Free amino acids of the blood and some organs in hypokinesia

The metabolic fund of amino acids of the blood and tissues of rats under hypokinesia was investigated. The content of free amino acids was determined for the liver, kidney, brain, and the skeletal and cardiac muscles after established periods of hypokinesia. It was found that the total content of free amino acids in the experimental animals was, on the average 19 percent lower than in the controls. The results of the quantity of individual compounds indicate that the level of some were reduced while others were increased. It was also found that there was an unequal content of individual amino acids in the different tissues

Trends in the formation of the ovarian follicular reserve

This review describes folliculogenesis from the formation of a primordial follicle around the oocyte during the diplotene stage of prophase of meiosis I to that of a preovulatory follicle, maturation of an oocyte, and transformation of its chromosomal nucleolus complex into the karyosphere. It briefly highlights literature disagreements on the terminology of ovarian follicular reserve and folliculogenesis. The possibilities of evaluating the ovarian follicular system are given

Эмболизация маточных артерий в терапии послеродовых гипотонических кровотечений

Postpartum hemorrhage is a serious obstetric complication due to the threat to the life and health of a woman. One of the common causes of bleeding in the postpartum period is uterine hypotension. If conservative methods of treating hypotonic bleeding are ineffective, hemostatic compression sutures are applied to the body of the uterus, ligation/clipping of the main vessels of the uterus and (or) ligation of the internal iliac arteries. If available, endovascular uterine artery embolization (UAE) is performed. The review is devoted to the efficacy and safety of UAE in pregnant women with postpartum hypotonic bleeding, as well as to the long-term results of follow-up. Послеродовые кровотечения являются серьезным акушерским осложнением вследствие опасности для жизни и здоровья женщины. Одной из частых причин кровотечения в послеродовом периоде является гипотония матки. При неэффективности консервативных методов лечения гипотонического кровотечения проводится наложение гемостатических компрессионных швов на тело матки, перевязка/клипирование магистральных сосудов матки и(или) перевязка внутренних подвздошных артерий. При наличии возможности выполняется эндоваскулярная эмболизация маточных артерий (ЭМА). Обзор посвящен эффективности и безопасности ЭМА у родильниц с послеродовым гипотоническим кровотечением, а также отдаленным результатам наблюдения таких пациенток

Опыт применения вено-венозной экстракорпоральной мембранной оксигенации у беременной с тяжелым острым респираторным дистресс-синдромом, вызванным вирусом SARS-CoV-2

 Pregnant women occupy a special place in the incidence structure of the new coronavirus infection COVID -19. Taking into account the likelihood of a more severe course of acute respiratory syndrome (ARDS) in this group, it is worth remembering the possibility of timely use of veno-venous extracorporeal membrane oxygenation (IV ECMO) in order to correct life-threatening hypoxia. At the Lapino Clinical Hospital, a cesarean section was successfully performed in a 37-year-old female patient at 20–21 weeks of gestation against the background of IV ECMO with further decannulation  and discharge from the hospital.  Особое место в структуре заболеваемости новой коронавирусной инфекцией COVID-19 занимают беременные. Принимая во внимание вероятность более тяжелого течения острого респираторного синдрома  (ОРДС) у данной группы, стоит помнить о возможности своевременного  применения вено-венозной экстракорпоральной мембранной оксигенации  (ВВ ЭКМО) с целью коррекции жизнеугрожающей гипоксии. В клиническом госпитале «Лапино» было успешно выполнено кесарево сечение у пациентки 37 лет на 20–21-й неделе гестации на фоне ВВ ЭКМО с дальнейшей деканюляцией и выпиской из стационара.

COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy

During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1 в, interleukin-6, interferon-Y, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women