A process chain for integrating microfluidic interconnection elements by micro- overmoulding of thermoplastic elastomers

This paper presents a process chain for in-line integration of microfluidic interconnection elements by a variant of micro-injection moulding (mu IM). A SEBS-based thermoplastic elastomer (TPE) was moulded over polymethylmethacrylate (PMMA) to produce a hybrid microfluidic structure with an aspect ratio of 2. The process chain implemented micro-milling for fabricating micro-structured tool inserts, and mu IM and micro-overmoulding was used for replication. A two-plate mould was used for moulding the substrate, whilst a three-plate mould with a replaceable insert was used for TPE overmoulding. The presented application was an interconnect system for a microfluidic device, which enabled direct fitting of standard tubes into microfluidic substrates. A leakage test showed that the interconnection was leak-proof within a range of flow rates between 0.32 and 0.62 ml min(-1)

High-energy Astrophysics and the Virtual Observatory

The Virtual Observatory (VO) will revolutionise the way we do Astronomy by allowing easy access to all astronomical data and by making the handling and analysis of datasets at various locations across the globe much simpler and faster. I report here on the need for the VO and its status in Europe, concentrating on the recently started EURO-VO project, and then give two specific applications of VO tools to high-energy astrophysics.Comment: 12 pages, 3 figures, invited talk at the Workshop ``Multifrequency Behaviour of High Energy Cosmic Sources'', Vulcano, Italy, May 2005, F. Giovannelli et al., in pres

Creating movable interfaces by micro-powder injection moulding

This paper presents a novel in situ technique to produce articulated components with high-precision, micro-scale movable interfaces by micro-powder injection moulding (μPIM). The presented process route is based on the use of micro-scale sacrificial layer between the movable subcomponents which is eliminated during the debinding step, creating a dimensionally-controlled, micro-scale mobile interface. The fabrication technique combines the advantages of micro-powder overmoulding, catalytic debinding and sintering. The demonstrated example was a finger bone prosthesis joint consisting of two sub-components with an interface between components of 200 μm in size. The geometries of the sub-components were designed such that they are inseparable throughout the process whilst allowing them to move relative to each other after the debinding stage. The components produced showed the feasibility of the process route to produce readily-assembled meso-, and potentially micro-, scale articulated system

AX J0049.4-7323 - a close look at a neutron star interacting with a circumstellar disk

Detailed evidence on the system AX J0049.4-7323 is presented here to show how the passage of the neutron star in the binary system disrupts the circumstellar disk of the mass donor Be star. A similar effect is noted in three other Be/X-ray binary systems. Together the observational data should provide valuable tools for modelling these complex interactions.Comment: 4 pages, accepted for publication in MNRA

Flatness optimization of micro-injection moulded parts: The case of a PMMA microfluidic component

Micro-injection moulding (µ-IM) has attracted a lot of interest because of its potential for the production of low-cost, miniaturized parts in high-volume. Applications of this technology are, amongst others, microfluidic components for lab-on-a-chip devices and micro-optical components. In both cases, the control of the part flatness is a key aspect to maintaining the component's functionality. The objective of this work is to determine the factors affecting the flatness of a polymer part manufactured by µ-IM and to control the manufacturing process with the aim of minimizing the in-process part deformation. As a case study, a PMMA microfluidic substrate with overall dimensions of 10 mm diameter and 1 mm thickness was investigated by designing a µ-IM experiment having flatness as the experimental response. The part flatness was measured using a micro-coordinate measuring machine. Finite elements analysis was also carried out to study the optimal ejection pin configuration. The results of this work show that the control of the µ-IM process conditions can improve the flatness of the polymer part up to about 15 µm. Part flatness as low as 4 µm can be achieved by modifying the design of the ejection system according to suggested guideline

Large-Scale Bulk Motions Complicate the Hubble Diagram

We investigate the extent to which correlated distortions of the luminosity distance-redshift relation due to large-scale bulk flows limit the precision with which cosmological parameters can be measured. In particular, peculiar velocities of type 1a supernovae at low redshifts may prevent a sufficient calibration of the Hubble diagram necessary to measure the dark energy equation of state to better than 10%, and diminish the resolution of the equation of state time-derivative projected for planned surveys. We consider similar distortions of the angular-diameter distance, as well as the Hubble constant. We show that the measurement of correlations in the large-scale bulk flow at low redshifts using these distance indicators may be possible with a cumulative signal-to-noise ratio of order 7 in a survey of 300 type 1a supernovae spread over 20,000 square degrees.Comment: 6 pages; 4 figure

Design and fabrication of a three-dimensional microfluidic device for blood separation using micro-injection moulding

Micro-manufacturing is a fast developing area due to the increasing demand for components and systems of high precision and small dimensions. A number of challenges are yet to be overcome before the full potential of such techniques is realised. Examples of such challenges include limitations in component geometry, material selection and suitability for mass production. Some micro-manufacturing techniques are still at early development stages, while other techniques are at higher stage of manufacturing readiness level but require adaptation in part design or manufacturing procedure to overcome such limitations. This article presents a case study, where the design of a micro-scale, biomedical device is adapted for functionality and manufacturability by a high-volume micro-fabrication technique. Investigations are described towards a disposable three-dimensional, polymer-based device for the separation of blood cells and plasma. The importance of attempting a three-dimensional device design and fabrication route was to take advantage of the highthroughput per unit volume that such systems can, in principle, allow. The importance of a micro-moulding fabrication route was to allow such blood-containing devices to be cheaply manufactured for disposability. Initial device tests showed separation efficiency up to approximately 80% with diluted blood samples. The produced prototype indicated that the process flow was suitable for high-volume fabrication of three-dimensional microfluidics

Finding outlier light-curves in catalogs of periodic variable stars

We present a methodology to discover outliers in catalogs of periodic light-curves. We use cross-correlation as measure of ``similarity'' between two individual light-curves and then classify light-curves with lowest average ``similarity'' as outliers. We performed the analysis on catalogs of variable stars of known type from the MACHO and OGLE projects and established that our method correctly identifies light-curves that do not belong to those catalogs as outliers. We show how our method can scale to large datasets that will be available in the near future such as those anticipated from Pan-STARRS and LSST.Comment: 16 pages, 24 figure

Robust, data-driven inference in non-linear cosmostatistics

We discuss two projects in non-linear cosmostatistics applicable to very large surveys of galaxies. The first is a Bayesian reconstruction of galaxy redshifts and their number density distribution from approximate, photometric redshift data. The second focuses on cosmic voids and uses them to construct cosmic spheres that allow reconstructing the expansion history of the Universe using the Alcock-Paczynski test. In both cases we find that non-linearities enable the methods or enhance the results: non-linear gravitational evolution creates voids and our photo-z reconstruction works best in the highest density (and hence most non-linear) portions of our simulations.Comment: 14 pages, 10 figures. Talk given at "Statistical Challenges in Modern Astronomy V," held at Penn Stat

A major outburst from the X-ray binary RX J0520.5-6932

We report on the analysis of 8 years of MAssive Compact Halo Objects (MACHO) data for the source RX J0520.5-6932. A regular period of 24.4 days has been confirmed, however this is manifest almost entirely in the red part of the spectrum. A major outburst, lasting approximately 200 days, was observed which increased the apparent brightness of the object by approximately 0.15 magnitudes without significantly altering its V-R colour index. This outburst was also seen in X-ray data. The evidence from this analysis points to the identification of this object as a Be/X-ray binary with a periodically variable circumstellar disk and a very early optical counterpart.Comment: Paper has been accepted by MNRA