The Mars observer camera

A camera designed to operate under the extreme constraints of the Mars Observer Mission was selected by NASA in April, 1986. Contingent upon final confirmation in mid-November, the Mars Observer Camera (MOC) will begin acquiring images of the surface and atmosphere of Mars in September-October 1991. The MOC incorporates both a wide angle system for low resolution global monitoring and intermediate resolution regional targeting, and a narrow angle system for high resolution selective surveys. Camera electronics provide control of image clocking and on-board, internal editing and buffering to match whatever spacecraft data system capabilities are allocated to the experiment. The objectives of the MOC experiment follow

Titan Mare Explorer (TiME): first in situ exploration of an extraterrestrial sea

The lakes and seas of Titan are a sink of products of photolysis in the atmosphere, and a crucial component in Titan's active methane cycle. In situ exploration of the seas is necessary to understand their intriguing prebiotic organic chemistry

Mars Observer Camera

The Mars Observer camera (MOC) is a three-component system (one narrow-angle and two wide-angle cameras) designed to take high spatial resolution pictures of the surface of Mars and to obtain lower spatial resolution, synoptic coverage of the planet's surface and atmosphere. The cameras are based on the “push broom” technique; that is, they do not take “frames” but rather build pictures, one line at a time, as the spacecraft moves around the planet in its orbit. MOC is primarily a telescope for taking extremely high resolution pictures of selected locations on Mars. Using the narrow-angle camera, areas ranging from 2.8 km × 2.8 km to 2.8 km × 25.2 km (depending on available internal digital buffer memory) can be photographed at about 1.4 m/pixel. Additionally, lower-resolution pictures (to a lowest resolution of about 11 m/pixel) can be acquired by pixel averaging; these images can be much longer, ranging up to 2.8 × 500 km at 11 m/pixel. High-resolution data will be used to study sediments and sedimentary processes, polar processes and deposits, volcanism, and other geologic/geomorphic processes. The MOC wide-angle cameras are capable of viewing Mars from horizon to horizon and are designed for low-resolution global and intermediate resolution regional studies. Low-resolution observations can be made every orbit, so that in a single 24-hour period a complete global picture of the planet can be assembled at a resolution of at least 7.5 km/pixel. Regional areas (covering hundreds of kilometers on a side) may be photographed at a resolution of better than 250 m/pixel at the nadir. Such images will be particularly useful in studying time-variable features such as lee clouds, the polar cap edge, and wind streaks, as well as acquiring stereoscopic coverage of areas of geological interest. The limb can be imaged at a vertical and along-track resolution of better than 1.5 km. Different color filters within the two wide-angle cameras permit color images of the surface and atmosphere to be made to distinguish between clouds and the ground and between clouds of different composition

Mars Observer Camera

The Mars Observer camera (MOC) is a three-component system (one narrow-angle and two wide-angle cameras) designed to take high spatial resolution pictures of the surface of Mars and to obtain lower spatial resolution, synoptic coverage of the planet's surface and atmosphere. The cameras are based on the “push broom” technique; that is, they do not take “frames” but rather build pictures, one line at a time, as the spacecraft moves around the planet in its orbit. MOC is primarily a telescope for taking extremely high resolution pictures of selected locations on Mars. Using the narrow-angle camera, areas ranging from 2.8 km × 2.8 km to 2.8 km × 25.2 km (depending on available internal digital buffer memory) can be photographed at about 1.4 m/pixel. Additionally, lower-resolution pictures (to a lowest resolution of about 11 m/pixel) can be acquired by pixel averaging; these images can be much longer, ranging up to 2.8 × 500 km at 11 m/pixel. High-resolution data will be used to study sediments and sedimentary processes, polar processes and deposits, volcanism, and other geologic/geomorphic processes. The MOC wide-angle cameras are capable of viewing Mars from horizon to horizon and are designed for low-resolution global and intermediate resolution regional studies. Low-resolution observations can be made every orbit, so that in a single 24-hour period a complete global picture of the planet can be assembled at a resolution of at least 7.5 km/pixel. Regional areas (covering hundreds of kilometers on a side) may be photographed at a resolution of better than 250 m/pixel at the nadir. Such images will be particularly useful in studying time-variable features such as lee clouds, the polar cap edge, and wind streaks, as well as acquiring stereoscopic coverage of areas of geological interest. The limb can be imaged at a vertical and along-track resolution of better than 1.5 km. Different color filters within the two wide-angle cameras permit color images of the surface and atmosphere to be made to distinguish between clouds and the ground and between clouds of different composition

HFE mutations, iron deficiency and overload in 10 500 blood donors

People with genetic haemochromatosis (GH) accumulate iron from excessive dietary absorption. In populations of northern European origin, over 90% of patients are homozygous for the C282Y mutation of the HFE gene. While about 1 in 200 people in the general population have this genotype the proportion who develop clinical haemochromatosis is not known. The influence of HFE genotype on iron status was investigated in 10 556 blood donors. The allele frequencies of the C282Y and H63D mutations were

The Mars 2020 Perseverance Rover Mast Camera Zoom (Mastcam-Z) Multispectral, Stereoscopic Imaging Investigation

Mastcam-Z is a multispectral, stereoscopic imaging investigation on the Mars 2020 mission's Perseverance rover. Mastcam-Z consists of a pair of focusable, 4:1 zoomable cameras that provide broadband red/green/blue and narrowband 400-1000 nm color imaging with fields of view from 25.6 degrees x19.2 degrees (26 mm focal length at 283 mu rad/pixel) to 6.2 degrees x4.6 degrees (110 mm focal length at 67.4 mu rad/pixel). The cameras can resolve (>= 5 pixels) similar to 0.7 mm features at 2 m and similar to 3.3 cm features at 100 m distance. Mastcam-Z shares significant heritage with the Mastcam instruments on the Mars Science Laboratory Curiosity rover. Each Mastcam-Z camera consists of zoom, focus, and filter wheel mechanisms and a 1648x1214 pixel charge-coupled device detector and electronics. The two Mastcam-Z cameras are mounted with a 24.4 cm stereo baseline and 2.3 degrees total toe-in on a camera plate similar to 2 m above the surface on the rover's Remote Sensing Mast, which provides azimuth and elevation actuation. A separate digital electronics assembly inside the rover provides power, data processing and storage, and the interface to the rover computer. Primary and secondary Mastcam-Z calibration targets mounted on the rover top deck enable tactical reflectance calibration. Mastcam-Z multispectral, stereo, and panoramic images will be used to provide detailed morphology, topography, and geologic context along the rover's traverse; constrain mineralogic, photometric, and physical properties of surface materials; monitor and characterize atmospheric and astronomical phenomena; and document the rover's sample extraction and caching locations. Mastcam-Z images will also provide key engineering information to support sample selection and other rover driving and tool/instrument operations decisions

Gold nanoparticles as catalysts for low-temperature WGS reaction

OBJECTIVES: This study aimed to compare the phenotype of Rett syndrome cases with C-terminal deletions to that of cases with different MECP2 mutations and to examine the phenotypic variation within C-terminal deletions. METHODS: Cases were selected from InterRett, an international database and from the population-based Australian Rett Syndrome Database. Cases (n=832) were included if they had a pathogenic MECP2 mutation in which the nature of the amino acid change was known. Three severity scale systems were used, and individual aspects of the phenotype were also compared. RESULTS: Lower severity was associated with C-terminal deletions (n=79) compared to all other MECP2 mutations (e.g. Pineda scale C-terminals mean 15.0 (95% CI 14.0–16.0) vs 16.2 (15.9–16.5). Cases with C-terminal deletions were more likely to have a normal head circumference (odds ratio 3.22, 95% CI 1.53 – 6.79) and weight (odds ratio 2.97, 95% CI 1.25–5.76). Onset of stereotypies tended to be later (median age 2.5 years vs 2 years, p<0.001 from survival analysis), and age of learning to walk tended to be earlier (median age 1.6 years vs 2 years, p=0.002 from survival analysis). Those with C-terminal deletions occurring later in the region had lower average severity scores than those occurring earlier in the region. CONCLUSION: In terms of overall severity C-terminal deletion cases would appear to be in the middle of the range. In terms of individual aspects of phenotype growth and ability to ambulate appear to be particular strengths. By pooling data internationally this study has achieved the case numbers to provide a phenotypic profile of C-terminal deletions in Rett syndrome