Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment

Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal antibodies are making major contributions to this progress. As a consequence, the options for treatment of CLL are considerably more diverse now than a few years ago, and now include procedures that take into account age and risk. At the same time, it should be emphasized that many important questions regarding the treatment of CLL remain unresolved. It is anticipated that these questions will be answered over the coming few years by including patients in multicentre studies like those being carried out by the German CLL study group

Black hole singularities: a new critical phenomenon

The singularitiy inside a spherical charged black hole, coupled to a spherical, massless scalar field is studied numerically. The profile of the characteristic scalar field was taken to be a power of advanced time with an exponent $\alpha>0$. A critical exponent $\alpha_{\rm crit}$ exists. For exponents below the critical one ($\alpha<\alpha_{\rm crit}$) the singularity is a union of spacelike and null sectors, as is also the case for data with compact support. For exponents greater than the critical one ($\alpha>\alpha_{\rm crit}$) an all-encompassing, spacelike singularity evolves, which completely blocks the ``tunnel'' inside the black hole, preventing the use of the black hole as a portal for hyperspace travel.Comment: 4 pages, 5 eps figures; An Erratum is added. The main conclusions of the original Letter are unchange

Chromogranin A in neurons of the rat cerebellum and spinal cord: quantification and sites of expression

Chromogranin A (CGA) is an abundant protein of dense-cored secretory vesicles in endocrine and neuronal cells. The present study, for the first time, compares CGA of neurons of the central nervous system with the CGA of adrenal origin. By S1 nucleus protection assay, we found that the 3' part of the CGA mRNA between exons 5-8 of the cerebellum and the spinal cord of the rat is homologous to that of the adrenal. In situ hybridization histochemistry revealed that CGA mRNA in the cerebellar cortex is present in cell bodies of Purkinje cells and in neurons of the deep cerebellar nuclei. The perikarya of these cells also exhibit CGA-like immunoreactivity. CGA mRNA and CGA-like immunoreactivity are also present in the motoneurons of the ventral, lateral, and dorsal horns of the rat spinal cord. The amounts of CGA, as determined by radioimmunoassay in cerebellum and spinal cord, were about one tenth of the amounts detected in the adrenal, adenohypophysis, or the olfactory bulb. The sites of CGA expression suggest that CGA may be involved in signal transduction in the motor system

Longitudinal Atomic Beam Spin Echo Experiments: A possible way to study Parity Violation in Hydrogen

We discuss the propagation of hydrogen atoms in static electric and magnetic fields in a longitudinal atomic beam spin echo (lABSE) apparatus. Depending on the choice of the external fields the atoms may acquire both dynamical and geometrical quantum mechanical phases. As an example of the former, we show first in-beam spin rotation measurements on atomic hydrogen, which are in excellent agreement with theory. Additional calculations of the behaviour of the metastable 2S states of hydrogen reveal that the geometrical phases may exhibit the signature of parity-(P-)violation. This invites for possible future lABSE experiments, focusing on P-violating geometrical phases in the lightest of all atoms.Comment: 6 pages, 4 figure

TinkerCell: Modular CAD Tool for Synthetic Biology

Synthetic biology brings together concepts and techniques from engineering and biology. In this field, computer-aided design (CAD) is necessary in order to bridge the gap between computational modeling and biological data. An application named TinkerCell has been created in order to serve as a CAD tool for synthetic biology. TinkerCell is a visual modeling tool that supports a hierarchy of biological parts. Each part in this hierarchy consists of a set of attributes that define the part, such as sequence or rate constants. Models that are constructed using these parts can be analyzed using various C and Python programs that are hosted by TinkerCell via an extensive C and Python API. TinkerCell supports the notion of a module, which are networks with interfaces. Such modules can be connected to each other, forming larger modular networks. Because TinkerCell associates parameters and equations in a model with their respective part, parts can be loaded from databases along with their parameters and rate equations. The modular network design can be used to exchange modules as well as test the concept of modularity in biological systems. The flexible modeling framework along with the C and Python API allows TinkerCell to serve as a host to numerous third-party algorithms. TinkerCell is a free and open-source project under the Berkeley Software Distribution license. Downloads, documentation, and tutorials are available at www.tinkercell.com.Comment: 23 pages, 20 figure

Influence of steel properties on the ductility of doweled timber connections

In the seismic design of structures according to the dissipative structural behaviour, the connection ductility is crucial in order to ensure the desired level of energy dissipation of the overall structure. Therefore, in case of ductile zones composed of dowel-type fasteners arranged in series, it is important to ensure that all the fasteners can fully develop their energy dissipation capacity by plastic deformations. However, when different types of connections made of two symmetrical and serially arranged assemblies of dowel-type fasteners are tested, it often appears that only few fasteners fully work in the plastic region while most of the remaining ones exhibit very low yielding. Looking at the causes of this dysfunction, a possible explanation is due to the fact that the rules for the seismic design of dissipative zones in timber structures given in international codes and used in common practice often make reference only to the steel quality of the dowel-type fasteners specifying a minimum tensile strength or sometime, like is the case of the current version of Eurocode 8, only to maximum values of the dowel-type fastener diameter and of the thickness of the connected timber or wood-based members. Also, the research conducted so far about the ductile behaviour of serially arranged connections was not focused on the post-elastic properties of steel. However, for the seismic design of ductile zones of other materials, such as for example is the case of reinforced concrete walls, post-elastic characteristics of steel are required for the reinforcing bars, in order to achieve the desired dissipative behaviour. Inspired by this fact, timber connections composed of serially arranged dowels made of steel grades with different hardening ratio and elongation at maximum tensile stress were fabricated and tested. The purpose of this work is to understand if the use of steel with significant post-elastic properties may help to solve the problem of limited yielding in serially arranged dowel-type connections. The tested specimens were composed of two symmetrical timber members made of Glulam and LVL connected to two 6 mm thick slotted-in steel plates by means of 9 steel dowels with a diameter of 6.0 mm, which were subjected to monotonic and cyclic tests carried out by implementing dowels made of steel with favourable post-elastic properties. The results showed that the simultaneous yielding of two serially arranged dowelled assemblies is possible, although not fully. Moreover, assuming as reference the steel grade with the lowest post-elastic properties, the connection ductility and strength measured through monotonic and cyclic tests increased by about 30% for the steel grades with the highest hardening ratio and elongation at maximum tensile stress, whereas the displacement at maximum strength was about five times higher. In addition, it was found that confinement of the timber members and shaping of holes were crucial in order to avoid undesired and premature brittle failures and to increase the connection strength and ductility. The results obtained may be useful in order to bring a reassessment of the code requirements regarding the steel properties of ductile connections as well as of certain principles of dimensioning and detailing