1,594 research outputs found
Effects of Raney-type Nickel Catalyst Production Scale Pretreatment
The need for optimizing chemical production processes in pharmaceutical industry by taking economic issues into account has increased more than ever before. This work deals with the hydrogenation of TLP (N-3-fluor-acethyl-L-lisil-L-proline) over
Raney-type Nickel catalysts for the production of an active pharmaceutical ingredient (API) and presents two specific findings at a production site, which influence the overall performance of the process. It is shown that the Raney-type Nickel catalyst pretreatment
and the impurities present in the reactants have a large impact on the catalyst surface activity.
Both considerably affect the number of cycles a batch of catalyst can be reused, which can obviously lead to increased cost efficiency
Response to Kuhse
In this short paper, we respond to critics of our original paper, The agony of agonal respiration: is the
last gasp necessary?. A common thread in both Hawryluckâ s and Kuhseâ s responses is the difficulties
encountered when using the agentâ s intentions to make moral distinctions between using neuromuscular
blocking drugs to palliate versus using neuromuscular blocking drugs to kill. Although this difficulty does
exist we maintain that the intentions of the physician must matter when providing end-of-life care. Originally published Journal of Medical Ethics, Vol. 28, No. 4, Aug. 200
Metal silicide/poly-Si Schottky diodes for uncooled microbolometers
Nickel silicide Schottky diodes formed on polycrystalline Si films are
proposed as temperature sensors of monolithic uncooled microbolometer IR focal
plane arrays. Structure and composition of nickel silicide/polycrystalline
silicon films synthesized in a low-temperature process are examined by means of
transmission electron microscopy. The Ni silicide is identified as multi-phase
compound composed by 20 to 40% of Ni3Si, 30 to 60% of Ni2Si and 10 to 30% of
NiSi with probable minor content of NiSi2 at the silicide/poly-Si interface.
Rectification ratios of the Schottky diodes vary from ~100 to ~20 for the
temperature increasing from 22 to 70C; they exceed 1000 at 80K. A barrier of
~0.95 eV is found to control the photovoltage spectra at room temperature. A
set of barriers is observed in photo-emf spectra at 80K and attributed to the
Ni-silicide/poly-Si interface. Absolute values of temperature coefficients of
voltage and current are found to vary from 0.3 to 0.6%/K for forward biasing
and around 2.5%/K for reverse biasing of the diodes.Comment: 18 pages, 7 figure
Occurrence of fungicide residues on Argentinean blueberry fruit and juice samples
Azoxystrobin, boscalid, cyprodinil, fludioxonil and pyraclostrobin are fungicides commonly used in Argentina against different fungus contaminations in the blueberry field. The presence of these fungicides was investigated in 50 samples of blueberry fruit and 15 samples of blueberry juice purchased in Argentina. Fungicide residues were determined by solid-phase microextraction (SPME) coupled to gas chromatography with micro-electron capture and nitrogen phosphorous detector. The average concentrations of azoxystrobin were 48 ug/kg in blueberry fruit. Average of boscalid were 43 and 239 ug/kg, of cyprodinil 1581 and 852 ug/kg, of fludioxonil 1077 and 2842 g/kg, and of pyraclostrobin 578 and 3414 ug/kg, in fruits and juice respectively. The higher concentrations of fungicides were found in those cases where the time between the application of the compound and the fruit’s commercialization was shorter than the fungicide’s half-life.Fil: Munitz, Martín Sebastián. Universidad Nacional de Entre Ríos. Facultad de Ciencias de la Alimentación; ArgentinaFil: Resnik, Silvia Liliana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Montti, M.. Universidad Nacional de Entre Ríos. Facultad de Ciencias de la Alimentación; ArgentinaFil: Medina, María Belén. Universidad Nacional de Entre Ríos. Facultad de Ciencias de la Alimentación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Can metaphysical structuralism solve the plurality problem?
Metaphysics has a problem with plurality: in many areas of discourse, there are too many good theories, rather than just one. This embarrassment of riches is a particular problem for metaphysical realists who want metaphysics to tell us the way the world is and for whom one theory is the correct one. A recent suggestion is that we can treat the different theories as being functionally or explanatorily equivalent to each other, even though they differ in content. The aim of this paper is to explore whether the notion of functionally equivalent theories can be extended and utilized in the defence of metaphysical realism, drawing upon themes from structuralism in the philosophies of mathematics and science in which the specifics of theories do not matter as long as the relations in which they stand to other theories are maintained. I argue that despite its initial attractiveness, there are significant difficulties with this proposal. Discovering these obstacles (most probably) thwarts the realist structuralist project, but reveals interesting features of metaphysical systems
Bilateral symmetrical cortical osteolytic lesions in two patients with Gaucher disease
Gaucher disease (GD) is an autosomal recessive
lysosomal storage disorder characterized by the reduced or
absent activity of glucocerebrosidase. The disease is split
into three types. Type 3, or chronic neuronopathic GD,
manifests with heterogeneous clinical presentations. Skeletal
manifestations of GD can include abnormal bone
remodeling resulting in the characteristic Erlenmeyer flask
deformities, painful bone crises, osteopenia, and an increased
frequency of fractures. Osteolytic lesions can also
occur but are rare and tend to be large, expanding
intramedullary lesions with cortical thinning. We present
two adolescent patients with type 3 GD who developed
bilateral symmetrical cortical osteolytic lesions. The lesions
in both cases demonstrate predominant cortical scalloping
with fairly indolent growth. Neither patient manifests some
of the more common bony manifestations of GD—bone
crises or osteonecrosis. These atypical and unique skeletal findings in two unrelated probands with type 3 GD further
expand the extent of phenotypic variation encountered in
this single gene disorder
Telephone and face to face methods of assessment of veteran's community reintegration yield equivalent results
<p>Abstract</p> <p>Background</p> <p>The Community Reintegration of Service Members (CRIS) is a new measure of community reintegration developed to measure veteran's participation in life roles. It consists of three sub-scales: Extent of Participation (Extent), Perceived Limitations with Participation (Perceived), and Satisfaction with Participation (Satisfaction). Testing of the CRIS measure to date has utilized in-person administration. Administration of the CRIS measure by telephone, if equivalent to in-person administration, would be desirable to lower cost and decrease administrative burden. The purpose of this study was to test the equivalence of telephone and in-person mode of CRIS administration.</p> <p>Methods</p> <p>A convenience sample of 102 subjects (76% male, 24% female, age mean = 49 years, standard deviation = 8.3) were randomly assigned to received either telephone interview at Visit 1 and in-person interview at Visit 2, or in-person interview at Visit 1 and telephone interview a Visit 2. Both Visits were conducted within one week. Intraclass correlation coefficients, ICC (2,1), were used to evaluate correspondence between modes for both item scores and summary scores. ANOVAs with mode order as a covariate were used to test for presence of an ordering effect.</p> <p>Results</p> <p>ICCs (95%CI) for the subscales were 0.92 (0.88-0.94) for Extent, 0.85 (0.80-0.90) for Perceived, and 0.89 (0.84-0.93) for Satisfaction. No ordering effect was observed.</p> <p>Conclusion</p> <p>Telephone administration of the CRIS measure yielded equivalent results to in-person administration. Telephone administration of the CRIS may enable lower costs of administration and greater adoption.</p
Unbroken supersymmetry in the Aharonov-Casher effect
We consider the problem of the bound states of a spin 1/2 chargless particle
in a given Aharonov-Casher configuration. To this end we recast the description
of the system in a supersymmetric form. Then the basic physical requirements
for unbroken supersymmetry are established. We comment on the possibility of
neutron confinement in this system
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