112 research outputs found
Assemblages of carabid beetles (Col. Carabidae) and ground-dwelling spiders (Araneae) in natural and artificial regeneration of pine forests
Carabid beetles and spiders are at the top of the hierarchy of general invertebrate predators, which can help to reduce the abundance of harmful forest pests. They are also frequently used as environmental indicators. In this paper we analyzed the abundance, species richness and changes in carabid beetle and spider assemblages in three treatments of pine forest regeneration â natural, natural with soil prepared by ploughing and artificial with seedlings planted in ploughed soil. The most beneficial forest regeneration treatment variant of forest regeneration for carabid beetles and spiders was the natural regeneration of pine stands without any preceding soil preparation. Both taxa responded strongly to soil ploughing. We also noted the replacement of forest species by less sensitive open area species. In carabid assemblages, large changes in the trophic structure were observed, as predatory species were replaced by hemizoophages in the ploughed treatments
hCG-secreting malignancies â diagnostic pitfalls
We present a case of a 34-year-old male patient referred to our Uro-oncology Department with a suspicion of a metastatic germ cell tumour, owing to enlarged left testicle and elevated b-hCG concentration (39 mIU/mL). Impaired performance status caused by extensive pulmonary and liver metastases, accompanied by significant lymphadenopathy, necessitated prompt management. However, a testicular tumour was excluded on ultrasound imaging; a hydrocele only was found. The b-hCG concentration was not increasing (37 mIU/mL). We found a diagnosis of an extragonadal germ cell tumour doubtful, and a liver biopsy was performed. Due to the patientâs quick deterioration, we decided to commence pre-phase chemotherapy with cisplatin and etoposide, which resulted in a significant clinical improvement. The pathological examination, along with immunoassays, revealed undifferentiated cholangiocarcinoma, and the patient continued chemotherapy with a biliary tract cancer regimen, i.e. cisplatin and gemcitabine. Unfortunately, the clinical response was short-lived; the disease progressed, the patient was offered best supportive care and died two months after the diagnosis. The case underpins the literature review with respect to differential diagnosis of an elevated hCG concentration. In particular, we discuss ectopic secretion in non-trophoblastic and non-germinal malignancies and the causes of false positive assays.We present a case of a 34-year-old male patient referred to our Uro-oncology Department with a suspicion of a metastatic germ cell tumour, owing to enlarged left testicle and elevated β-hCG concentration (39 mIU/ml). Impaired performance status caused by extensive pulmonary and liver metastases, accompanied by significant lymphadenopathy, necessitated prompt management. However, a testicular tumour was excluded by ultrasound examination; a hydrocele only was found. The β-hCG concentration was not increasing (37 mIU/ml). We found a diagnosis of an extragonadal germ cell tumour doubtful, and a liver biopsy was performed. Due to the patientâs quick deterioration, we decided to commence pre-phase chemotherapy with cisplatin and etoposide, which resulted in a significant clinical improvement. The pathological examination, along with immunoassays, revealed undifferentiated cholangiocarcinoma, and the patient continued chemotherapy with a biliary tract cancer regimen, i.e. cisplatin and gemcitabine. Unfortunately, the clinical response was short-lived; the disease progressed, the patient was offered best supportive care and died two months after the diagnosis. The case underpins the literature review with respect to differential diagnosis of an elevated hCG concentration. In particular, we discuss ectopic secretion in non-trophoblastic and non-germinal malignancies and the causes of false positive assays
Video-based Simulations: Considerations for Teaching Students with Developmental Disabilities
The use of video-based multimedia simulations for teaching functional skills to persons with developmental disabilities remains an unexplored application of technology for this group. This article examines the historical literature in this area, and discusses future considerations, design issues, and implications of using multimedia simulations. Implementation issues are presented, and suggestions regarding design, development, and application of multimedia simulations are offered. Considerations address the importance of appropriate role modeling and the combination of video-based simulation and in vivo training to foster generalization and maintenance in the context of transition to the real world.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
Iminosugar-Based Inhibitors of Glucosylceramide Synthase Increase Brain Glycosphingolipids and Survival in a Mouse Model of Sandhoff Disease
The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS) to decrease the synthesis of glucosylceramide and related glycosphingolipids that accumulate in the lysosomes. Genz-529468, a blood-brain barrier-permeant iminosugar-based GCS inhibitor, was used to evaluate this concept in a mouse model of Sandhoff disease, which accumulates the glycosphingolipid GM2 in the visceral organs and CNS. As expected, oral administration of the drug inhibited hepatic GM2 accumulation. Paradoxically, in the brain, treatment resulted in a slight increase in GM2 levels and a 20-fold increase in glucosylceramide levels. The increase in brain glucosylceramide levels might be due to concurrent inhibition of the non-lysosomal glucosylceramidase, Gba2. Similar results were observed with NB-DNJ, another iminosugar-based GCS inhibitor. Despite these unanticipated increases in glycosphingolipids in the CNS, treatment nevertheless delayed the loss of motor function and coordination and extended the lifespan of the Sandhoff mice. These results suggest that the CNS benefits observed in the Sandhoff mice might not necessarily be due to substrate reduction therapy but rather to off-target effects
Parental Perspectives on Curriculum Priorities for their Young Children with Disabilities
Beech understoreys in pine forests as places that partly favour the functioning of forest assemblages of ground beetles (Col. Carabidae) in coniferous forest habitats
This study investigates the effect of the enrichment of Scots pine stands with a common beech understorey on changes in the species composition and selected life traits of an important zooindicator group, such as the ground beetles (Col. Carabidae). The field investigations were carried out in a fresh coniferous forest in the Myszyniec Forest District (N Poland) in stands with (P+) and without (P) beech in the understorey. Each treatment was repeated four times. In each repetition, six pitfalls were installed. The traps were replaced 13 times, every two weeks, from April to October. In total, 4412 specimens classified into 25 species of ground beetles were captured. The tree stands with the beech understorey were observed to contain a significantly higher number of species than the ones with the beech undergrowth. Also, the value of the Shannon index of species diversity (Hâ) and mean individual biomass (MIB) were significantly higher in the treatment with the beech understorey. Principal Component Analysis showed variations in Carabidae assemblages within the analysed types of forest. Pterostichus oblongopunctatus, Pterostichus aethiops and Pterostichus vernalis were more strongly correlated with the stands without beech
understorey. The stands enriched with the beech understorey correlated with the occurrence of large zoophages: Carabus arvensis and Cychrus caraboides, and hemizoophages of the genus Amara. An inâdepth ecological characterisation of the captured Carabidae showed that the dominant ground beetles in the investigated forest habitats, in terms of the number of caught individuals and species, belonged to forest zoophagous carabids characterised by moderate requirements for moisture in a habitat, and having the spring type of development. Representatives of large zoophages and species with the autumn type of development, i.e. species associated with later ecological succession stages, were more numerously caught in the pine stands without the beech understorey The study provides evidence that justifies the planting of deciduous undergowth in monoculture coniferous pine tree forests. The presence of an understorey contributes to higher: richness of Carabidae species, values of the MIB and abundance of large forest species presenting the autumn type of development, that is the species, which are characteristic for forest areas representing a highly advanced succession stage
Soil management system in hazelnut groves (Corylus sp.) versus the presence of ground beetles (Coleoptera: Carabidae)
Sustaining biodiversity as well as taking advantage of the natural environmentâs resistance are the key elements which
should be considered when designing integrated plans for the protection of hazelnut groves. An effort has been made in this study
to analyse the impact of different soil cultivation methods in hazelnut groves, on the species composition and number of individuals
in carabid assemblages (Coleoptera: Carabidae). Another aim was to determine which method of inter-row soil management had the
least negative effect on assemblages of these beetles. Because of the type of habitat, the xerothermic species characteristic for southeastern
Europe, i.e. Calathus ambiguus, Poecilus lepidus, Harpalus calceatus, and H. griseus, were the most numerous. The qualitative and
quantitative analysis of the captured individuals implied that the optimal soil tillage system in young hazelnut groves is when soil
is kept fallow with machines or chemicals, or when soil is covered with manure. The least favourable practice for the appearance of
ground beetles of the Carabidae family is the use of polypropylene fabric, bark or sawdust, to cover soil
Assemblages of Carabidae in a forest peat bog reserve situated in an urban agglomeration
The paper discusses the species composition and structure of ground beetles (Col., Carabidae) assemblages inhabiting different areas in "Mszar" peat bog reserve. The discussion is followed by an evaluation of the natural condition of this habitat. The observations were carried out in 2006â2007 and comprised three different areas of "Mszar" peat bog reserve: birch forest on lowland peat bog, mixed forest on peat soils and spruce stand inside wet mixed forest. Carabid beetles were captured in modified pitfall (Barber) traps. An ecological analysis of carabids was worked out on the basis of their geographical distribution, foraging, habitat and moisture demands and type of development. It was found out that the assemblages of ground
beetles living in the peat bog reserve, in terms of species diversity, were similar to those in other peat bogs in northâeastern Poland and northâwestern Belarus. The species composition, structure of dominance classes and lack of stenobiotic peat bog species, however, may indicate that the state of equilibrium in "Mszar" peat bog reserve has been distrubed. The reasons could involve increasing manâmade pressure (roads, tourist trails and a wastewater treatment plant in close vicinity)
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