7,911 research outputs found
Nanoparticle transport in saturated porous medium using magnetic resonance imaging
Transport study of nanoparticle (NP) through matrix flow dominated aquifer sand and soils have significant influence in natural systems. To quantify the transport behaviour, magnetic resonance imaging (MRI) was used to image the iron oxide based nanoparticle, Molday ION (carboxyl terminated) through saturated sandstone rock core. T2-weighted images were acquired and the changes in image intensity were calibrated to get a quantitative concentration profiles at various time intervals. These profiles were evaluated through CXTFIT transport model to estimate the transport parameters. These parameters are estimated at various points along the length of the column while classical breakthrough curve analysis cannot provide these details. NPâsurface interactions were investigated using DLVO (DerjaguinâLandauâVerweyâOverbeek) theory. The dispersion coefficients (2.55â1.21Â ĂÂ 10â7Â m2/s) were found to be decrease with distance, deposition rate constant k (6.70â9.13Â ĂÂ 10â4Â (1/s)) and fast deposition rate constant kfast (4.32â8.79Â ĂÂ 10â2Â (1/s)) were found to be increase with distance. These parameter variations over length will have a scaling up impact in developing transport models for environmental remediation and risk assessment schemes
The Internal Spin Angular Momentum of an Asymptotically Flat Spacetime
In this paper we investigate the manner in which the internal spin angular
momentum of a spinor field is encoded in the gravitational field at asymptotic
infinity. The inclusion of internal spin requires us to re-analyze our notion
of asymptotic flatness. In particular, the Poincar\'{e} symmetry at asymptotic
infinity must replaced by a spin-enlarged Poincar\'{e} symmetry. Likewise, the
generators of the asymptotic symmetry group must be supplemented to account for
the internal spin. In the Hamiltonian framework of first order Einstein-Cartan
gravity, the extra generator comes from the boundary term of the Gauss
constraint in the asymptotically flat context. With the additional term, we
establish the relations among the Noether charges of a Dirac field, the Komar
integral, and the asymptotic ADM-like geometric integral. We show that by
imposing mild restraints on the generating functionals of gauge transformations
at asymptotic infinity, the phase space is rendered explicitly finite. We
construct the energy-momentum and the new total (spin+orbital) angular momentum
boundary integrals that satisfy the appropriate algebra to be the generators of
the spin-enlarged Poincar\'{e} symmetry. This demonstrates that the internal
spin is encoded in the tetrad at asymptotic infinity. In addition, we find that
a new conserved and (spin-enlarged) Poincar\'{e} invariant charge emerges that
is associated with the global structure of a gauge transformation.Comment: V2: No major changes, journal reference adde
Metagenomic sequencing unravels gene fragments with phylogenetic signatures of O2-tolerant NiFe membrane-bound hydrogenases in lacustrine sediment
Many promising hydrogen technologies utilising hydrogenase enzymes have been slowed by the fact that most hydrogenases are extremely sensitive to O2. Within the group 1 membrane-bound NiFe hydrogenase, naturally occurring tolerant enzymes do exist, and O2 tolerance has been largely attributed to changes in ironâsulphur clusters coordinated by different numbers of cysteine residues in the enzymeâs small subunit. Indeed, previous work has provided a robust phylogenetic signature of O2 tolerance [1], which when combined with new sequencing technologies makes bio prospecting in nature a far more viable endeavour. However, making sense of such a vast diversity is still challenging and could be simplified if known species with O2-tolerant enzymes were annotated with information on metabolism and natural environments. Here, we utilised a bioinformatics approach to compare O2-tolerant and sensitive membrane-bound NiFe hydrogenases from 177 bacterial species with fully sequenced genomes for differences in their taxonomy, O2 requirements, and natural environment. Following this, we interrogated a metagenome from lacustrine surface sediment for novel hydrogenases via high-throughput shotgun DNA sequencing using the Illuminaâą MiSeq platform. We found 44 new NiFe group 1 membrane-bound hydrogenase sequence fragments, five of which segregated with the tolerant group on the phylogenetic tree of the enzymeâs small subunit, and four with the large subunit, indicating de novo O2-tolerant protein sequences that could help engineer more efficient hydrogenases
Force and energy dissipation variations in non-contact atomic force spectroscopy on composite carbon nanotube systems
UHV dynamic force and energy dissipation spectroscopy in non-contact atomic
force microscopy were used to probe specific interactions with composite
systems formed by encapsulating inorganic compounds inside single-walled carbon
nanotubes. It is found that forces due to nano-scale van der Waals interaction
can be made to decrease by combining an Ag core and a carbon nanotube shell in
the Ag@SWNT system. This specific behaviour was attributed to a significantly
different effective dielectric function compared to the individual
constituents, evaluated using a simple core-shell optical model. Energy
dissipation measurements showed that by filling dissipation increases,
explained here by softening of C-C bonds resulting in a more deformable
nanotube cage. Thus, filled and unfilled nanotubes can be discriminated based
on force and dissipation measurements. These findings have two different
implications for potential applications: tuning the effective optical
properties and tuning the interaction force for molecular absorption by
appropriately choosing the filling with respect to the nanotube.Comment: 22 pages, 6 figure
Stringent Phenomenological Investigation into Heterotic String Optical Unification
For the weakly coupled heterotic string (WCHS) there is a well-known factor
of twenty conflict between the minimum string coupling unification scale,
Lambda_H ~5x10^(17) GeV, and the projected MSSM unification scale, Lambda_U ~
2.5x10^(16) GeV, assuming an intermediate scale desert (ISD). Renormalization
effects of intermediate scale MSSM-charged exotics (ISME) (endemic to
quasi-realistic string models) can resolve this issue, pushing the MSSM scale
up to the string scale. However, for a generic string model, this implies that
the projected Lambda_U unification under ISD is accidental. If the true
unification scale is 5.0x10^(17) GeV, is it possible that illusionary
unification at 2.5x10^(17) GeV in the ISD scenario is not accidental? If it is
not, then under what conditions would the assumption of ISME in a WCHS model
imply apparent unification at Lambda_U when ISD is falsely assumed? Geidt's
"optical unification" suggests that Lambda_U is not accidental, by offering a
mechanism whereby a generic MSSM scale Lambda_U < Lambda_H is guaranteed. A
WCHS model was constructed that offers the possibility of optical unification,
depending on the availability of anomaly-cancelling flat directions meeting
certain requirements. This paper reports on the systematic investigation of the
optical unification properties of the set of stringent flat directions of this
model. Stringent flat directions can be guaranteed to be F-flat to all finite
order (or to at least a given finite order consistent with electroweak scale
supersymmetry breaking) and can be viewed as the likely roots of more general
flat directions. Analysis of the phenomenology of stringent flat directions
gives an indication of the remaining optical unification phenomenology that
must be garnered by flat directions developed from them.Comment: standard latex, 18 pages of tex
Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.
BACKGROUND: Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. There is variation in the recommended timing and extent of surgery in the overall treatment regimens of people with these cancers. OBJECTIVES: To determine which surgical treatment modalities for oral cavity and oropharyngeal cancers result in increased overall survival, disease free survival, progression free survival and reduced recurrence. SEARCH STRATEGY: The following electronic databases were searched: the Cochrane Oral Health Group Trials Register (to 17 February 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 1), MEDLINE via OVID (1950 to 17 February 2011) and EMBASE via OVID (1980 to 17 February 2011). There were no restrictions regarding language or date of publication. SELECTION CRITERIA: Randomised controlled trials where more than 50% of participants had primary tumours of the oral cavity or oropharynx, and which compared two or more surgical treatment modalities or surgery versus other treatment modalities. DATA COLLECTION AND ANALYSIS: Data extraction and assessment of risk of bias was undertaken independently by two or more review authors. Study authors were contacted for additional information as required. Adverse events data were collected from published trials. MAIN RESULTS: Seven trials (n = 669; 667 with cancers of the oral cavity) satisfied the inclusion criteria, but none were assessed as low risk of bias. Trials were grouped into three main comparisons. Four trials compared elective neck dissection (ND) with therapeutic neck dissection in patients with oral cavity cancer and clinically negative neck nodes, but differences in type of surgery and duration of follow-up made meta-analysis inappropriate. Three of these trials reported overall and disease free survival. One trial showed a benefit for elective supraomohyoid neck dissection compared to therapeutic ND in overall and disease free survival. Two trials found no difference between elective radical ND and therapeutic ND for the outcomes of overall survival and disease free survival. All four trials found reduced locoregional recurrence following elective ND.A further two trials compared elective radical ND with elective selective ND and found no difference in overall survival, disease free survival or recurrence. The final trial compared surgery plus radiotherapy to radiotherapy alone but data were unreliable because the trial stopped early and there were multiple protocol violations.None of the trials reported quality of life as an outcome. Two trials, evaluating different comparisons reported adverse effects of treatment. AUTHORS' CONCLUSIONS: Seven included trials evaluated neck dissection surgery in patients with oral cavity cancers. The review found weak evidence that elective neck dissection of clinically negative neck nodes at the time of removal of the primary tumour results in reduced locoregional recurrence, but there is insufficient evidence to conclude that elective neck dissection increases overall survival or disease free survival compared to therapeutic neck dissection. There is very weak evidence from one trial that elective supraomohyoid neck dissection may be associated with increased overall and disease free survival. There is no evidence that radical neck dissection increases overall survival compared to conservative neck dissection surgery. Reporting of adverse events in all trials was poor and it was not possible to compare the quality of life of patients undergoing different surgeries
CE-30 - Toward a Trapped Particle Target
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
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