Polymer Amide as an Early Topology

Hydrophobic polymer amide (HPA) could have been one of the first normal density materials to accrete in space. We present ab initio calculations of the energetics of amino acid polymerization via gas phase collisions. The initial hydrogen-bonded di-peptide is sufficiently stable to proceed in many cases via a transition state into a di-peptide with an associated bound water molecule of condensation. The energetics of polymerization are only favorable when the water remains bound. Further polymerization leads to a hydrophobic surface that is phase-separated from, but hydrogen bonded to, a small bulk water complex. The kinetics of the collision and subsequent polymerization are discussed for the low-density conditions of a molecular cloud. This polymer in the gas phase has the properties to make a topology, viz. hydrophobicity allowing phase separation from bulk water, capability to withstand large temperature ranges, versatility of form and charge separation. Its flexible tetrahedral carbon atoms that alternate with more rigid amide groups allow it to deform and reform in hazardous conditions and its density of hydrogen bonds provides adhesion that would support accretion to it of silicon and metal elements to form a stellar dust material

Polymer amide as a source of the cosmic 6.2 micron emission and absorption

Cosmic infrared emission and absorption spectra often carry a well-defined and invariant 6.2 micron band that has been proposed to emanate from very small dust grains that may carry polyaromatic hydrocarbons. Hemoglycin, a well-defined polymer of glycine that also contains iron, has been found in meteorites of the primordial CV3 class and therefore originated in the solar protoplanetary disc. In approximate calculations, the principal amide I infrared absorption band of hemoglycin is at 6.04 microns. Hemoglycin, an antiparallel beta sheet structure with two 11-mer glycine chains, has an exact structural analog in antiparallel poly-L-lysine beta sheets which in the laboratory have an absorption peak at 6.21 microns. This wavelength coincidence, the demonstrated propensity of hemoglycin 4.9nm rods to form accreting lattice structures, and its proven existence in the solar protoplanetary disc strongly suggest that the cosmic 6.2 micron emission and absorption could be from small grains that are hemoglycin lattices or shell-like vesicles carrying internal organic molecules of various types. Calculated hemoglycin ultraviolet absorptions associated with iron in the molecule match the observed ultraviolet extinction feature at nominal 2175 Angstroms.Comment: 8 pages, 4 figure

The K-Server Dual and Loose Competitiveness for Paging

This paper has two results. The first is based on the surprising observation that the well-known ``least-recently-used'' paging algorithm and the ``balance'' algorithm for weighted caching are linear-programming primal-dual algorithms. This observation leads to a strategy (called ``Greedy-Dual'') that generalizes them both and has an optimal performance guarantee for weighted caching. For the second result, the paper presents empirical studies of paging algorithms, documenting that in practice, on ``typical'' cache sizes and sequences, the performance of paging strategies are much better than their worst-case analyses in the standard model suggest. The paper then presents theoretical results that support and explain this. For example: on any input sequence, with almost all cache sizes, either the performance guarantee of least-recently-used is O(log k) or the fault rate (in an absolute sense) is insignificant. Both of these results are strengthened and generalized in``On-line File Caching'' (1998).Comment: conference version: "On-Line Caching as Cache Size Varies", SODA (1991

A spatial assessment of Brassica napus gene flow potential to wild and weedy relatives in the fynbos biome

The original publication is available at http://www.scielo.org.za/Gene flow between related plant species, and between transgenic and non-transgenic crop varieties, may be considered a form of biological invasion. Brassica napus (oilseed rape or canola) and its relatives are well known for intra- and inter-specific gene flow, hybridisation and weediness. Gene flow associated with B. napus poses a potential ecological risk in the Fynbos Biome of South Africa, because of the existence of both naturalised (alien, weedy) and native relatives in this region. This risk is particularly pertinent given the proposed use of B. napus for biofuel and the potential future introduction of herbicide-tolerant transgenic B. napus. Here we quantify the presence and co-occurrence of S. napus and its wild and weedy relatives in the Fynbos Biome, as a first step in the ecological risk assessment for this crop. Several alien and at least one native relative of B. napus were found to be prevalent in the region, and to be spatially congruent with B. napus fields. The first requirement for potential gene flow to occur has thus been met. In addition, a number of these species have elsewhere been found to be reproductively compatible with S. napus. Further assessment of the potential ecological risks associated with B. napus in South Africa is constrained by uncertainties in the phylogeny of the Brassicaceae, difficulties with morphology-based identification, and poor knowledge of the biology of several of the species involved, particularly under South African conditions.Publishers' versio

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

This work was funded by the Chief Scientists Office of the Scottish Government by a joint grant to the University of the Highland and Islands, Grampian Health Board, Biomathematics and Statistics Scotland and the Rowett Institute of Nutrition and Health, University of Aberdeen. Additional support was provided by Provexis plc.Peer reviewedPublisher PD