Prostate Cancer Microparticles as a Next Generation Screening Tool for Prostate Cancer

Currently available screening tests for prostate cancer (PCa) are neither very sensitive nor specific. Microparticles (MP) are submicron tumor cell fragments released by PCa cells into the circulation and offer a possible means of sampling the tumor. We evaluated the utility of a MP blood test using nanoscale flow cytometry to distinguish patients with PCa from patients with benign prostatic hyperplasia (BPH). We used monoclonal antibodies against prostate specific membrane antigen, gastrin releasing peptide receptor and ghrelin peptide ligand. We found higher but statistically insignificant, PSMA and Ghrelin dual +ve MP counts in the BPH group. Our results show that although MP can be enumerated, better more exclusive surface antigens and different antibodies, are required to test the utility of MP for this to be used as a Next Generation Screening Tool for PCa. In addition, comparison with a more suitable control group would improve accuracy of the experimental test

Chondroid tenosynovial giant cell tumour : a rarity in the temporomandibular joint

Tenosynovial giant cell tumours of the temporomandibular joint (TMJ) are extremely rare, particularly the subset of chondroid tumours. They can be broadly divided into localised and diffuse types, of which we know of only 116 reported cases in the TMJ. Rarer still are the subset of chondroid tenosynovial giant cell tumours, of which we know of only 30 cases that have affected the TMJ. We present a case that involved the TMJ, and include a discussion of its management

A Novel Approach for Creating Consistent Trust and Cooperation (CTC) among Mobile Nodes of Ad Hoc Network

The final publication is available at www.springerlink.comThis paper provides a critical analysis of the recent research wok and its impact on the overall performance of a mobile Ad hoc network. In this paper, we clarify some of the misconceptions in the understating of selfishness and miss-behavior of nodes. Moreover, we propose a mathematical model that based on the time division technique to minimize the node misbehavior by avoiding unnecessary elimination of bad nodes. Our proposed approach not only improves the resource sharing but also creates a consistent trust and cooperation (CTC) environment among the mobile nodes. We believe, that the proposed mathematical model not only points out the weaknesses of the recent research work but also approximates the optimal values of the critical parameters such as throughput, transmission over head, channel capacity etc. The simulation results demonstrate the success of the proposed approach that significantly minimizes the malicious nodes and consequently maximizes the overall throughput of the Ad Hoc network than the other well known schemes.http://link.springer.com/chapter/10.1007/978-1-4020-8737-0_9

Ceramic-reinforced HEA matrix composites exhibiting an excellent combination of mechanical properties

CoCrFeNi is a well-studied face centered cubic (fcc) high entropy alloy (HEA) that exhibits excellent ductility but only limited strength. The present study focusses on improving the strength-ductility balance of this HEA by addition of varying amounts of SiC using an arc melting route. Chromium present in the base HEA is found to result in decomposition of SiC during melting. Consequently, interaction of free carbon with chromium results in the in-situ formation of chromium carbide, while free silicon remains in solution in the base HEA and/or interacts with the constituent elements of the base HEA to form silicides. The changes in microstructural phases with increasing amount of SiC are found to follow the sequence: fcc → fcc + eutectic → fcc + chromium carbide platelets → fcc + chromium carbide platelets + silicides → fcc + chromium carbide platelets + silicides + graphite globules/flakes. In comparison to both conventional and high entropy alloys, the resulting composites were found to exhibit a very wide range of mechanical properties (yield strength from 277 MPa with more than 60% elongation to 2522 MPa with 6% elongation). Some of the developed high entropy composites showed an outstanding combination of mechanical properties (yield strength 1200 MPa with 37% elongation) and occupied previously unattainable regions in a yield strength versus elongation map. In addition to their significant elongation, the hardness and yield strength of the HEA composites are found to lie in the same range as those of bulk metallic glasses. It is therefore believed that development of high entropy composites can help in obtaining outstanding combinations of mechanical properties for advanced structural applications.Financial support from the Higher Education Commission of Pakistan (HEC NRPU 6019) is acknowledged. FEDER National funds FCT under the project CEMMPRE, ref. “UIDB/00285/2020” is also acknowledged.info:eu-repo/semantics/publishedVersio

Secondary Fahr’s Disease: A Consequence of Post-Thyroidectomy Hypoparathyroidism

Objective: The objective of this case report is to emphasize the importance of considering uncommon conditions like Fahr’s disease in the differential diagnosis of seizures and cognitive impairment, especially in patients with a history of thyroidectomy. Material and Methods: A 56-year-old woman who had undergone subtotal thyroidectomy 25 years previously presented with movement disorder and cognitive impairment secondary to hypoparathyroidism. A CT scan of the brain showed pathognomonic bilateral calcification in the basal ganglia, thalamus and cerebellar nuclei. Result: The patient was diagnosed with Fahr’s disease caused by post-thyroidectomy hypoparathyroidism and successfully managed with oral calcium, carbidopa/levodopa and haloperidol. Conclusion: We recommend the routine use of CT scanning in the long-term follow-up of post-thyroidectomy patients

Impedance Control Network Resonant dc-dc Converter for Wide-Range High-Efficiency Operation

This paper introduces a new resonant converter architecture that utilizes multiple inverters and a lossless impedance control network (ICN) to maintain zero voltage switching (ZVS) and near zero current switching (ZCS) across wide operating ranges. Hence, the ICN converter is able to operate at fixed frequency and maintain high efficiency across wide ranges in input and output voltages and output power. The ICN converter architecture enables increase in switching frequency (hence reducing size and mass) while achieving very high efficiency. Three prototype 200 W, 500 kHz ICN resonant converters, one with low-Q, one with medium-Q and one with high-Q resonant tanks, designed to operate over an input voltage range of 25 V to 40 V and an output voltage range of 250 V to 400 V are built and tested. The low-Q prototype ICN converter achieves a peak efficiency of 97.1%, maintains greater than 96.4% full power efficiency at 250 V output voltage across the nearly 2:1 input voltage range, and maintains full power efficiency above 95% across its full input and output voltage range. It also maintains efficiency above 94.6% over a 10:1 output power range across its full input and output voltage range owing to the use of burst-mode control.National Science Foundation (U.S.) (Award 1307699

High-grade urothelial carcinoma with squamous differentiation metastasizing to the tongue.

Tumors metastasizing to the head and neck region are uncommon. Metastasis of urothelial carcinoma to the maxillofacial region is exceedingly rare and mostly involves the jaw. We present a case of urothelial carcinoma metastasizing to the tongue. Immunohistochemistry in conjunction with fluorescent in situ hybridization was used to confirm the relation between the primary and metastatic lesions, making it the first such reported case employing the UroVysion (Catalogue number 02 J27-025, Abbott Molecular Inc., Des Plaines, IL, USA) fluorescent in situ hybridization probe in a metastatic lesion in the head and neck region

Surgical ligation of scrotal varicocele for male factor infertility is a valid option of treatment

Objective: To evaluate the role of surgical ligation of scrotal varicocele for treatment of male factor infertility. Methods: We studied 60 patients who presented with infertility and were also found to have scrotal varicocele. Patients with other probable causes contributing to infertility were excluded. Diagnosis was made by clinical examination and scrotal ultrasonography. All the patients underwent either laparoscopic varicocelectomy or open retroperitoneal high ligation of the testicular veins. Operative time and hospital stay was recorded. All patients were evaluated for postoperative improvement of semen parameters and development of any postoperative complication. The results were analyzed by commercially available software. Results: During the study period 5 patients were lost to follow up and were excluded. The rest of patients (n=55) were young, with age ranging from 20-35 years (Mean age 27.8 years, SD +/- 4.38). All patients had unilateral left sided varicocele; two patients (3.6%) had grade I varicocele, 21 patients (38.2%) had grade II varicocele and 32 patients (58.2%) had grade III varicocele. Statistically significant improvement in sperm density (p value \u3c 0.05), sperm activity (p value \u3c 0.05) and sperm morphology (p value \u3c 0.05) was observed after the surgical ligation. The mean operative time was 54.88 minutes (SD + 13). The mean hospital stay in laparoscopic procedure was 33.4 (SD + 15.3). Minor complications were noted in 13 patients and included superficial wound infection in 3 patients, 6 patients exhibited testicular pain and persistence of varicocele in 4 patients. Conclusion: Surgical ligation of scrotal varicocele is asafe and effective mode of treatment of male factor infertility in selected population