Teoría del método dialéctico

libro -- Universidad de Costa Rica. Sede de San Ramón, 1981Consiste en una selección de materiales sobre algunos aspectos de la teoría del método dialéctico y presenta un conjunto de ensayos, artículos y trabajos importantes para la comprensión, aplicación y desarrollo del método dialéctico. Sus a autores pertenecen a diferentes épocas y circunstancias socio históricas.Universidad de Costa RicaUCR::Sedes Regionales::Sede de Occident

Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome

Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term survival after lung transplantation. Identifying predictors of BOS is essential to prevent the progression of dysfunction before irreversible damage occurs. By using a large set of 107 samples from lung recipients, we performed microarray gene expression profiling of whole blood to identify early biomarkers of BOS, including samples from 49 patients with stable function for at least 3 years, 32 samples collected at least 6 months before BOS diagnosis (prediction group), and 26 samples at or after BOS diagnosis (diagnosis group). An independent set from 25 lung recipients was used for validation by quantitative PCR (13 stables, 11 in the prediction group, and 8 in the diagnosis group). We identified 50 transcripts differentially expressed between stable and BOS recipients. Three genes, namely POU class 2 associating factor 1 (POU2AF1), T-cell leukemia/lymphoma protein 1A (TCL1A), and B cell lymphocyte kinase, were validated as predictive biomarkers of BOS more than 6 months before diagnosis, with areas under the curve of 0.83, 0.77, and 0.78 respectively. These genes allow stratification based on BOS risk (log-rank test p < 0.01) and are not associated with time posttransplantation. This is the first published large-scale gene expression analysis of blood after lung transplantation. The three-gene blood signature could provide clinicians with new tools to improve follow-up and adapt treatment of patients likely to develop BOS

REXS contribution to electronic ordering investigation in solids

Resonant Elastic X-Ray Scattering (REXS) has played a fundamental role in understanding electronic properties and in revealing hidden order, local symmetries and exotic states realized in correlated solids. This article reports on some of the relevant scientific contributions and technical advances over the last 20 years, by providing a list of related publications produced by various groups all around the world. The given perspective is that of a group of young scientists involved at various times in the investigation of the beauty of electronic ordering by the REXS technique. © 2012 EDP Sciences, Springer-Verlag