Revisiting digital technologies: envisioning biodigital bodies

In this paper the contemporary practices of human genomics in the 21st century are placed alongside the digital bodies of the 1990s. The primary aim is to provide a trajectory of the biodigital as follows: First, digital bodies and biodigital bodies were both part of the spectacular imaginaries of early cybercultures. Second, these spectacular digital bodies were supplemented in the mid-1990s by digital bodywork practices that have become an important dimension of everyday communication. Third, the spectacle of biodigital bodies is in the process of being supplemented by biodigital bodywork practices, through personal or direct-to-consumer genomics. This shift moves a form of biodigital communication into the everyday. Finally, what can be learned from putting the trajectories of digital and biodigital bodies together is that the degree of this communicative shift may be obscured through the doubled attachment of personal genomics to everyday digital culture and high-tech spectacle.Keywords: genomics, biodigital, bodies, spectacle, everyda

A longitudinal study of abnormalities on MRI and disability from multiple sclerosis

Background: In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of the brain increases the likelihood that multiple sclerosis will develop. We sought to determine the relation between early lesion volume, changes in volume, and long-term disability. Methods: Seventy-one patients in a serial MRI study of patients with isolated syndromes were reassessed after a mean of 14.1 years. Disability was measured with the use of Kurtzke's Expanded Disability Status Scale (EDSS; possible range, 0 to 10, with a higher score indicating a greater degree of disability). Results: Clinically definite multiple sclerosis developed in 44 of the 50 patients (88 percent) with abnormal results on MRI at presentation and in 4 of 21 patients (19 percent) with normal results on MRI. The median EDSS score at follow-up for those with multiple sclerosis was 3.25 (range, 0 to 10); 31 percent had an EDSS score of 6 or more (including three patients whose deaths were due to multiple sclerosis). The EDSS score at 14 years correlated moderately with lesion volume on MRI at 5 years (r=0.60) and with the increase in lesion volume over the first 5 years (r=0.61). Conclusions: In patients who first present with isolated syndromes suggestive of multiple sclerosis, the increases in the volume of the lesions seen on magnetic resonance imaging of the brain in the first five years correlate with the degree of long-term disability from multiple sclerosis. This relation is only moderate, so the volume of the lesions alone may not be an adequate basis for decisions about the use of disease-modifying treatment

Biodigital publics: personal genomes as digital media artifacts

The recent proliferation of personal genomics and direct-to-consumer (DTC) genomics has attracted much attention and publicity. Concern around these developments has mainly focused on issues of biomedical regulation and hinged on questions of how people understand genomic information as biomedical and what meaning they make of it. However, this publicity amplifies genome sequences which are also made as internet texts and, as such, they generate new reading publics. The practices around the generation, circulation and reading of genome scans do not just raise questions about biomedical regulation, they also provide the focus for an exploration of how contemporary public participation in genomics works. These issues around the public features of DTC genomic testing can be pursued through a close examination of the modes of one of the best known providers—23andMe. In fact, genome sequences circulate as digital artefacts and, hence, people are addressed by them. They are read as texts, annotated and written about in browsers, blogs and wikis. This activity also yields content for media coverage which addresses an indefinite public in line with Michael Warner’s conceptualisation of publics. Digital genomic texts promise empowerment, personalisation and community, but this promise may obscure the compliance and proscription associated with these forms. The kinds of interaction here can be compared to those analysed by Andrew Barry. Direct-to-consumer genetics companies are part of a network providing an infrastructure for genomic reading publics and this network can be mapped and examined to demonstrate the ways in which this formation both exacerbates inequalities and offers possibilities for participation in biodigital culture

Triple-wavelength fiber ring laser based on a hybrid gain medium actively mode-locked at 10 GHz

A fiber ring laser based on a hybrid gain medium that produces three simultaneously mode-locked wavelength channels is presented. The lithium niobate based modulator used to actively mode-lock the laser cavity at 10 GHz is birefringence compensated to reduce its polarization sensitivity. A Lyot filter defines the lasers multiwavelength spectrum which has a wavelength spacing of 1 nm. The polarization sensitive nature of the laser cavity and its affect on the performance of the laser is discussed

The prevalence of occult hepatitis B virus (hbv) infection in a large multi-ethnic haemodialysis cohort.

Haemodialysis patients are at increased risk of exposure to blood borne viruses. To reduce transmission in the UK, all haemodialysis patients are regularly screened, and if susceptible to Hepatitis B virus (HBV) infection, vaccinated

Modification of aftertaste with a menthol mouthwash reduces food wanting, liking, and ad <i>libitum </i>intake of potato crisps

This research investigated the effect of modifying the aftertaste of potato crisps on (1) temporal sensory perception and (2) appetite using three mouthwash conditions (no mouthwash, a water mouthwash, and a menthol mouthwash). For the sensory study, 17 screened female subjects were trained on the Temporal Dominance of Sensations (TDS) methodology. Subjects undertook TDS to monitor all sensory attributes during the mastication of a 2 g crisp until swallowing (at 20s), then conducted the mouthwash, and then continued the TDS task to monitor aftertaste until 90s. For the appetite study, 36 subjects (18 male, 18 female) completed 100 mm Visual Analogue Scales (VAS) for desire, liking, hunger, and thirst, followed by an ad libitum eating task. For the VAS scales testing, subjects chewed and swallowed a 2 g crisp, and then immediately conducted the mouthwash before completing the VAS scales. For the ad libitum task, subjects were given 12 min to consume as many crisps as they desired on a plate (up to 50 g). Every three minutes they were required to conduct a mouthwash. TDS results showed that in comparison with no mouthwash, the water mouthwash significantly reduced aftertaste attributes such as savoury, salty, and fatty mouthcoating, and the menthol mouthwash significantly increased aftertaste attributes of cooling, minty, and tingly. The water mouthwash did not influence desire and liking of crisps, or hunger and thirst. The water mouthwash did not influence ad libitum intake of the crisps over a 12 min period. The menthol mouthwash significantly reduced desire and liking of the crisps, as well as hunger and thirst. Furthermore, the menthol mouthwash significantly reduced ad libitum crisp intake by 29% over the 12 min period

MoviCompile : An LLVM based compiler for heterogeneous SIMD code generation

Numerous applications in communication and multimedia domains show significant data-level parallelism (DLP). The amount of DLP varies between applications in the same domain or even within a single application. Most architectures support a single vector-, SIMD-width which may not be optimal. This may cause performance and energy inefficiency. We propose the use of multiple (heterogeneous) vector-widths to better serve applications with varying DLP. The SHAVE (Streaming Hybrid Architecture Vector Engine) VLIW vector processor shown in Figure 1 is an example of such an architecture. SHAVE is a unique VLIW processor that provides hardware support for native 32-bit (short) and 128-bit (long) vector operations. Vector arithmetic unit (VAU) supports 128-bit vector arithmetic of 8/16/32-bit integer and 16/32-bit floating point types. Scalar arithmetic unit (SAU) supports 32-bit vector arithmetic of 8/16-bit integer and 16-bit floating point types. The moviCompile compiler is an LLVM based commercial compiler targeting code generation for SHAVE processor family. The moviCompile compiler is capable of SIMD code generation for 128-bit (long) and 64-bit vector operations. This work focuses on compiler backend support for 32-bit (short) vector operations. More specifically, this work aims to generate SIMD code for short vector types (e.g. 4 x i8, 2 x i16, 2 x f16) that can be executed on 32-bit SAU next to the 128/64-bit SIMD code. As a result, moviCompile is able to generate heterogeneous assembly code consisting of both short and long vector SIMD operations. Currently, we are testing the compiler using TSVC (Test Suite for Vectorizing Compilers) and intend to measure the performance improvements

An investigation into the techniques for detecting hedgehogs in a rural landscape

Various techniques and devices have been developed for the purpose of detecting wildlife but many only provide optimum results in particular habitats, for certain species or under ideal weather conditions. It is therefore advantageous to understand the efficiency and suitability of techniques under different scenarios. The effectiveness of methods for detecting rural Irish hedgehogs was investigated as part of a larger study in April 2008. Road kill sightings and questionnaires were employed to locate possible hedgehog sites. Six sites were subsequently selected, and in these areas trapping, spotlighting and foot print tunnels were employed to investigate whether hedgehogs were indeed in the surrounding landscape. Infrared thermal imagery was examined as a detection device. Trapping and infrared imagery failed to detect hedgehogs in areas where they had previously been recorded. Footprint tunnels proved to be unsuccessful in providing absolute proof of hedgehogs in an area. No single method of detection technique could be relied upon to conclude the presence of hedgehogs in an area. A combination of methods is therefore recommended. However, spotlighting was the most effective method, taking a mean of 4 nights to detect a hedgehog, in comparison to 48 nights if footprint tunnels were used as a sole method of detection. This was also suggested by rarefaction curves of these two detection techniques, where over a 48 night period hedgehogs were expected to be recorded 27 times through spotlighting and just 5 times in an equivalent period of footprint tunnel nights

Intra- and interhabitat differences in hedgehog distribution and potential prey availability

With little previous research on the European hedgehog (Erinaceus europaeus Linnaeus) in Ireland, 22 hedgehogs (16 females and six males) were tagged at a rural Irish site between June 2008 and November 2009. Transect, surveying surface invertebrates were carried out in the centre and hedgerow in arable and pasture lands distributed throughout the site. In both years, hedgehogs selected arable land and this coincided with a rise in invertebrate density. This and the fact that within the arable field hedgehogs concentrated their activity where there was a greater density of potential prey suggest that hedgehogs learn the spatial location of prospective food. Contrary to other research, in most of the hedgehogs’ home range, individuals consistently foraged in the centre of both pasture and arable lands. Potential prey was lower in fields where the hedgerow had no bramble understory, and this suggests that hedgerow with good ground cover acts as an important reserve for invertebrates. Badgers (Meles meles Linnaeus) were seen on 12 occasions within the hedgehogs’ home range and they did not appear to have a negative effect on the hedgehogs’ use of the site. It was concluded that the main factor affecting the hedgehogs’ distribution within each habitat was the availability and accessibility of potential prey