18,580 research outputs found
Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement
Breaking Kelvin: Circulation conservation and vortex breakup in MHD at low Magnetic Prandtl Number
In this paper we examine the role of weak magnetic fields in breaking
Kelvin's circulation theorem and in vortex breakup in two-dimensional
magnetohydrodynamics for the physically important case of a low magnetic
Prandtl number (low ) fluid. We consider three canonical inviscid solutions
for the purely hydrodynamical problem, namely a Gaussian vortex, a circular
vortex patch and an elliptical vortex patch. We examine how magnetic fields
lead to an initial loss of circulation and attempt to derive scaling
laws for the loss of circulation as a function of field strength and diffusion
as measured by two non-dimensional parameters. We show that for all cases the
loss of circulation depends on the integrated effects of the Lorentz force,
with the patch cases leading to significantly greater circulation loss. For the
case of the elliptical vortex the loss of circulation depends on the total area
swept out by the rotating vortex and so this leads to more efficient
circulation loss than for a circular vortex.Comment: 21 pages, 12 figure
Stabilization, pointing and command control of a balloon-borne 1-meter telescope
A 1-meter balloon-borne telescope has been constructed and flown to observe far-infrared radiation from celestial sources. The attitude control systems must perform to the diffraction limit of the telescope for stabilization and have positioning capability for source acquisition. These and associated systems are discussed in detail, as is the command control of the payload as a whole
Interferon regulatory factor 1 protects against chikungunya virus-induced immunopathology by restricting infection in muscle cells
Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques
Classifying continuous, real-time e-nose sensor data using a bio-inspired spiking network modelled on the insect olfactory system
In many application domains, conventional e-noses are frequently outperformed in both speed and accuracy by their biological counterparts. Exploring potential bio-inspired improvements, we note a number of neuronal network models have demonstrated some success in classifying static datasets by abstracting the insect olfactory system. However, these designs remain largely unproven in practical
settings, where sensor data is real-time, continuous, potentially noisy, lacks a precise onset signal and
accurate classification requires the inclusion of temporal aspects into the feature set. This investigation
therefore seeks to inform and develop the potential and suitability of biomimetic classifiers for use with typical real-world sensor data. Taking a generic classifier design inspired by the inhibition and
competition in the insect antennal lobe, we apply it to identifying 20 individual chemical odours from
the timeseries of responses of metal oxide sensors. We show that four out of twelve available sensors
and the first 30 s(10%) of the sensors’ continuous response are sufficient to deliver 92% accurate
classification without access to an odour onset signal. In contrast to previous approaches, once
training is complete, sensor signals can be fed continuously into the classifier without requiring
discretization. We conclude that for continuous data there may be a conceptual advantage in using
spiking networks, in particular where time is an essential component of computation. Classification
was achieved in real time using a GPU-accelerated spiking neural network simulator developed in our
group
Polarization morphology of SiO masers in the circumstellar envelope of the AGB star R Cassiopeiae
Silicon monoxide maser emission has been detected in the circumstellar
envelopes of many evolved stars in various vibrationally-excited rotational
transitions. It is considered a good tracer of the wind dynamics close to the
photosphere of the star. We have investigated the polarization morphology in
the circumstellar envelope of an AGB star, R Cas. We mapped the linear and
circular polarization of SiO masers in the v=1, J=1-0 transition. The linear
polarization is typically a few tens of percent while the circular polarization
is a few percent. The fractional polarization tends to be higher for emission
of lower total intensity. We found that, in some isolated features the
fractional linear polarization appears to exceed 100%. We found the Faraday
rotation is not negligible but is ~15 deg., which could produce small scale
structure in polarized emission whilst total intensity is smoother and partly
resolved out. The polarization angles vary considerably from feature to feature
but there is a tendency to favour the directions parallel or perpendicular to
the radial direction with respect to the star. In some features, the
polarization angle abruptly flips 90 deg. We found that our data are in the
regime where the model of Goldreich et al (1973) can be applied and the
polarization angle flip is caused when the magnetic field is at close to 55
deg. to the line of sight. The polarization angle configuration is consistent
with a radial magnetic field although other configurations are not excluded.Comment: 14 pages, 15 figures. Accepted for publication in MNRA
The opposites task: Using general rules to test cognitive flexibility in preschoolers
A brief narrative description of the journal article, document, or resource. Executive functions play an important role in cognitive development, and during the preschool years especially, children's performance is limited in tasks that demand flexibility in their behavior. We asked whether preschoolers would exhibit limitations when they are required to apply a general rule in the context of novel stimuli on every trial (the "opposites" task). Two types of inhibitory processing were measured: response interference (resistance to interference from a competing response) and proactive interference (resistance to interference from a previously relevant rule). Group data show 3-year-olds have difficulty inhibiting prepotent tendencies under these conditions, whereas 5-year-olds' accuracy is near ceiling in the task. (Contains 4 footnotes and 1 table.
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