505 research outputs found
How local crustal thermal properties influence the amount of denudation derived from low-temperature thermochronometry: Reply
No abstract available
D-meson decay constants and a check of factorization in non-leptonic B-decays
We compute the vector meson decay constants fD*, fDs* from the simulation of
twisted mass QCD on the lattice with Nf = 2 dynamical quarks. When combining
their values with the pseudoscalar D(s)-meson decay constants, we were able (i)
to show that the heavy quark spin symmetry breaking effects with the charm
quark are large, fDs*/fDs = 1.26(3), and (ii) to check the factorization
approximation in a few specific B-meson non-leptonic decay modes. Besides our
main results, fD* = 278 \pm 13 \pm 10 MeV, and fDs* = 311 \pm 9 MeV, other
phenomenologically interesting results of this paper are: fDs*/fD* = 1.16 \pm
0.02 \pm 0.06, fDs*/fD = 1.46 \pm 0.05 \pm 0.06, and fDs/fD* = 0.89 \pm 0.02
\pm 0.03. Finally, we correct the value for B(B0 \rightarrow D+ pi-) quoted by
PDG, and find B(B0 \rightarrow D+ pi-) = (7.8 \pm 1.4) \times 10-7.
Alternatively, by using the ratios discussed in this paper, we obtain B(B0
\rightarrow D+ pi-) = (8.3 \pm 1.0 \pm 0.8)\times10-7.Comment: 16 pages, 4 eps figure
The photon PDF from high-mass Drell Yan data at the LHC
Achieving the highest precision for theoretical predictions at the LHC requires the calculation of hard-scattering cross-sections that include perturbative QCD corrections up to (N)NNLO and electroweak (EW) corrections up to NLO. Parton distribution functions (PDFs) need to be provided with matching accuracy, which in the case of QED effects involves introducing the photon parton distribution of the proton, . In this work a determination of the photon PDF from fits to recent ATLAS measurements of high-mass Drell-Yan dilepton production at TeV is presented. This analysis is based on the xFitter framework, and has required improvements both in the APFEL program, to account for NLO QED effects, and in the aMCfast interface to account for the photon-initiated contributions in the EW calculations within MadGraph5_aMC@NLO. The results are compared with other recent QED fits and determinations of the photon PDF, consistent results are found
Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer
PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreased
survival, increased metastasis and invasion. The pathways are heavily interconnected and act on a
variety of common efectors that can lead to the development of resistance to drug inhibitors. Most
current treatments exhibit issues with toxicity and resistance. We investigated the novel multikinase
PIM/PI3K/mTOR inhibitor, AUM302, versus a combination of the PIM inhibitor, AZD-1208, and the
PI3K/mTOR inhibitor BEZ235 (Dactolisib) to determine their impact on mRNA and phosphoprotein
expression, as well as their functional efcacy. We have determined that around 20% of prostate
cancer patients overexpress the direct targets of these drugs, and this cohort are more likely to have a
high Gleason grade tumour (≥Gleason 8). A co-targeted inhibition approach ofered broader inhibition
of genes and phosphoproteins in the PI3K/mTOR pathway, when compared to single kinase inhibition.
The preclinical inhibitor AUM302, used at a lower dose, elicited a comparable or superior functional
outcome compared with combined AZD-1208 +BEZ235, which have been investigated in clinical trials,
and could help to reduce treatment toxicity in future trials. We believe that a co-targeting approach is
a viable therapeutic strategy that should be developed further in pre-clinical studies
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