1,777 research outputs found
Stress relaxation in F-actin solutions by severing
Networks of filamentous actin (F-actin) are important for the mechanics of
most animal cells. These cytoskeletal networks are highly dynamic, with a
variety of actin-associated proteins that control cross-linking, polymerization
and force generation in the cytoskeleton. Inspired by recent rheological
experiments on reconstituted solutions of dynamic actin filaments, we report a
theoretical model that describes stress relaxation behavior of these solutions
in the presence of severing proteins. We show that depending on the kinetic
rates of assembly, disassembly, and severing, one can observe both
length-dependent and length-independent relaxation behavior
Indicators of implicit and explicit social anxiety influence threat-related interpretive bias as a function of working memory capacity
Interpretive biases play a crucial role in anxiety disorders. The aim of the current study was to examine factors that determine the relative strength of threat-related interpretive biases that are characteristic of individuals high in social anxiety. Different (dual process) models argue that both implicit and explicit processes determine information processing biases and behavior, and that their impact is moderated by the availability of executive resources such as working memory capacity (WMC). Based on these models, we expected indicators of implicit social anxiety to predict threat-related interpretive bias in individuals low, but not high in WMC. Indicators of explicit social anxiety should predict threat-related interpretive bias in individuals high, but not low in WMC. As expected, WMC moderated the impact of implicit social anxiety on threat-related interpretive bias, although the simple slope for individuals low in WMC was not statistically significant. The hypotheses regarding explicit social anxiety (with fear of negative evaluation used as an indicator) were fully supported. The clinical implications of these findings are discussed
The mechanical response of semiflexible networks to localized perturbations
Previous research on semiflexible polymers including cytoskeletal networks in
cells has suggested the existence of distinct regimes of elastic response, in
which the strain field is either uniform (affine) or non-uniform (non-affine)
under external stress. Associated with these regimes, it has been further
suggested that a new fundamental length scale emerges, which characterizes the
scale for the crossover from non-affine to affine deformations. Here, we extend
these studies by probing the response to localized forces and force dipoles. We
show that the previously identified nonaffinity length [D.A. Head et al. PRE
68, 061907 (2003).] controls the mesoscopic response to point forces and the
crossover to continuum elastic behavior at large distances.Comment: 16 pages, 18 figures; substantial changes to text and figures to
clarify the crossover to continuum elasticity and the role of finite-size
effect
Non-equilibrium microtubule fluctuations in a model cytoskeleton
Biological activity gives rise to non-equilibrium fluctuations in the
cytoplasm of cells; however, there are few methods to directly measure these
fluctuations. Using a reconstituted actin cytoskeleton, we show that the
bending dynamics of embedded microtubules can be used to probe local stress
fluctuations. We add myosin motors that drive the network out of equilibrium,
resulting in an increased amplitude and modified time-dependence of microtubule
bending fluctuations. We show that this behavior results from step-like forces
on the order of 10 pN driven by collective motor dynamics
Sex-Related Differences in the Association of Fundamental Movement Skills and Health and Behavioral Outcomes in Children
This study aimed to assess whether sex moderates the association of fundamental movement skills (FMS) and health and behavioral outcomes. In 170 children (10.6 ± 0.3 years; 98 girls), path-analysis was used to assess the associations of FMS (Get Skilled, Get Active) with perceived sports competence (Children and Youth - Physical Self-Perception Profile), time spent in vigorous-intensity physical activity (VPA), sedentary time and body mass index (BMI) z-score. For boys, object control skill competence had a direct association with perceived sports competence (β = 0.39; 95% CI: 0.21 to 0.57) and an indirect association with sedentary time, through perceived sports competence (β = -0.19; 95% CI: -0.09 to -0.32). No significant association was observed between FMS and perceived sports competence for girls, although locomotor skills were found to predict VPA (β = 0.18; 95% CI: 0.08 to 0.27). Perceived sports competence was associated with sedentary time, with this stronger for boys (β = -0.48; 95% CI: -0.64 to -0.31), than girls (β = -0.29; 95% CI: -0.39 to -0.19). The study supports a holistic approach to health-related interventions and highlights a key association of perceived sports competence and the time children spend sedentary
One-Bead Microrheology with Rotating Particles
We lay the theoretical basis for one-bead microrheology with rotating
particles, i.e, a method where colloids are used to probe the mechanical
properties of viscoelastic media. Based on a two-fluid model, we calculate the
compliance and discuss it for two cases. We first assume that the elastic and
fluid component exhibit both stick boundary conditions at the particle surface.
Then, the compliance fulfills a generalized Stokes law with a complex shear
modulus whose validity is only limited by inertial effects, in contrast to
translational motion. Secondly, we find that the validity of the Stokes regime
is reduced when the elastic network is not coupled to the particleComment: 7 pages, 5 figures, submitted to Europhys. Let
Elastic Scattering Phenomenology
We argue that, in many situations, fits to elastic scattering data that were historically, and frequently still are, considered “good”, are not justifiably so describable. Information about the dynamics of nucleon-nucleus and nucleus-nucleus scattering is lost when elastic scattering phenomenology is insufficiently ambitious. It is argued that in many situations, an alternative approach is appropriate for the phenomenology of nuclear elastic scattering of nucleons and other light nuclei. The approach affords an appropriate means of evaluating folding models, one that fully exploits available empirical data. It is particularly applicable for nucleons and other light ions
Theoretical Study of Fluid Membranes of Spherical Topology with Internal Degrees of Freedom
A theoretical study of vesicles of topological genus zero is presented. The
bilayer membranes forming the vesicles have various degrees of intrinsic
(tangent-plane) orientational order, ranging from smectic to hexatic,
frustrated by curvature and topology. The field-theoretical model for these
`-atic' surfaces has been studied before in the low temperature (mean-field)
limit. Work presented here includes the effects of thermal fluctuations. Using
the lowest Landau level approximation, the coupling between order and shape is
cast in a simple form, facilitating insights into the behaviour of vesicles.
The order parameter contains vortices, whose effective interaction potential is
found, and renormalized by membrane fluctuations. The shape of the phase space
has a counter-intuitive influence on this potential. A criterion is established
whereby a vesicle of finite rigidity may be burst by its own in-plane order,
and an analogy is drawn with flux exclusion from a type-I superconductor.Comment: 34 pages + 4 Postscript figures. Uses RevTe
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