' from a given direction. In particular, we employ the 3D geometrical parameters of 14 TRACE loops of transverse oscillations to try to identify the correct observed wave mode. We find that for many combinations of viewing and loop geometry it is not straightforward to distinguish between at least two types of kink modes just using time series of images. We also considered Doppler signatures and find that these can help obtain unique identifications of the oscillation modes when employed in combination with imaging. We then compare the modeled spatial signatures with the observations of 14 TRACE loops. We find that out of three oscillations previously identified as fundamental horizontal mode oscillations, two cases appear to be fundamental vertical mode oscillations (but possibly combined with the fundamental horizontal mode), and one case appears to be a combination of the fundamental vertical and horizontal modes, while in three cases it is not possible to clearly distinguish between the fundamental mode and the second-harmonic of the horizontal oscillation. In five other cases it is not possible to clearly distinguish between a fundamental horizontal mode and the second-harmonic of a vertical mode.Comment: 12 pages, 10 figures, 2 tables. A&A in pres

Role of Acanthamoeba in urinary tract infections

Urinary Tract Infection (UTI) is the second most common healthcare associated infections (HCAI) in England. The HCAI prevalence survey data (2011) released by the Health Protection Agency (HPA) shows that UTI’s are the second most common HCAI accounting for 17.2% of the total HCAI’s in England. Escherichia coli, Klebsiella and Proteus are Gram negative bacteria frequently associated with UTI's. More HCAI's are related to the use of urinary catheters than any other medical device. An estimated 450,000 people in the UK use catheters on a long-term basis. Uropathogens are known to form biofilms on catheters causing recurrent infections. Biofilms are difficult to eradicate due to decreased antibiotic susceptibility and increased resistance. A recent study has found the presence of Acanthamoeba in urine of critically ill patients. The ubiquitous protozoan Acanthamoeba, is an opportunistic pathogen well recognised to serve as a reservoir for prokaryotes. Our recent findings (unpublished) confirm that the above mentioned bacteria can invade, survive and multiply within Acanthamoeba evading host defence and antibiotic action by forming cysts. It is our intention to investigate the presence of Acanthamoeba in urine samples collected from patients

Stiffness of Extracellular Matrix Components Modulates the Phenotype of Human Smooth Muscle Cells in Vitro and Allows for the Control of Properties of Engineered Tissues

AbstractSmooth muscle cells (SMCs) play a significant role in the pathogenesis of atherosclerosis. 2D cultures elucidated valuable information about the interaction between SMCs and extracellular matrix (ECM) components. However, 3D constructs better represent the native vascular environment. Furthermore, a limited number of studies addressed the effect of ECM stiffness on SMCs phenotype. We investigated the effect of stiffness of different ECM substrates by modulating their concentrations, including the effect on morphology, proliferation, expression of the contractile protein α-smooth muscle actin (α-SMA) and deposition of collagen type I (Col I) and collagen type III (Col III) proteins. At low concentrations of Col I gels and Col I gels supplemented with 10% fibronectin (Fn), SMCs exhibited non-elongated, ‘hill-and-valley’ shape and large mean cellular area, indicating a hypertrophic morphology, characteristic of the synthetic phenotype. However, with increasing concentration, mean cellular area and proliferation relative to cells cultured in 2D dropped. Whole protein secretion into the culture media and deposition of Col I and Col III generally decreased with increasing stiffness. Moreover, percentage of α-SMA+ SMCs decreased with increasing gel concentration, pointing to a shift towards the synthetic phenotype. Supplementing Col I with 10% Laminin (Ln) maintained higher cellular area and aspect ratio at all gel concentrations and did not change α-SMA expression significantly, compared to Col I alone or Col I + Fn. Overall, these results demonstrate that ECM components and stiffness could provide the tools to modulate the phenotype and function of SMCs in vitro, which allows for the control of properties of engineered tissues

Assessment of Guneid Sugar Factory social impacts

ABSTRACT  Sugar is one of the most important and oldest commodities in the world. In the Sudan, there are two types of sugar estates; public and private. Sugar industry in the Sudan is one of the  important and effective industries for the Sudanese economy. In addition, sugar cane production schemes in the Sudan are very effective with regard to community development and wealth distribution. The objective of this study was to assess the social impacts of Guneid Sugar Factory which is a public and first sugar factory in the Sudan. Like other sugar factories, Guneid Sugar Factory has a significant role in the Sudan economy, as well as in the social development of the area.  This factory differs slightly from all sugar factories in Sudan, because it operates by tenants who belonged to Gezira Scheme before the establishment of the factory. The study used primary data through a questionnaire with a random sample from Guneid tenants and used descriptive statistics for analysis. The study showed that the scheme substantially contributed to the establishment of schools, health centers, hospitals, provision of electricity, healthy drinking water and increased the income of inhabitants. The study concluded that, Guneid is providing excellent social services that have apparent contribution to the improvement of the livelihood of the communities

Letters to the Editor

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65933/1/j.1528-1157.1995.tb00479.x.pd

Excitation of standing kink oscillations in coronal loops

In this work we review the efforts that have been done to study the excitation of the standing fast kink body mode in coronal loops. We mainly focus on the time-dependent problem, which is appropriate to describe flare or CME induced kink oscillations. The analytical and numerical studies in slab and cylindrical loop geometries are reviewed. We discuss the results from very simple one-dimensional models to more realistic (but still simple) loop configurations. We emphasise how the results of the initial value problem complement the eigenmode calculations. The possible damping mechanisms of the kink oscillations are also discussed

Value of Inpatient Diagnostic CCTV-EEG Monitoring in the Elderly

Purpose: To examine the outcome of inpatient diagnostic closed circuit TV-EEG (CCTV-EEG) monitoring in a consecutive series of elderly patients admitted to an adult epilepsy-monitoring unit (EMU) over a continuous 6-year period. Methods: Retrospective review of all admissions to a university hospital adult EMU. Those older than 60 years were identified. Patients who were monitored for status epilepticus were excluded. Data on duration of events, frequency of events, physical examination, medications, preadmission EEG, brain imaging, length of stay, and interictal and ictal EEG were obtained. Results: Of the 18 patients admitted for monitoring only, mean age was 69.5 years (range, 60–90 years). Mean length of stay was 4.3 days (range, 2–9 days). Five patients had complex partial seizures recorded. Three patients, all treated with antiepileptic drugs (AEDs), had no spells recorded, and no additional diagnostic information was gained from the admission. The other 10 patients, eight of whom had been treated with AEDs, were symptomatic during their admission, leading to a variety of neurologic but not epileptic, psychiatric, or other medical disorders, and allowing tapering of AEDs. Conclusions: In elderly patients with suspected epilepsy, CCTV-EEG is a very useful diagnostic tool. In this series of 18, 10 patients were diagnosed with potentially treatable medical illnesses not responsive to AEDs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65172/1/j.1528-1157.1999.tb00825.x.pd

Forced oscillations of coronal loops driven by external EIT waves

Aims. We study the generation of transversal oscillations in coronal loops represented as a straight thin flux tube under the effect of an external driver modelling the global coronal EIT wave. We investigate how the generated oscillations depend on the nature of the driver, and the type of interaction between the two systems. Methods. We consider the oscillations of a magnetic straight cylinder with fixed-ends under the influence of an external driver modelling the force due to the global EIT wave. Given the uncertainties related to the nature of EIT waves, we first approximate the driver by an oscillatory force in time and later by a shock with a finite width. Results. Results show that for a harmonic driver the dominant period in the generated oscillation belongs to the driver. Depending on the period of driver, compared to the natural periods of the loop, a mixture of standing modes harmonics can be initiated. In the case of a non-harmonic driver (modelling a shock wave), the generated oscillations in the loop are the natural periods only. The amplitude of oscillations is determined by the position of the driver along the tube. The full diagnosis of generated oscillations is achieved using simple numerical methods

Forced oscillations of coronal loops driven by external EIT waves

Aims. We study the generation of transversal oscillations in coronal loops represented as a straight thin flux tube under the effect of an external driver modelling the global coronal EIT wave. We investigate how the generated oscillations depend on the nature of the driver, and the type of interaction between the two systems. Methods. We consider the oscillations of a magnetic straight cylinder with fixed-ends under the influence of an external driver modelling the force due to the global EIT wave. Given the uncertainties related to the nature of EIT waves, we first approximate the driver by an oscillatory force in time and later by a shock with a finite width. Results. Results show that for a harmonic driver the dominant period in the generated oscillation belongs to the driver. Depending on the period of driver, compared to the natural periods of the loop, a mixture of standing modes harmonics can be initiated. In the case of a non-harmonic driver (modelling a shock wave), the generated oscillations in the loop are the natural periods only. The amplitude of oscillations is determined by the position of the driver along the tube. The full diagnosis of generated oscillations is achieved using simple numerical methods