A Comparison of Weak Lensing Measurements From Ground- and Space-Based Facilities

We assess the relative merits of weak lensing surveys, using overlapping imaging data from the ground-based Subaru telescope and the Hubble Space Telescope (HST). Our tests complement similar studies undertaken with simulated data. From observations of 230,000 matched objects in the 2 square degree COSMOS field, we identify the limit at which faint galaxy shapes can be reliably measured from the ground. Our ground-based shear catalog achieves sub-percent calibration bias compared to high resolution space-based data, for galaxies brighter than i'~24.5 and with half-light radii larger than 1.8". This selection corresponds to a surface density of ~15 galaxies per sq arcmin compared to ~71 per sq arcmin from space. On the other hand the survey speed of current ground-based facilities is much faster than that of HST, although this gain is mitigated by the increased depth of space-based imaging desirable for tomographic (3D) analyses. As an independent experiment, we also reconstruct the projected mass distribution in the COSMOS field using both data sets, and compare the derived cluster catalogs with those from X-ray observations. The ground-based catalog achieves a reasonable degree of completeness, with minimal contamination and no detected bias, for massive clusters at redshifts 0.2<z<0.5. The space-based data provide improved precision and a greater sensitivity to clusters of lower mass or at higher redshift.Comment: 12 pages, 8 figures, submitted to ApJ, Higher resolution figures available at http://www.astro.caltech.edu/~mansi/GroundvsSpace.pd

Intrinsic carrier mobility of multi-layered MoS2_2 field-effect transistors on SiO2_2

By fabricating and characterizing multi-layered MoS$_2$-based field-effect transistors (FETs) in a four terminal configuration, we demonstrate that the two terminal-configurations tend to underestimate the carrier mobility $\mu$ due to the Schottky barriers at the contacts. For a back-gated two-terminal configuration we observe mobilities as high as 125 cm$^2$V$^{-1}$s$^{-1}$ which is considerably smaller than 306.5 cm$^2$V$^{-1}$s$^{-1}$ as extracted from the same device when using a four-terminal configuration. This indicates that the intrinsic mobility of MoS$_2$ on SiO$_2$ is significantly larger than the values previously reported, and provides a quantitative method to evaluate the charge transport through the contacts.Comment: 8 pages, 5 figures, typos fixed, and references update

Optical implementation of systolic array processing

Algorithms for matrix vector multiplication are implemented using acousto-optic cells for multiplication and input data transfer and using charge coupled devices detector arrays for accumulation and output of the results. No two dimensional matrix mask is required; matrix changes are implemented electronically. A system for multiplying a 50 component nonnegative real vector by a 50 by 50 nonnegative real matrix is described. Modifications for bipolar real and complex valued processing are possible, as are extensions to matrix-matrix multiplication and multiplication of a vector by multiple matrices

Exploring barriers to 'Respondent driven sampling' in sex worker and drug-injecting sex worker populations in Eastern Europe

Respondent driven sampling (RDS) has been used in several counties to sample injecting drug users, sex workers (SWs) and men who have sex with men and as a means of collecting behavioural and biological health data. We report on the use of RDS in three separate studies conducted among SWs between 2004 and 2005 in the Russian Federation, Serbia, and Montenegro. Findings suggest that there are limitations associated with the use of RDS in SW populations in these regions. Findings highlight three main factors that merit further investigation as a means of assessing the feasibility and appropriateness of RDS in this high risk population: the network characteristics of SWs; the appropriate level of participant incentives; and lack of service contact. The highly controlled and hidden nature of SW organizations and weak SW social networks in the region can combine to undermine assumptions underpinning the feasibility of RDS approaches and potentially severely limit recruitment. We discuss the implications of these findings for recruitment and the use of monetary and non-monetary incentives in future RDS studies of SW populations in Eastern Europe

DGNB building certification companion: Sustainability Tool for Assessment, Planning, Learning, and Engaging (STAPLE)

In the construction industry, the popularity of sustainability and its benefits have been on the rise in recent years. Alas, with various building sustainability assessment schemes on the market, there is still no single general method for a comprehensive and inclusive design and building process for sustainable buildings. The literature describes several barriers of entry preventing actors in the industry from seeking sustainability certifications and prioritizing design methods, supporting sustainability in greater numbers. In the newly developed tool, “DGNB building certification companion: Sustainable Tool for Assessment, Planning, Learning, and Engaging (STAPLE)”, a new Excel-based, interactive, and iterative education focused platform is introduced, intended to engage dialog among stakeholders, building owners, and decision makers, and the assigned group team leaders, based on the five DGNB topics. In order to establish common levels of knowledge, terminology, and understanding for proper interdisciplinary discussions, which would result in suitable and timely decisions, personal and professional development is enabled by imbedded educational documents in multiple formats throughout the tool as plain-language, easily digestible summaries of various topics regarding sustainability and the DGNB certification scheme. The identified barriers are described in the tool followed by a solution to overcome them. The tool, tested at multiple stages of development and moulded by many individuals both within and outside of the sustainable building industry, has shown to achieve the primary goals of assessment of individual’s current knowledge, educating through multiple stages and formats, and the inspiring of conversation among team members through a graphical display of opinions. Based on user feedback, the conclusion was that this is a desired product on the market. This new approach is expected to dramatically reduce misunderstandings, conflicts, and mistakes during a sustainable design process, helping the design team plan a project to possibly obtain the highest DGNB score if desired and properly documented

Recent development in the design, testing and impact-damage tolerance of stiffened composite panels

Structural technology of laminated filamentary-composite stiffened-panel structures under combined inplane and lateral loadings is discussed. Attention is focused on: (1) methods for analyzing the behavior of these structures under load and for determining appropriate structural proportions for weight-efficient configurations; and (2) effects of impact damage and geometric imperfections on structural performance. Recent improvements in buckling analysis involving combined inplane compression and shear loadings and transverse shear deformations are presented. A computer code is described for proportioning or sizing laminate layers and cross-sectional dimensions, and the code is used to develop structural efficiency data for a variety of configurations, loading conditions, and constraint conditions. Experimental data on buckling of panels under inplane compression is presented. Mechanisms of impact damage initiation and propagation are described

Updated recommendations for HER2 testing in the UK

This paper serves to update previously published guidance on rationale and methodology for HER2 laboratory testing following the recommendation for the use of HER2 targeted treatment in the management of advanced breast cancer in the UK. Emphasis is placed on the standardisation of methodology and assessment and strategies to achieve high quality performance. A two phase testing algorithm based on first line immunocytochemistry evaluation and second line fluorescence in situ hybridisation assessment of borderline cases is recommended. To ensure maintenance of expertise, an annual caseload volume of at least 250 cases is recommended for laboratories providing a testing service

The analysis of solar models: Neutrinos and oscillations

Tests of solar neutrino flux and solar oscillation frequencies were used to assess standard stellar structure theory. Standard and non-standard solar models are enumerated and discussed. The field of solar seismology, wherein the solar interior is studied from the measurement of solar oscillations, is introduced

Fungal genomics in respiratory medicine: what, how and when?

Respiratory infections caused by fungal pathogens present a growing global healthconcern and are a major cause of death in immunocompromised patients. Worryingly,coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome,has been shown to predispose some patients to fungal co-infection and secondarypulmonary aspergillosis. Aspergillosis is most commonly caused by the fungalpathogen Aspergillus fumigatus and primarily treated using the triazole drug group,however in recent years, this fungus has been rapidly gaining resistance against theseantifungals. This is of serious clinical concern as multi-azole resistant forms ofaspergillosis have a higher risk of mortality when compared against azole-susceptibleinfections. With the increasing numbers of COVID-19 and other classes ofimmunocompromised patients, early diagnosis of fungal infections is critical to ensuringpatient survival. However, time-limited diagnosis is difficult to achieve with currentculture-based methods. Advances within fungal genomics have enabled moleculardiagnostic methods to become a fast, reproducible, and cost-effective alternative fordiagnosis of respiratory fungal pathogens and detection of antifungal resistance. Herewe describe what techniques are currently available within molecular diagnostics, howthey work and when they have been used

Editors' Choice-Review-Exploration of Computational Approaches for Understanding Microbial Electrochemical Systems: Opportunities and Future Directions

Microbial electrochemical systems offer valuable opportunities in the field of electrochemistry for a wide range of applications and fundamental insights. Applications include renewable power generation, electrosynthesis, and sensing, and provide a critical platform for understanding fundamental electrochemical processes between biotic and abiotic components. However, despite several research efforts, the fundamental electron transfer mechanisms inherent to microbial bioelectrochemical systems remain poorly understood, limiting their full potential and applications. This lack of fundamental understanding stems from both the conceptual and experimental complexity of microbial electrochemical systems. In this context, the possibility of multi-disciplinary research utilizing computational methods provides a powerful tool for this field. Herein, we critically review how computational studies and methods employed to study microbial electrochemical systems in multiple dimensions can be used to clarify the different factors governing microbial electrochemical systems. This discussion addresses how the combination of various techniques can enhance fundamental understanding, providing scientists with tools for the rational design of improved systems and opening exciting new research opportunities