Безопасность новых режимов профилактического лечения туберкулеза и приверженность к их соблюдению по данным Республики Казахстан

The objective: to assess the safety and compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis.Subjects and Methods. The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high risk of developing active tuberculosis received preventive tuberculosis treatment with new regimens: 71 patients were treated with isoniazid and rifampicin for 3 months (3 HR), 55 - with isoniazid and rifapentine for 1 month (1 HR), 56 - with levofloxacin for 6 months (6 Lfx).Results. During treatment with regimens 3 HR, 1 HP, 6 Lfx, no adverse events of severity degree 3-4 developed , while adverse events of severity degree 1-2 were rare and relieved. The patient-oriented approach to the organization of preventive chemotherapy made it possible to achieve high treatment completion rates: in the group receiving 3 HR, it was 97.2% of cases, in the group receiving 1 HP - 96.4%, and in the group receiving 6 Lfx - 82.2%.Цель исследования: оценка безопасности и приверженности к соблюдению новых режимов профилактического лечения лекарственно чувствительного и лекарственно устойчивого туберкулеза.Материалы и методы. Исследование выполнено в г. Алматы Республики Казахстан; новые режимы профилактического лечения туберкулеза получили 182 пациента из групп высокого риска развития активного туберкулеза: 71 – изониазид и рифампицин в течение 3 месяцев (3 HR), 55 – изониазид и рифапентин 1 месяц (1 НР), 56 – левофлоксацин 6 месяцев (6 Lfx).Результаты. При приеме режимов 3 HR, 1 HP, 6 Lfx нежелательных явлений 3-4 степени тяжести не наблюдалось, нежелательные явления 1-2 степени токсичности встречались редко и были купированы. Пациентоориентированный подход организации превентивной химиотерапии позволил достигнуть высоких показателей завершения лечения: в группе, получавшей 3 HR, в 97,2% случаев, 1 HP – в 96,4% и 6 Lfx – в 82,2%

INCREASING THE VILLAGE OF THE MOBILE CONTROL STATION COMMUNICATION SYSTEM IN EMERGENCIES

The article describes the topical problems of ensuring the viability of communication systems of mobile control center in extreme and crisis situation and gives recommendation on their main solutions

Converging risk factors but no association between HIV infection and multidrug-resistant tuberculosis in Kazakhstan

S E T T I N G : Kazakhstan is a country with a low HIV/ AIDS (human immunodeficiency virus/acquired immunedeficiency syndrome) burden, but a high prevalence of multidrug-resistant tuberculosis (MDR-TB). M E T H O D S We showed increasing HIV prevalence among TB patients in Kazakhstan. HIV was not an independent risk factor for MDR-TB, but risk factors were largely overlapping and we did identify subgroups at particular risk of HIV-MDR-TB co-infection, notably drug users. Enhanced efforts are necessary to provide care to these socially vulnerable populations