98 research outputs found
Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis
We used chemical genetics to control the activity of budding yeast Prk1p, which is a protein kinase that is related to mammalian GAK and AAK1, and which targets several actin regulatory proteins implicated in endocytosis. In vivo Prk1p inhibition blocked pheromone receptor endocytosis, and caused cortical actin patches to rapidly aggregate into large clumps that contained Abp1p, Sla2p, Pan1p, Sla1p, and Ent1p. Clump formation depended on Arp2p, suggesting that this phenotype might result from unregulated Arp2/3-stimulated actin assembly. Electron microscopy/immunoelectron microscopy analysis and tracking of the endocytic membrane marker FM4-64 revealed vesicles of likely endocytic origin within the actin clumps. Upon inhibitor washout, the actin clumps rapidly disassembled, and properly polarized actin patches reappeared. Our results suggest that actin clumps result from blockage at a normally transient step during which actin assembly is stimulated by endocytic proteins. Thus, we revealed tight phosphoregulation of an intrinsically dynamic, actin patch–related process, and propose that Prk1p negatively regulates the actin assembly–stimulating activity of endocytic proteins
Search for the X(1812) in
We report on a search for the X(1812) state in the decay with a data sample of pairs collected
with the Belle detector at the KEKB collider. No significant signal is
observed. An upper limit (90% C.L.) is determined. We also constrain the
three-body decay branching fraction to be 1.9 (90% C.L.).Comment: 5pages,2 figures(3 figure files). submitted to PRD(RC
Search for B+ -> D*+ pi0 decay
We report on a search for the doubly Cabibbo suppressed decay B+ -> D*+ pi0,
based on a data sample of 657 million BBbar pairs collected at the Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric energy e+ e- collider.
We find no significant signal and set an upper limit of Br(B+ -> D*+ pi0) < 3.6
x 10^-6 at the 90% confidence level. This limit can be used to constrain the
ratio between suppressed and favored B -> D* pi decay amplitudes, r < 0.051, at
the 90% confidence level.Comment: 5pages, 2figures, submitted to PRL (v1); PRL published version (v2:
minor corrections in the text
Measurements of Charmless Hadronic b->s Penguin Decays in the pi+pi-K+pi- Final State and First Observation of B0 -> rho0K+pi-
We report measurements of charmless hadronic B^0 decays into the pi+pi-K+pi+
final state. The analysis uses a sample of 657x10^6 BBbar pairs collected with
the Belle detector at the KEKB asymmetric-energy e+e- collider at the Y(4S)
resonance. The decay B^0 -> rho0 Kpi is observed for the first time; the
significance is 5.0sigma and the corresponding partial branching fraction for
M_Kpi in (0.75,1.20) GeV/c^2 is [2.8 +- 0.5(stat) +-0.5(syst)] x 10^{-6}. We
also obtain the first evidence for B^0 -> f0Kpi with 3.5sigma significance and
for B^0 -> pi+pi-K*0 with 4.5sigma significance. For the two-body decays B^0 ->
rho0K*0 and B^0 -> f0K*0, the significances are 2.7sigma and 2.5sigma,
respectively, and the upper limits on the branching fractions are 3.4x10^{-6}
and 2.2x10^{-6} at 90% confidence level.Comment: 6 pages, 3 figures. accepted by PRD(RC
Time-dependent CP Asymmetries in Decays
We report the first measurement of CP-violation parameters in B^0 ->
K_S^0\rho^0\gamma decays based on 657 million B\bar B pairs collected with the
Belle detector at the KEKB asymmetric-energy collider. We measure the
time-dependent CP violating parameter S_{K_S^0\rho^0\gamma}= 0.11 +/-
0.33(stat.)^{+0.05}_{-0.09}(syst.). We also obtain the effective direct CP
violating parameter A_eff=0.05 +/- 0.18(stat.) +/- 0.06(syst.) for
m_{K_S\pi^+\pi^-}<1.8 GeV/c^2 and 0.6 GeV/c^2<m_{\pi^+\pi^-}<0.9 GeV/c^2.Comment: 6 pages, 3 figures, to be submitted to PR
Evidence for at Belle
We present a measurement of the branching fraction for the Cabibbo- and
color-suppressed decay based on a data sample of
events collected at the resonance
with the Belle detector at the KEKB asymmetric-energy collider. We
observe a signal of events with a significance of
including systematic uncertainties. The measured branching fraction is
.Comment: 5 pages, 5 figure
Dalitz analysis of B --> K pi psi' decays and the Z(4430)+
From a Dalitz plot analysis of B --> K pi psi' decays, we find a signal for
Z(4430)+ --> pi+ psi' with a mass M= (4443(+15-12)(+19-13))MeV/c^2, width
Gamma= (107(+86-43)(+74-56))MeV, product branching fraction BR(B0 --> K-
Z(4430)+) x BR(Z(4430)+ --> pi+ psi')= (3.2(+1.8-0.9)(+5.3-1.6)) x 10^{-5}, and
significance of 6.4sigma that agrees with previous Belle measurements based on
the same data sample. In addition, we determine the branching fraction BR(B^0
--> K*(892)^0 psi')= (5.52(+0.35-0.32)(+0.53-0.58)) x 10^{-4} and the fraction
of K*(892)^0 mesons that are longitudinally polarized f_L=
44.8(+4.0-2.7)(+4.0-5.3)%. These results are obtained from a 605fb^{-1} data
sample that contains 657 million B-anti-B pairs collected near the Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric energy e+e- collider.Comment: Final version published in PRD(RC
Observation of Two Resonant Structures in e+e- to pi+ pi- psi(2S) via Initial State Radiation at Belle
The cross section for e+e- to pi+ pi- psi(2S) between threshold and
\sqrt{s}=5.5 GeV is measured using 673 fb^{-1} of data on and off the
\Upsilon(4S) resonance collected with the Belle detector at KEKB. Two resonant
structures are observed in the pi+ pi- psi(2S) invariant mass distribution, one
at 4361\pm 9\pm 9 MeV/c2 with a width of 74\pm 15\pm 10 MeV/c2, and another at
4664\pm 11\pm 5 MeV/c2 with a width of 48\pm 15\pm 3 MeV/c2, if the mass
spectrum is parameterized with the coherent sum of two Breit-Wigner functions.
These values do not match those of any of the known charmonium states.Comment: 10 pages, 5 figures, 2 tables, version to appear in Phys. Rev. Let
Observation of a new D_sJ meson in B+->D0BD0K+ decays
We report the observation of a new meson produced in . This state has a mass of
, a width and a spin-parity. The results are
based on an analysis of 449 million events collected at the
resonance with the Belle detector at the KEKB asymmetric-energy
collider.Comment: submitted to Phys. Rev. Let
Improved measurement of time-dependent CP violation in B0 -> J/Psi pi0 decays
We report improved measurements of time-dependent CP violation parameters for
decay. This analysis is based on 535 million
pairs accumulated at the resonance with the Belle
detector at the KEKB asymmetric-energy e^+e^- collider. From the distribution
of proper time intervals between the two B decays, we obtain the following CP
violation parameters and , which are consistent with Standard Model
expectations.Comment: Resubmitted to PRD(RC), including 4 figures, 6pages Revision has been
made according to communication with PRD referee
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