Dilepton Signal of a Type-II Seesaw at CERN LHC: Reveals a TeV Scale B-L Symmetry

We explore the discovery potential of doubly charged Higgs bosons (\xi^{\pm\pm}) at the CERN Large Hadron Collider (LHC). For moderate values of the coupling constants in the original Type-II seesaw model, these doubly-charged Higgs bosons are not accessible by any present or near future collider experiments. In a gauged B-L symmetric model we introduce two triplet scalars to execute a variant of type-II seesaw at the TeV scale. This leads to a clear like-sign dilepton signal in the decay mode of \xi^{\pm\pm} for a small vacuum expectation value (\lsim 10^5 \eV) of the triplet scalar \xi= (\xi^{++}, \xi^+, \xi^0) of mass \lsim 1 \TeV. To be specific, for a mass range of 200-1000 GeV of \xi^{\pm\pm}, the like-sign dilepton signal can be detected at CERN LHC at a center of mass energy 14 TeV with an integrated luminosity > 30 {\rm fb}^{-1}. The same analysis is also pursued with center of mass energies 7 TeV and 10 TeV as well. We also comment on the decay mode of singly charged scalars and neutral B-L gauge boson in this model.Comment: Minor change in Introduction, Z' contribution to the production of doubly charged scalars are explicitly shown, new figures added, new references added. To appear in Physical Review

ACCELERATED STABILITY STUDY OF CHITRAK HARITAKI AVALEHA

Objective: Accelerated stability study of Chitrak Haritaki avaleha was done for six months to know the stability of formulation in reference of its phyto-constituents and microbial growth therein.Methods: Chitrak Haritaki avaleha was made in laboratory following classical method [Sample lab (SL)] as per AFI part-1(The Ayurvedic formulary of India, part-1) and two samples were collected from local market [Market Sample-1(MK-1) & Market sample-2 (MK-2)] of reputed brand. These three samples were put in controlled condition following ICH (International Conference on Harmonization) guidelines for accelerated stability study for six months. The intermediate samplings were done at starting, after one, three and six month respectively. These samples were investigated for reducing sugar, phyto-constituents (Total tannins, piperine, vitamin C and total polyphenols contents), microbial load and their organoleptic characteristics. Results: All the results were calculated and compared for variation during course of time. Variation in the result of samples was evaluated against Arrhenius equation which ensured that formulation was stable over two years and no significant variation was found over six month of accelerated stability condition.Conclusion: Since it is traditional avalehakalpana, the shelf life period was about one year (Sharangdhar Samhita) and updated to three year in Drug and cosmetic rule 1945, 161B. The presented study reflect that Chitrak Haritaki avaleha was stable over two year (by taking inference from Arrhenious equation) and more sophisticated packing may improve the shelf life period.Keywords: Avaleha, Shelf life, Accelerated stability, Chitrak Haritaki avaleha

Shape-memory properties of magnetically active triple-shape nanocomposites based on a grafted polymer network with two crystallizable switching segments

Thermo-sensitive shape-memory polymers (SMP), which are capable of memorizing two or more different shapes, have generated significant research and technological interest. A triple-shape effect (TSE) of SMP can be activated e.g. by increasing the environmental temperature (Tenv), whereby two switching temperatures (Tsw) have to be exceeded to enable the subsequent shape changes from shape (A) to shape (B) and finally the original shape (C). In this work, we explored the thermally and magnetically initiated shape-memory properties of triple-shape nanocomposites with various compositions and particle contents using different shape-memory creation procedures (SMCP). The nanocomposites were prepared by the incorporation of magnetite nanoparticles into a multiphase polymer network matrix with grafted polymer network architecture containing crystallizable poly(ethylene glycol) (PEG) side chains and poly(ε-caprolactone) (PCL) crosslinks named CLEGC. Excellent triple-shape properties were achieved for nanocomposites with high PEG weight fraction when two-step programming procedures were applied. In contrast, single-step programming resulted in dual-shape properties for all investigated materials as here the temporary shape (A) was predominantly fixed by PCL crystallites

A Study on Sanctuary and Seclusion Issues in Internet-of-Things

Internet-of-Things (IoT) are everywhere in our daily life. They are used in our homes, in hospitals, deployed outside to control and report the changes in environment, prevent fires, and many more beneficial functionality. However, all those benefits can come of huge risks of seclusion loss and sanctuary issues. To secure the IoT devices, many research works have been con-ducted to countermeasure those problems and find a better way to eliminate those risks, or at least minimize their effects on the user�s seclusion and sanctuary requirements. The study consists of four segments. The first segment will explore the most relevant limitations of IoT devices and their solutions. The second one will present the classification of IoT attacks. The next segment will focus on the mechanisms and architectures for authentication and access control. The last segment will analyze the sanctuary issues in different layers

Land characterization and soil-site suitability- evaluation of banana growing areas of South Gujarat, India

An investigation was carried out to evaluate the soil-site suitability and land characterization in some banana growing soils of South Gujarat. The soil belongs to Vertisols, Inceptisols and Enitisols soil order. Banana growing soil (Pedon-1) of Narmada district have ochric epipedon whereas, pedon 2, 3, 4,5, 6 and 9 are placed in order Inceptisols owing to ochric epipedon followed by cambic horizon (changes in colour, structure and texture). The presence of smectite mineralogy class, hyperthermic soil moisture regime and more than 30 per cent clay (but less than 60 per cent), pedon 7 and 8 classified as Inceptisols. In respect of land characteristics, The cumulative rating index of Jhagadia (PN2), Bardoli (PN5) and Palsana (P6) coming under highly sustainable (S2). Whereas, rest of the pedon i.e., Narmada (P1), Bharuch (PN3), Kamrej (PN4) Navsari (PN7), Jalalpore (PN8) and Valsad (PN9) are sustainable under high input (S3). Considering the soil-site suitability criteria, Bharuch (PN3), Palsana (PN6) and Jalalpore (PN8) are identified as highly suitable talukas for banana cultivation. While the Narmada (PN1), Jhagadia (PN2), Kamrej (PN4), Bardoli (PN5), Navsari (PN7) and Valsad (PN9) were categorized in moderately suitable class (S2). The suitability class can be improved if the correctable limitations (soil fertility characteristics) are altered through soil amelioration measures

Land characterization and soil-site suitability- evaluation of banana growing areas of South Gujarat, India

An investigation was carried out to evaluate the soil-site suitability and land characterization in some banana growing soils of South Gujarat. The soil belongs to Vertisols, Inceptisols and Enitisols soil order. Banana growing soil (Pedon-1) of Narmada district have ochric epipedon whereas, pedon 2, 3, 4,5, 6 and 9 are placed in order Inceptisols owing to ochric epipedon followed by cambic horizon (changes in colour, structure and texture). The presence of smectite mineralogy class, hyperthermic soil moisture regime and more than 30 per cent clay (but less than 60 per cent), pedon 7 and 8 classified as Inceptisols. In respect of land characteristics, The cumulative rating index of Jhagadia (PN2), Bardoli (PN5) and Palsana (P6) coming under highly sustainable (S2). Whereas, rest of the pedon i.e., Narmada (P1), Bharuch (PN3), Kamrej (PN4) Navsari (PN7), Jalalpore (PN8) and Valsad (PN9) are sustainable under high input (S3). Considering the soil-site suitability criteria, Bharuch (PN3), Palsana (PN6) and Jalalpore (PN8) are identified as highly suitable talukas for banana cultivation. While the Narmada (PN1), Jhagadia (PN2), Kamrej (PN4), Bardoli (PN5), Navsari (PN7) and Valsad (PN9) were categorized in moderately suitable class (S2). The suitability class can be improved if the correctable limitations (soil fertility characteristics) are altered through soil amelioration measures

A SHORT REVIEW ON POLYCYSTIC OVARY SYNDROME

Polycystic ovary syndrome (PCOS) is said to be the commonest endocrine disorder in women of reproductive age with a heterogeneous presentation, which includes hyperandrogenism and ovulatory dysfunction. Polycystic ovary syndrome usually has a peri-pubertal onset;the present review discuss about the causes,complications,risck factors,dianosis and treatment.Key words:Polycystic ovary syndrome (PCOS),Hyperandrogenism,Treatmen

LIQUID CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS QUANTITATIVE DETERMINATION OF CANDESARTAN CILEXETIL AND HYDROCHLORTHIAZIDE IN PHARMACEUTICAL DOSAGE FORMS

A simple and sensitive RP-HPLC method was developed and validated for the determination of Candesartan cilexetil and Hydrochlorthiazide in pharmaceutical dosage forms. The separation of components was achieved on a SHIMADZU Hypersil ODS-C18 column (250 × 4.6 mm, 5 µm) with UV detection at 270 nm. Isocratic elution with a mobile phase consisting of 10 mM (pH 3.37) Tetra butyl ammonium hydrogen sulphate: methanol (15:85, V/V), at a flow rate 1.0 mL min-1 was employed. Linearity was observed in the concentration range 0.625-62.5 µg/mL for Hydrochlorthiazide and 0.8-80 µg/mL for Candesartan cilexetil respectively. The linear regression equation was found to be Y=64002X-1412.6 for Hydrochlorthiazide and Y=24649X-6701.8 for Candesartan cilexetil respectively with correlation coefficients greater than 0.999. The LOD was found to be 0.1385 and 0.1892 µg/mL for Hydrochlorthiazide and Candesartan cilexetil respectively where as the LOQ was found to be 0.4394 and 0.6187 µg/mL for Hydrochlorthiazide and Candesartan cilexetil respectively. The mean analytical recovery in determination of Candesartan cilexetil and Hydrochlorthiazide tablets was 99.31-100.08% Hydrochlorthiazide and 99.58-100.39% for Candesartan cilexetil respectively. Thus, the proposed method is applicable for routine determination of Candesartan cilexetil and Hydrochlorthiazide in pharmaceutical formulations

DEVELOPMENT AND VALIDATION OF THE STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD FOR RIFAXIMIN -AN ANTIBIOTIC

An isocratic reversed-phase high-performance liquid chromatographic method was developed and validated for the determination of rifaximin. The samples were analyzed by high-performance liquid chromatography (HPLC). Chromatographic separation was achieved on a C18 column using an aqueous tetra butyl ammonium hydrogen sulphate: methanol (10:90, v/v), with flow rate 1.0 mL/min (UV detection at 454 nm). Linearity was observed over the concentration range of 1.0–200 μg/mL with regression equation 15407x +6677 (R2 = 0.9999). The LOQ was found to be 0.786μg/mL and the LOD was found to be 0.238μg/mL. Rifaximin was subjected to stress conditions of degradation in aqueous solutions including acidic, alkaline, oxidation, photolysis and thermal degradation. The forced degradation studies were performed by using HCl, NaOH, H2O2, thermal and UV radiation. Rifaximin is more sensitive towards acidic conditions in comparison to oxidation and very much resistant towards alkaline, thermal and photolytic degradations. The method was validated as per ICH guidelines. The RSD for intra-day (0.28-0.55) and inter-day (0.68-0.81) precision were found to be less than 1 %. The percentage recovery was in good agreement with the labelled amount in the pharmaceutical formulations and the method is simple, specific, precise, robust and accurate for the determination of Rifaximin in pharmaceutical formulations