460 research outputs found
The functional status of forestry industry workers in the Far North during the shift period
All over the world, the timber industry is one of the most physically hazardous industries. Working in such conditions is accompanied by an increase in the risk of unfavorable functional states and a critical decrease in professional reliability. Monitoring the workersβ state during the shift period will allow to determine the adaptation degree of personnel to work, as well as to identify the days of the shift arrival with a high risk of injury caused by the unfavorable state of workers.The aim. To identify and describe the functional states dynamics of loggers during the entire shift period in the Far North as their adaptation degree to work.Methods. Objective: collection of saliva for the determination of cortisol, psychophysiological instrumental methods; projective: M. Luscherβs color test; subjective β questionnaire βWell-being. Activity. Moodβ by V.Π. Doskin et al.; statistical methods: descriptive statistics. The study involved 24 shift workers of a logging enterprise, with whom we conducted daily monitoring of objective, projective and subjective characteristics of their functional state in the morning and evening during a fourteenday shift visit.Results. According to the objective, projective and subjective indicators of functional states, their consistently favorable level is observed with multidirectional peaks during the shift change period and a slight decrease at the end of the shift, which demonstrates the staffβ adaptability to work. The operator performance is somewhat higher in the second half of the shift period, but in general it is below average due to the reduced quality of task performance. An increased free cortisol level was revealed in employees during the entire shift period with a high functional reserves level of the body. During the shift change period, the risks associated with the efficiency and safety of labor increase, which undoubtedly requires consideration by the management of enterprises
Interrelation of individual-personal qualities and dynamics of functional states participants of the sea Arctic expedition
The issues of psychological adaptation of a person to the extreme conditions of the Arctic continue to be relevant at the present time. Dynamic monitoring of human functional states is an effective technology that allows timely identification of the level of human adaptation to the conditions of the North and implementation of preventive measures to maintain health in extreme working conditions.Β Β The aim of the studyΒ is to identify and describe the relationship of individual-personal qualities and the dynamics of the functional states of the participants of the marine Arctic expedition.Β Β Methods.Β Psychophysiological testing using the device UPFT-1/30-Β«PsychophysiologΒ» (variational cardiointervalometry, complex visual-motor reaction); color preference test (M. Luscher, adapted by L. N. Sobchik) with calculation of interpretation coefficients by G. A. Aminev; Five-factor personality questionnaire (R. McCrae and P. Costa, adapted by A. B. Khromov); statistical methods: descriptive statistics, frequency analysis, correlation analysis using Spearmanβs rank correlation coefficient. The study was conducted daily in the morning and evening for 20 days on the research vessel Mikhail Somov in June 2021. The study involved 39 people, including participants in the scientific and educational expeditionary project βArctic Floating Universityβ2021β.Β Β Results.Β The dynamics of psychophysiological and projective psychological parameters of the functional states of the expedition members as a whole is characterized by favorable levels, which indicates their adaptation to the conditions of high latitudes. According to the results of the correlation analysis, statistically significant relationships were revealed between the dynamics of functional states and such individual-personal qualities as: extraversion β introversion and attachment β separation.Β Β Conclusion.Β The results of the study are consistent with the data of previous expeditions of the βArctic floating universityβ and other polar expeditions. The revealed interrelations of functional states with different personality characteristics of the participants testify in favor of the complex nature of the study using different groups of diagnostic methods
Informative significance of serum cytokines and their importance for development of metabolic syndrome with arterial hypertension in elderly persons
Metabolic syndrome (MS) is among the main public health challenges worldwide, leading to significant labor losses, increased costs for treatment and rehabilitation of the patients. The aim of the present study was to identify the informative serum interleukins, by determining the odds ratio in elderly patients with MS and hypertension. The main group of 86 patients with MS and arterial hypertension (AH) aged 60-75 years was examined under clinical conditions. The inclusion criteria were as follows: age of 60-75 years, presence of MS, primary hypertension (grade II-III), absence of acute myocardial infarction, malignant neoplasms, disorders of cerebral circulation, kidney failure over last 6 months. Diagnostics of MS and hypertension was carried out in accordance with Expert Guidelines from the Russian Research Society of Cardiology on the MS Diagnosis and Treatment. Our first study of a large range of serum interleukins in elderly patients with MS and hypertension allowed us to reveal the inversely directed changes in pro- and anti-inflammatory cytokine contents. Combined AH/MS in elderly persons is accomplished by sufficient increase of the most proinflammatory cytokines, and vice versa, by significant decrease in anti-inflammatory cytokines in blood serum. This finding clearly points to importance of immunological regulatory systems for initiation of AH with MS at older age. Pro- and anti-inflammatory serum interleukins are actively involved into the AH/MS development in elderly accompanied by their pronounced imbalance. The mentioned immune reactions could underlie the MS/AH condition. High risk of this disorder is connected with changed production of proinflammatory cytokines (IL-8, IL-1Ξ²), like as anti-inflammatory serum interleukins (IL-4, IL-10), with predominance of the former. The above interleukins should be considered dominant diagnostic markers of AH/MS in elderly persons. Measurement of serum interleukins and discriminant-based approach allows highly reliable differentiation of elderly patients with AH/MS from similar individuals without this disorder
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΡΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° Π² ΡΠΊΠ°Π½ΠΈ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π΄ΠΎ ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΊΡΡΡΠΎΠ² Ρ ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ
The aim of the study is to analyze the changes in the elastic fibers and the expression features of elastinbinding protein-1, lysyl oxidase-1, and tetraspanin CD151 in the invasive ductal breast cancer tissues before and after chemotherapy courses. The study included 34 patients with invasive ductal breast cancer. The patients were divided into two groups: the first group had surgical resection of the tumor before chemotherapy, and the second group had surgical resection of the residual tumor after neoadjuvant chemotherapy. The frequency of elastic fibers accumulations around the ducts in patients without chemotherapy was significantly higher (61.1 %) than that in patients after neoadjuvant chemotherapy (25.0 %). After chemotherapy, the expression of elastin-binding protein-1 changed: the proportion of patients with a strong expression of this protein in tumor cells after chemotherapy increased (62.5 %) in comparison to patients without chemotherapy (16.8 %). The combined cytoplasmic and/or membrane expression of elastin-binding protein-1 in the tumor cells predominated in the second group compared with diffuse cytoplasmic expression (55.0 %) in tumor cells of patients of the first group.Β Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠΈΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠ°ΡΠΊΠ°ΡΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ»Π°ΡΡΠΈΠ½-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ°-1, Π»ΠΈΠ·ΠΈΠ»ΠΎΠΊΡΠΈΠ΄Π°Π·Ρ-1 ΠΈ ΡΠ΅ΡΡΠ°ΡΠΏΠ°Π½ΠΈΠ½Π° CD151 Π² ΡΠΊΠ°Π½ΠΈ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π΄ΠΎ ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Π½Π° Π°ΡΡ
ΠΈΠ²Π½ΠΎΠΌ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΠΎΡ 34 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΡΠΌ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Β«ΠΈΠ½ΡΠΈΠ»ΡΡΡΠΈΡΡΡΡΠ°Ρ ΠΏΡΠΎΡΠΎΠΊΠΎΠ²Π°Ρ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·ΡΒ». ΠΡΠ»ΠΎ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΎ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ: ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΠΏΠΎΠ»Π½ΡΠ»Π°ΡΡ ΡΠ΅Π·Π΅ΠΊΡΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π΄ΠΎ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ, Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π½Π΅ΠΎΠ°Π΄ΡΡΠ²Π°Π½ΡΠ½ΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π±Π΅Π· Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°ΡΡΠΎΡΠ° Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ
ΡΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠΉ ΡΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ Π²ΠΎΠΊΡΡΠ³ ΠΏΡΠΎΡΠΎΠΊΠΎΠ² Π±ΡΠ»Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²ΡΡΠ΅ (61,1 %), ΡΠ΅ΠΌ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π½Π΅ΠΎΠ°Π΄ΡΡΠ²Π°Π½ΡΠ½ΡΡ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ (25 %). ΠΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅ΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ»Π°ΡΡΠΈΠ½-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ°-1: Π½Π° Π΄ΠΎΠ»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° ΠΏΡΠΈΡ
ΠΎΠ΄ΠΈΡΡΡ 62,5 % Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΉ, ΠΏΡΠΎΡΠΈΠ² 16,8 % ΡΠ»ΡΡΠ°Π΅Π² Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π±Π΅Π· Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ Ρ ΠΏΠ΅ΡΠ²ΡΡ
ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ ΡΠΎΡΠ΅ΡΠ°Π½Π½Π°Ρ ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈ/ΠΈΠ»ΠΈ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½Π°Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ, Π° Ρ Π²ΡΠΎΡΡΡ
ΠΎΠΊΠΎΠ»ΠΎ 55 % ΠΏΡΠΈΡ
ΠΎΠ΄ΠΈΡΡΡ Π½Π° Π΄ΠΈΡΡΡΠ·Π½ΡΡ ΡΠ°Π²Π½ΠΎΠΌΠ΅ΡΠ½ΡΡ ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ.
Composition and crystallization conditions of olivine-phyric rocks from Kamchatsky Mys peninsula
Polymorphism C677T MTHFR gene and metabolic syndrome in young residents of the northern region
The aim of the work was to study the association of polymorphism C677T (rs1801133) of the MTHFR gene with components of the metabolic syndrome in young indigenous and non-indigenous people of the northern region. 834 young people aged 18-44 years were examined, of them 695 parents with manifestations of metabolic syndrome and 139 healthy young people. It was revealed that 28.7% of all surveyed were carriers of the T is1801133 (C677T) allele of the MTHFR gene as-sodated with the risk of developing cardiovascular diseases. No significant differences were found among non-indigenous and indigenous people in the carrierfrequency of theT allele. Associations of rs1801133C677T polymorphisms of the MTHFR gene with components of MS were studied. Among the non-indigenous male population with carriers of the homozygous TT genotype, a tendency has been established to reduce the chances of developing hypertriglyceridemia and an increase in LDL cholesterol levels. In men of the indigenous ethnic group of carriers of the TT genotype, there is a tendency to increase the chances of reducing the level of HDL cholesterol and increasing the chances of developing hyperglycemia. Among non-indigenous female carriers of the homozygous TT genotype, a tendency was established to reduce the likelihood of developing abdominal obesity. Among indigenous women, the carriage of a homozygous TT is associated with arterial hypertension.Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π‘677Π’ (($1801133) Π³Π΅Π½Π° MTHFR Ρ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Ρ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΈ Π½Π΅ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΆΠΈΡΠ΅Π»Π΅ΠΉ ΡΠ΅Π²Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π³ΠΈΠΎΠ½Π°. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 834 ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 18-44 Π³ΠΎΠ΄Π°, ΠΈΠ· Π½ΠΈΡ
695 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΈ 139 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
Π»ΡΠ΄Π΅ΠΉ. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ 28,7% Π²ΡΠ΅Ρ
ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ²Π»ΡΠ»ΠΈΡΡ Π½ΠΎΡΠΈΡΠ΅Π»ΡΠΌΠΈ Π°Π»Π»Π΅Π»Ρ Π’ rs1801133 (Π‘677Π) Π³Π΅Π½Π° MTHFR, ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠ³ΠΎ Ρ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΒΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π‘ΡΠ΅Π΄ΠΈ Π½Π΅ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΈ ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΆΠΈΡΠ΅Π»Π΅ΠΉ ΠΏΠΎ ΡΠ°ΡΡΠΎΡΠ΅ Π½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²Π° Π°Π»Π»Π΅Π»Ρ Π’ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΡ
ΡΠ°Π·Π»ΠΈΡΠΈΠΉ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ. ΠΠ·ΡΡΠ΅Π½Ρ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² rs1801133 Π‘677Π’ Π³Π΅Π½Π° MTHFR Ρ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ ΠΠ‘. Π‘ΡΠ΅Π΄ΠΈ Π½Π΅ΠΊΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΌΡΠΆΡΠΊΠΎΠ³ΠΎ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ-Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° Π’Π’ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ°Π½ΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ Π³ΠΈΠΏΠ΅ΡΡΡΠΈΡΠΈΡΠ΅ΡΠΈΠ΄Π΅ΠΌΠΈΠΈ, ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ Π₯Π‘ ΠΠΠΠ. Π£ ΠΌΡΠΆΡΠΈΠ½ ΠΊΠΎΡΠ΅Π½Π½ΠΎΠΉ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° Π’Π’ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΠ°Π½ΡΠΎΠ² ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ Π₯Π‘ ΠΠΠΠ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΠ°Π½ΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ Π³ΠΈΠΏΠ΅ΡΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΠΈ. Π‘ΡΠ΅Π΄ΠΈ Π½Π΅ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½ Π½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΈΡ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° Π’Π’ Π±ΡΠ»Π° ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΡ. Π£ ΠΊΠΎΡΠ΅Π½Π½ΡΡ
ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»ΡΠ½ΠΈΡ Π½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²ΠΎ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π’Π’ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½ΠΎ Ρ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ΅ΠΉ
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