16,490 research outputs found
Droplet traffic in microfluidic networks: A simple model for understanding and designing
We propose a simple model to analyze the traffic of droplets in microfluidic
``dual networks''. Such functional networks which consist of two types of
channels, namely those accessible or forbidden to droplets, often display a
complex behavior characteristic of dynamical systems. By focusing on three
recently proposed configurations, we offer an explanation for their remarkable
behavior. Additionally, the model allows us to predict the behavior in
different parameter regimes. A verification will clarify fundamental issues,
such as the network symmetry, the role of the driving conditions, and of the
occurrence of reversible behavior. The model lends itself to a fast numerical
implementation, thus can help designing devices, identifying parameter windows
where the behavior is sufficiently robust for a devices to be practically
useful, and exploring new functionalities.Comment: accepted for publication in PR
Sampling eigenmodes in colloidal solids
We study the properties of correlation matrices widely used in the
characterisation of vibrational modes in colloidal materials. We show that the
eigenvectors in the middle of the spectrum are strongly mixed, but that at both
the top and the bottom of the spectrum it is possible to extract a good
approximation to the true eigenmodes of an elastic system.Comment: 6 pages, 10 figure
Nucleon Form Factors of the Isovector Axial-Vector Current: Situation of Experiments and Theory
The theoretical and experimental status of the isovector axial-vector current
form factors G_A(q^2) and G_P(q^2) of the nucleon is reviewed. We also describe
a new calculation of these form factors in manifestly Lorentz-invariant chiral
perturbation theory (ChPT) with the inclusion of axial-vector mesons as
explicit degrees of freedom.Comment: 5 pages, 3 figures. Talk given by M. R. Schindler at the
International Workshop "From Parity Violation to Hadronic Structure and
more...", Milos, Greece, May 16-20, 200
CSF sTREM2: Marking the tipping point between preclinical AD and dementia?
Biomarkers for Alzheimer's disease (AD) have improved our understanding of the temporal sequence of biological events that lead to AD dementia (Jack et al, 2013). AD is characterized neuropathologically by amyloid plaques comprised of the amyloidâβ peptide and neurofibrillary tangles comprised of tau. Brain amyloid deposition, as evidenced by a decline in amyloidâβ peptide 42 (Aβ42) in the cerebrospinal fluid (CSF) or by binding of amyloid PET ligands, is thought to be a key initiating event in AD and begins many years prior to the onset of dementia. A rise in CSF tau and phosphorylated tau in the setting of Aβ deposition appears to reflect neurodegeneration and also begins years prior to the onset of dementia but after Aβ deposition has begun to accumulate. Individuals with âpreclinical AD,â that is, normal cognition but abnormal AD biomarkers, have a much higher risk for developing AD dementia but may remain cognitively normal for years (Vos et al, 2013). While deposition of amyloid and formation of tau tangles are necessary for AD to occur, it is likely that additional events involving inflammation or other processes contribute to crossing the tipping point from preclinical AD to AD dementia. Current efforts are aimed at defining the biomarker(s) that best predict the transition from cognitive normality to abnormality. A biomarker that is closely associated with the onset of cognitive decline could help us to understand the biological events that connect amyloid deposition and tangle formation to cognitive decline and could have significant practical value in AD diagnosis and clinical trial design
Is MS1054-03 an exceptional cluster? A new investigation of ROSAT/HRI X-ray data
We reanalyzed the ROSAT/HRI observation of MS1054-03, optimizing the channel
HRI selection and including a new exposure of 68 ksec. From a wavelet analysis
of the HRI image we identify the main cluster component and find evidence for
substructure in the west, which might either be a group of galaxies falling
onto the cluster or a foreground source. Our 1-D and 2-D analysis of the data
show that the cluster can be fitted well by a classical betamodel centered only
20arcsec away from the central cD galaxy. The core radius and beta values
derived from the spherical model(beta = 0.96_-0.22^+0.48) and the elliptical
model (beta = 0.73+/-0.18) are consistent. We derived the gas mass and total
mass of the cluster from the betamodel fit and the previously published ASCA
temperature (12.3^{+3.1}_{-2.2} keV). The gas mass fraction at the virial
radius is fgas = (14[-3,+2.5]+/-3)% for Omega_0=1, where the errors in brackets
come from the uncertainty on the temperature and the remaining errors from the
HRI imaging data. The gas mass fraction computed for the best fit ASCA
temperature is significantly lower than found for nearby hot clusters,
fgas=20.1pm 1.6%. This local value can be matched if the actual virial
temperature of MS1054-032 were close to the lower ASCA limit (~10keV) with an
even lower value of 8 keV giving the best agreement. Such a bias between the
virial and measured temperature could be due to the presence of shock waves in
the intracluster medium stemming from recent mergers. Another possibility, that
reconciles a high temperature with the local gas mass fraction, is the
existence of a non zero cosmological constant.Comment: 12 pages, 5 figures, accepted for publication in Ap
Infrared regularization of baryon chiral perturbation theory reformulated
We formulate the infrared regularization of Becher and Leutwyler in a form
analogous to our recently proposed extended on-mass-shell renormalization. In
our formulation, IR regularization can be applied straightforwardly to
multi-loop diagrams with an arbitrary number of particles with arbitrary
masses.Comment: 10 pages, ReVTEX 4, no figure
Brain Activation During Passive and Volitional Pedaling After Stroke
Background: Prior work indicates that pedaling-related brain activation is lower in people with stroke than in controls. We asked whether this observation could be explained by between-group differences in volitional motor commands and pedaling performance. Methods: Individuals with and without stroke performed passive and volitional pedaling while brain activation was recorded with functional magnetic resonance imaging. The passive condition eliminated motor commands to pedal and minimized between-group differences in pedaling performance. Volume, intensity, and laterality of brain activation were compared across conditions and groups. Results: There were no significant effects of condition and no GroupâĂâCondition interactions for any measure of brain activation. Only 53% of subjects could minimize muscle activity for passive pedaling. Conclusions: Altered motor commands and pedaling performance are unlikely to account for reduced pedaling-related brain activation poststroke. Instead, this phenomenon may be due to functional or structural brain changes. Passive pedaling can be difficult to achieve and may require inhibition of excitatory descending drive
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